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- Antibody Data
- Antigen structure
- References [144]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10785-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10785-1-AP, RRID:AB_2281164
- Product name
- LDLR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LDLR antibody (Cat. #10785-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer's Disease.
Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway.
Heteroduplex oligonucleotide technology boosts gene knockdown in cardiac and skeletal muscles.
Low-density lipoprotein receptor interacts with clusterin to regulate A1/A2 astrocyte polarization and ameliorate hemorrhagic brain injury.
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus.
Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation.
In vivo epigenome editing reduces circulating lipids and attenuates atherosclerosis in mice.
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery.
Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression.
NPC1 as a novel therapeutic target for induction of pyroptosis in cancers.
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
A High-Fat Diet Damages the Blood-Testis Barrier Through the PCSK9-LOX1 Positive Feedback Loop in Sertoli Cells.
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Impaired ApoB secretion triggers enhanced secretion of ApoE to maintain triglyceride homeostasis in hepatoma cells.
Combination Therapy of Half-Dose Resmetirom and Metformin Attenuates Metabolic Dysfunction-Associated Steatohepatitis Through Improving Cholesterol Metabolism and Inflammation.
Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis.
SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.
A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.
Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis.
Natural Product Bruceine A from Brucea javanica (L.) Merr. as a Potential LDLR Inhibitor That Facilitates Antiviral Effect.
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Systemic and Retinal Protective Effects of Butyrate in Early Type 2 Diabetes via Gut Microbiota-Lipid Metabolism Interaction.
Low-density Lipoprotein Receptor is an important host factor in flaviviral entry and replication in neurons.
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor.
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
Syncytin-1 deficiency impairs placental nutrient transport via PI3K/Akt/mTOR signaling.
Hypercholesterolemia drives microglial dysfunction and weakens response to amyloid plaques.
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation.
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Dapagliflozin modulates hepatic lipid metabolism through the proprotein convertase subtilisin/kexin type 9/low density lipoprotein receptor pathway.
ADAM9 drives the immunosuppressive microenvironment by cholesterol biosynthesis-mediated activation of IL6-STAT3 signaling for lung tumor progression.
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis.
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.
Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens.
A gut-derived hormone regulates cholesterol metabolism.
Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia.
Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism.
Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry.
The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.
Efficient prime editing in mouse brain, liver and heart with dual AAVs.
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Porcine low-density lipoprotein receptor plays an important role in classical swine fever virus infection.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia.
Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.
Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
Commercial lipoprotein-deficient sera differ in iron content.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice.
Regulation of low-density lipoprotein on lipid metabolism in macrophages of large yellow croaker (Larimichthys crocea).
Maternal high-calorie diet feeding programs hepatic cholesterol metabolism and Abca1 promoter methylation in the early life of offspring.
Chrysin 7-O-β-d-glucopyranoside increases hepatic low-density lipoprotein receptor expression through AMP-activated protein kinase activation.
In situ isolation of nuclei or nuclear proteins from adherent cells: a simple, effective method with less cytoplasmic contamination.
Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.
Engineered Red Blood Cell Membrane-Coating Salidroside/Indocyanine Green Nanovesicles for High-Efficiency Hypoxic Targeting Phototherapy of Triple-Negative Breast Cancer.
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency.
Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial.
Highland barley Monascus purpureus Went extract ameliorates high-fat, high-fructose, high-cholesterol diet induced nonalcoholic fatty liver disease by regulating lipid metabolism in golden hamsters.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease.
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.
LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis.
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Fused-ring α-pyrones from intramolecular C-H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation.
The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes.
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells.
Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses.
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling.
New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice.
Identification of a novel mechanism for meso-tetra (4-carboxyphenyl) porphyrin (TCPP) uptake in cancer cells.
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice.
A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system.
Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages.
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
MicroRNA-148a regulates low-density lipoprotein metabolism by repressing the (pro)renin receptor.
A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake.
Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.
Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes.
Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia.
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages.
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Polydatin Improves Glucose and Lipid Metabolisms in Insulin-Resistant HepG2 Cells through the AMPK Pathway.
Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain.
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
A Novel Role of Id1 in Regulating Oscillatory Shear Stress-Mediated Lipid Uptake in Endothelial Cells.
In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing.
Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop.
Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.
Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.
Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection.
Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism.
Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats.
Exogenous administration of chronic corticosterone affects hepatic cholesterol metabolism in broiler chickens showing long or short tonic immobility.
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice.
The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine.
Cholesterol deregulation induced by chronic corticosterone (CORT) stress in pectoralis major of broiler chickens.
Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice.
TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.
Yu Y, Ma Z, Li T, Xiao W, Li Z
Journal of extracellular vesicles 2026 Mar;15(3):e70248
Journal of extracellular vesicles 2026 Mar;15(3):e70248
Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway.
Wang T, Zhang L, Wang Y, Xing J, Xu L, Hu X, Su W, Zheng R
Metabolites 2026 Mar 31;16(4)
Metabolites 2026 Mar 31;16(4)
Heteroduplex oligonucleotide technology boosts gene knockdown in cardiac and skeletal muscles.
Matsuda-Kawabata S, Nagata T, Yanagidaira M, Ihara K, Ohyagi M, Kaburagi H, Yoshida-Tanaka K, Sasaki A, Abe A, Ebihara S, Hasegawa J, Toide N, Ohara M, Naito M, Miyata K, Toh K, Sakaue F, Yokota T
Nucleic acids research 2026 Jan 22;54(3)
Nucleic acids research 2026 Jan 22;54(3)
Low-density lipoprotein receptor interacts with clusterin to regulate A1/A2 astrocyte polarization and ameliorate hemorrhagic brain injury.
Yin H, Li X Jr, Yang J, Lu J, Xu Z, Bai L, Liu J, Sun C, Li H
Experimental neurology 2026 Feb;396:115539
Experimental neurology 2026 Feb;396:115539
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
Du J, Jin L, Wang S, Hu X, Yu J, Yu J, Huo Q, Wu N, Liu X, Yang Y, Zhang Y, Huang S, Zhou J, Zheng SG, Zheng C, Zhu X
Nucleic acids research 2026 Feb 24;54(5)
Nucleic acids research 2026 Feb 24;54(5)
The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus.
Shiota T, Zhao Y, Shiota I, Duyvesteyn HME, Yamaoka M, Das A, Kapustina M, Shah P, Muramatsu M, Wang X, Fry EE, Stuart DI, Lemon SM
Proceedings of the National Academy of Sciences of the United States of America 2026 Apr 7;123(14):e2534261123
Proceedings of the National Academy of Sciences of the United States of America 2026 Apr 7;123(14):e2534261123
Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation.
Feng B, Shi Y, Xu J, Hu M, Liang S, Li Y, Gan W
ACS chemical biology 2026 Apr 17;21(4):801-811
ACS chemical biology 2026 Apr 17;21(4):801-811
In vivo epigenome editing reduces circulating lipids and attenuates atherosclerosis in mice.
Wang W, Zhang Y, Chen L, Lu Y, He Y, Cheng H, Tang T, Li X, Zhang J, Liu Y, Wang Y, Kong Y, Yuan H
Journal of genetics and genomics = Yi chuan xue bao 2026 Apr 13;
Journal of genetics and genomics = Yi chuan xue bao 2026 Apr 13;
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Zhao Y, Liu M, Zang X, Li J, Zhang G, Du P, Zhang T, Sun X, Li C, Liu L
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X, Ni X, Chen Y, Wang J, Liang X, Xie Z, Li J, Banach M, Pelisek J, Huo Y, Hu Y, Evans PC, Wang L, Tian XY, Xiao J, Shang Y, Zheng Y, Xian X, Weng J, Xu S
Theranostics 2025;15(10):4325-4344
Theranostics 2025;15(10):4325-4344
A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery.
Jiao P, Yang N, Jia Q, Fan B, Feng K, Yu J, Zhao S
Frontiers in molecular biosciences 2025;12:1552085
Frontiers in molecular biosciences 2025;12:1552085
Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression.
Cao M, Li M, Li X, Li Y, Chen Y, Drekolia MK, Cheng X, Lagos FD, Bibli SI, Hu J
Redox biology 2025 Sep;85:103730
Redox biology 2025 Sep;85:103730
NPC1 as a novel therapeutic target for induction of pyroptosis in cancers.
Zhang C, Wang Q, Su P, Qian J, Guo Q, Wu W, Duan R, Zhang Y, Zu Y, Zhong L, Xiao L, Yi Q
Biomarker research 2025 Sep 26;13(1):115
Biomarker research 2025 Sep 26;13(1):115
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Sun T, Wu Y, Liu G, Xue Z, Yu M, Mao B, Han M, Liang X, Ling L, You N, Ji L, Liu H, Xu C, Qin Z, Zhao P, Wang D
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
A High-Fat Diet Damages the Blood-Testis Barrier Through the PCSK9-LOX1 Positive Feedback Loop in Sertoli Cells.
Zhang G, Wang Z, He M, Kong L, Yushanjiang S, Jin L, Zhao R, Ma Z, Pan Y, Hu Y, Nie L, Yuan D
Reproductive sciences (Thousand Oaks, Calif.) 2025 Nov;32(11):3587-3598
Reproductive sciences (Thousand Oaks, Calif.) 2025 Nov;32(11):3587-3598
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
Hong L, Xia S, Chen N, Wang Z, Li Z
Nutrition & metabolism 2025 Nov 24;22(1):159
Nutrition & metabolism 2025 Nov 24;22(1):159
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
Impaired ApoB secretion triggers enhanced secretion of ApoE to maintain triglyceride homeostasis in hepatoma cells.
Shinozaki K, Honda T, Yamaji K, Nishijima E, Ichi I, Yamane D
Journal of lipid research 2025 May;66(5):100795
Journal of lipid research 2025 May;66(5):100795
Combination Therapy of Half-Dose Resmetirom and Metformin Attenuates Metabolic Dysfunction-Associated Steatohepatitis Through Improving Cholesterol Metabolism and Inflammation.
Liu W, Yao F, Wang J, Shao N, Cao X, Dong Z, Zhang B, Sun X
Biomedicines 2025 May 27;13(6)
Biomedicines 2025 May 27;13(6)
Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis.
Xu L, Xu J, Shi W, Zhang S, Guo T, Zou S
Lipids in health and disease 2025 May 10;24(1):171
Lipids in health and disease 2025 May 10;24(1):171
SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
Shi L, Chen H, Zhang Y, An D, Qin M, Yu W, Wen B, He D, Hao H, Xiong J
The EMBO journal 2025 Mar;44(5):1442-1463
The EMBO journal 2025 Mar;44(5):1442-1463
Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.
Pelucchi S, Da Dalt L, De Cesare G, Stringhi R, D'Andrea L, La Greca F, Cambria C, Vandermeulen L, Zianni E, Musardo S, Roda S, Bonacina F, Nasini S, Lupo MG, Ferri N, Comai S, Gardoni F, Antonucci F, Scheggia D, Di Luca M, Norata GD, Marcello E
Pharmacological research 2025 Mar;213:107652
Pharmacological research 2025 Mar;213:107652
A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.
Roussis IM, Pearton DJ, Niazi U, Tsaknakis G, Papadopoulos GL, Cook R, Saqi M, Ragoussis J, Strouboulis J
PLoS genetics 2025 Mar;21(3):e1011617
PLoS genetics 2025 Mar;21(3):e1011617
Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis.
Shan H, Fan S, Li Q, Liang R, Chen Z, Wang S, Wang X, Li Y, Chen S, Yu K, Fei T
Genome biology 2025 Mar 17;26(1):59
Genome biology 2025 Mar 17;26(1):59
Natural Product Bruceine A from Brucea javanica (L.) Merr. as a Potential LDLR Inhibitor That Facilitates Antiviral Effect.
Zuo K, Liu N, Zhou P, Wei Y, Lin J, Zhu X
ACS omega 2025 Jul 8;10(26):28210-28219
ACS omega 2025 Jul 8;10(26):28210-28219
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Wang Z, Liu J, Mou Y, Zhou X, Liao W, Li Y, Liu Y, Tang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Systemic and Retinal Protective Effects of Butyrate in Early Type 2 Diabetes via Gut Microbiota-Lipid Metabolism Interaction.
Gong H, Zuo H, Wu K, Gao X, Lan Y, Zhao L
Nutrients 2025 Jul 18;17(14)
Nutrients 2025 Jul 18;17(14)
Low-density Lipoprotein Receptor is an important host factor in flaviviral entry and replication in neurons.
Bhaskar M, Satheesan A, Basu A
Biochemical and biophysical research communications 2025 Jan;743:151160
Biochemical and biophysical research communications 2025 Jan;743:151160
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor.
Mei W, Faraj Tabrizi S, Godina C, Lovisa AF, Isaksson K, Jernström H, Tavazoie SF
Cell 2025 Jan 23;188(2):371-389.e28
Cell 2025 Jan 23;188(2):371-389.e28
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, Liu C, Wu H
Nature communications 2025 Jan 2;16(1):333
Nature communications 2025 Jan 2;16(1):333
Syncytin-1 deficiency impairs placental nutrient transport via PI3K/Akt/mTOR signaling.
Chen XL, Gong XX, Xiong ZL, Zhou D, Yang J, Zhang HF, Xue YS, Wang YN, Chen HB
The Journal of nutritional biochemistry 2025 Dec;146:110060
The Journal of nutritional biochemistry 2025 Dec;146:110060
Hypercholesterolemia drives microglial dysfunction and weakens response to amyloid plaques.
Kaye S, Gold A, Lin D, Chen M, Zhu J, Gao J
Experimental neurology 2025 Aug;390:115272
Experimental neurology 2025 Aug;390:115272
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation.
Nagao K, Matsuo M, Hori Y, Namba N, Saito H
The Journal of biological chemistry 2025 Aug;301(8):110457
The Journal of biological chemistry 2025 Aug;301(8):110457
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Li J, Wang M, Qu K, Sun Y, Yin Z, Dong N, Sun X, Xu Y, Chen L, Zhang S, Xian X, Xu S, Ma L, Duan Y, Zhu H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Dapagliflozin modulates hepatic lipid metabolism through the proprotein convertase subtilisin/kexin type 9/low density lipoprotein receptor pathway.
Lu F, Li E, Gao Y, Zhang Y, Kong L, Yang X
Diabetes, obesity & metabolism 2025 Apr;27(4):2096-2109
Diabetes, obesity & metabolism 2025 Apr;27(4):2096-2109
ADAM9 drives the immunosuppressive microenvironment by cholesterol biosynthesis-mediated activation of IL6-STAT3 signaling for lung tumor progression.
Liu JP, Shen KY, Cheng WC, Chang WC, Hsieh CY, Lo CC, Kuo TT, Lin CC, Liu SJ, Huang WC, Sher YP
American journal of cancer research 2024;14(4):1850-1865
American journal of cancer research 2024;14(4):1850-1865
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis.
Zhou X, Nie M, Xin X, Hua T, Zhang J, Shi R, Dong K, Shu W, Yan B, Wang H
Cell death & disease 2024 Sep 6;15(9):655
Cell death & disease 2024 Sep 6;15(9):655
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y
Cell reports 2024 Sep 24;43(9):114691
Cell reports 2024 Sep 24;43(9):114691
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.
Wang WZ, Liu C, Luo JQ, Lei LJ, Chen MH, Zhang YY, Sheng R, Li YN, Wang L, Jiang XH, Xiao TM, Zhang YH, Li SW, Wu YX, Xu Y, Xu YN, Si SY
Acta pharmacologica Sinica 2024 Oct;45(10):2119-2133
Acta pharmacologica Sinica 2024 Oct;45(10):2119-2133
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.
Fu R, Xue W, Liang J, Li X, Zheng J, Wang L, Zhang M, Meng J
Cell death & disease 2024 May 9;15(5):325
Cell death & disease 2024 May 9;15(5):325
Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens.
Wu Y, Zhang M, Meng F, Ren K, Li D, Luo X, Hu Y
Poultry science 2024 Mar;103(3):103435
Poultry science 2024 Mar;103(3):103435
A gut-derived hormone regulates cholesterol metabolism.
Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y
Cell 2024 Mar 28;187(7):1685-1700.e18
Cell 2024 Mar 28;187(7):1685-1700.e18
Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia.
Fang Q, Lu X, Zhu Y, Lv X, Yu F, Ma X, Liu B, Zhang H
Cell reports. Medicine 2024 Jun 18;5(6):101614
Cell reports. Medicine 2024 Jun 18;5(6):101614
Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism.
Feng H, Liu G, Li L, Ren X, Jiang Y, Hou W, Liu R, Liu K, Liu H, Huang H
ACS omega 2024 Jun 11;9(23):24308-24320
ACS omega 2024 Jun 11;9(23):24308-24320
Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
Xian M, Wang Q, Xiao L, Zhong L, Xiong W, Ye L, Su P, Zhang C, Li Y, Orlowski RZ, Zhan F, Ganguly S, Zu Y, Qian J, Yi Q
Nature communications 2024 Jul 9;15(1):5767
Nature communications 2024 Jul 9;15(1):5767
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Tang S, Yao L, Ruan J, Kang J, Cao Y, Nie X, Lan W, Zhu Z, Han W, Liu Y, Tian J, Seale P, Qin L, Ding C
Science translational medicine 2024 Jan 24;16(731):eadf4590
Science translational medicine 2024 Jan 24;16(731):eadf4590
Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry.
Ma Y-X, Chai Y-J, Han Y-Q, Zhao S-B, Yang G-Y, Wang J, Ming S-L, Chu B-B
Journal of virology 2024 Jan 23;98(1):e0166423
Journal of virology 2024 Jan 23;98(1):e0166423
The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.
Maghe C, Trillet K, André-Grégoire G, Kerhervé M, Merlet L, Jacobs KA, Schauer K, Bidère N, Gavard J
Cell reports 2024 Jan 23;43(1):113631
Cell reports 2024 Jan 23;43(1):113631
Efficient prime editing in mouse brain, liver and heart with dual AAVs.
Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR
Nature biotechnology 2024 Feb;42(2):253-264
Nature biotechnology 2024 Feb;42(2):253-264
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Lee YN, Wu YJ, Su CH, Wang BJ, Yang SH, Lee HI, Chou YH, Tien TY, Lin CF, Chan WH, Chung CH, Wang SW, Yeh HI
Redox biology 2024 Dec;78:103427
Redox biology 2024 Dec;78:103427
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Porcine low-density lipoprotein receptor plays an important role in classical swine fever virus infection.
Leveringhaus E, Poljakovic R, Herrmann G, Roman-Sosa G, Becher P, Postel A
Emerging microbes & infections 2024 Dec;13(1):2327385
Emerging microbes & infections 2024 Dec;13(1):2327385
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D
Cell 2024 Aug 8;187(16):4272-4288.e20
Cell 2024 Aug 8;187(16):4272-4288.e20
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Chen M, Wen J, Qiu Y, Gao X, Zhang J, Lin Y, Wu Z, Lin X, Zhu A
Toxins 2024 Aug 24;16(9)
Toxins 2024 Aug 24;16(9)
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia.
Tan L, Kluivers ACM, Cruz-López EO, Broekhuizen M, Chen Z, Neuman RI, Schoenmakers S, Ruijgrok L, van de Velde D, de Winter BCM, van den Bogaerdt AJ, Lu X, Danser AHJ, Verdonk K
Hypertension (Dallas, Tex. : 1979) 2024 Apr;81(4):861-875
Hypertension (Dallas, Tex. : 1979) 2024 Apr;81(4):861-875
Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.
Khalifa A, Guijarro A, Ravera S, Bertola N, Adorni MP, Papotti B, Raffaghello L, Benelli R, Becherini P, Namatalla A, Verzola D, Reverberi D, Monacelli F, Cea M, Pisciotta L, Bernini F, Caffa I, Nencioni A
Nature communications 2023 Oct 31;14(1):6951
Nature communications 2023 Oct 31;14(1):6951
Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
Xu J, Ma H, Shi L, Zhou H, Cheng Y, Tong J, Meng B, Xu X, He K, Ding S, Zhang J, Yue L, Xiang G
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):e443-e467
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):e443-e467
PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.
Yu M, Tang W, Liang W, Xie B, Gao R, Ding P, Gu X, Wang M, Wen S, Sun P
International immunopharmacology 2023 Nov;124(Pt B):110962
International immunopharmacology 2023 Nov;124(Pt B):110962
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Doppler C, Messner B, Mimler T, Schachner B, Rezk M, Ganhör C, Wechselberger C, Müller M, Puh S, Pröll J, Arbeithuber B, Müller T, Zierer A, Bernhard D
Journal of lipid research 2023 Mar;64(3):100338
Journal of lipid research 2023 Mar;64(3):100338
Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.
Abdelwahed KS, Siddique AB, Ebrahim HY, Qusa MH, Mudhish EA, Rad AH, Zerfaoui M, Abd Elmageed ZY, El Sayed KA
Marine drugs 2023 Mar 28;21(4)
Marine drugs 2023 Mar 28;21(4)
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916
iScience 2023 Jun 16;26(6):106916
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
Guo HH, Shen HR, Wang LL, Luo ZG, Zhang JL, Zhang HJ, Gao TL, Han YX, Jiang JD
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114754
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114754
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
Ge Y, Zhang L, Chen W, Sun M, Liu W, Li X
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
Commercial lipoprotein-deficient sera differ in iron content.
Laffin JM, Shao W, Espenshade PJ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Feb;1868(2):159260
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Feb;1868(2):159260
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice.
Li Z, He M, Chen G, Worgall TS, Jiang XC
bioRxiv : the preprint server for biology 2023 Feb 7;
bioRxiv : the preprint server for biology 2023 Feb 7;
Regulation of low-density lipoprotein on lipid metabolism in macrophages of large yellow croaker (Larimichthys crocea).
Hao T, Xu D, Cao X, Chen Q, Chen F, Liu Q, Tang Y, Zhou Y, Li Y, Mai K, Ai Q
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Dec;1868(12):159397
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Dec;1868(12):159397
Maternal high-calorie diet feeding programs hepatic cholesterol metabolism and Abca1 promoter methylation in the early life of offspring.
Zhang L, Zou W, Hu Y, Wu H, Gao Y, Zhang J, Zheng J
The Journal of nutritional biochemistry 2023 Dec;122:109449
The Journal of nutritional biochemistry 2023 Dec;122:109449
Chrysin 7-O-β-d-glucopyranoside increases hepatic low-density lipoprotein receptor expression through AMP-activated protein kinase activation.
Kaname N, Fujimaki T, Horikoshi S, Fujimura K, Kodaka M, Wakamori S, Katsuta R, Ishigami K, Suzuki T, Yamamoto Y, Inoue J
FEBS open bio 2023 Aug;13(8):1447-1458
FEBS open bio 2023 Aug;13(8):1447-1458
In situ isolation of nuclei or nuclear proteins from adherent cells: a simple, effective method with less cytoplasmic contamination.
Qin Y, Zhou Y, Wang K, Gu J, Xiong Z, Zhang W, Chen Y
Biological research 2023 Apr 21;56(1):18
Biological research 2023 Apr 21;56(1):18
Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.
Yuefeng Y, Zhiqi L, Yi C, Keyu Z, Heng W, Yuying W, Ningjian W, Yuetian Y, Xinjie G, Yihao Z, Yingli L, Fangzhen X
International journal of endocrinology 2022;2022:7989751
International journal of endocrinology 2022;2022:7989751
Engineered Red Blood Cell Membrane-Coating Salidroside/Indocyanine Green Nanovesicles for High-Efficiency Hypoxic Targeting Phototherapy of Triple-Negative Breast Cancer.
Pan Y, He Y, Zhao X, Pan Y, Meng X, Lv Z, Hu Z, Mou X, Cai Y
Advanced healthcare materials 2022 Sep;11(17):e2200962
Advanced healthcare materials 2022 Sep;11(17):e2200962
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.
Perelroizen R, Philosof B, Budick-Harmelin N, Chernobylsky T, Ron A, Katzir R, Shimon D, Tessler A, Adir O, Gaoni-Yogev A, Meyer T, Krivitsky A, Shidlovsky N, Madi A, Ruppin E, Mayo L
Brain : a journal of neurology 2022 Sep 14;145(9):3288-3307
Brain : a journal of neurology 2022 Sep 14;145(9):3288-3307
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274
Food & function 2022 Oct 3;13(19):10265-10274
An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency.
Zhang R, Bu T, Cao R, Li Z, Wang C, Huang B, Wei M, Yuan L, Yang G
Journal of nanobiotechnology 2022 Oct 29;20(1):463
Journal of nanobiotechnology 2022 Oct 29;20(1):463
Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial.
Wang J, Zhao J, Yan C, Xi C, Wu C, Zhao J, Li F, Ding Y, Zhang R, Qi S, Li X, Liu C, Hou W, Chen H, Wang Y, Wu D, Chen K, Jiang H, Huang H, Liu H
Cell metabolism 2022 May 3;34(5):667-680.e6
Cell metabolism 2022 May 3;34(5):667-680.e6
Highland barley Monascus purpureus Went extract ameliorates high-fat, high-fructose, high-cholesterol diet induced nonalcoholic fatty liver disease by regulating lipid metabolism in golden hamsters.
Zhao CZ, Jiang W, Zhu YY, Wang CZ, Zhong WH, Wu G, Chen J, Zhu MN, Wu QL, Du XL, Luo YY, Li M, Wang HL, Zhao H, Ma QG, Zhong GY, Wei RR
Journal of ethnopharmacology 2022 Mar 25;286:114922
Journal of ethnopharmacology 2022 Mar 25;286:114922
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease.
Pilat D, Paumier JM, García-González L, Louis L, Stephan D, Manrique C, Khrestchatisky M, Di Pasquale E, Baranger K, Rivera S
Journal of neuroinflammation 2022 Mar 11;19(1):65
Journal of neuroinflammation 2022 Mar 11;19(1):65
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Yan S, Chen J, Zhu L, Guo T, Qin D, Hu Z, Han S, Zhou Y, Akan OD, Wang J, Luo F, Lin Q
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.
Cao X, Fang W, Li X, Wang X, Mai K, Ai Q
iScience 2022 Jul 15;25(7):104670
iScience 2022 Jul 15;25(7):104670
LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis.
Shi X, Chen Y, Liu Q, Mei X, Liu J, Tang Y, Luo R, Sun D, Ma Y, Wu W, Tu W, Zhao Y, Xu W, Ke Y, Jiang S, Huang Y, Zhang R, Wang L, Chen Y, Xia J, Pu W, Zhu H, Zuo X, Li Y, Xu J, Gao F, Wei D, Chen J, Yin W, Wang Q, Dai H, Yang L, Guo G, Cui J, Song N, Zou H, Zhao S, Distler JHW, Jin L, Wang J
Clinical and translational medicine 2022 Jan;12(1):e711
Clinical and translational medicine 2022 Jan;12(1):e711
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
Chen Y, Wu X, Zhang J, Pan G, Wang X, Guo X, Wang J, Cui X, Gao H, Cheng M, Yang J, Zhang C, Jiang F
EMBO reports 2022 Feb 3;23(3):e53373
EMBO reports 2022 Feb 3;23(3):e53373
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.
Gao SS, Shi R, Sun J, Tang Y, Zheng Z, Li JF, Li H, Zhang J, Leng Q, Xu J, Chen X, Zhao J, Sy MS, Feng L, Li C
iScience 2022 Dec 22;25(12):105481
iScience 2022 Dec 22;25(12):105481
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV, Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N, Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE
Cancer research 2022 Dec 2;82(23):4457-4473
Cancer research 2022 Dec 2;82(23):4457-4473
Fused-ring α-pyrones from intramolecular C-H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation.
Mao Y, Li J, Tang C, Ma B, Xu Z, Ke C, Feng L, Zhang H, Yao S, Dai HX, Ye Y
European journal of medicinal chemistry 2022 Dec 15;244:114866
European journal of medicinal chemistry 2022 Dec 15;244:114866
The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes.
Khan TG, Ginsburg D, Emmer BT
Journal of lipid research 2022 Aug;63(8):100248
Journal of lipid research 2022 Aug;63(8):100248
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells.
Huang Y, Tocmo R, Nauman MC, Haughan MA, Johnson JJ
Nutrients 2021 Sep 10;13(9)
Nutrients 2021 Sep 10;13(9)
Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses.
Ding S, Qi W, Xu Q, Zhao T, Li X, Yin J, Zhang R, Huo C, Zhou L, Ye L
Environmental pollution (Barking, Essex : 1987) 2021 Oct 1;286:117570
Environmental pollution (Barking, Essex : 1987) 2021 Oct 1;286:117570
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Guo X, Bao X, Wang X, Liu D, Liu P, Chi T, Ji X, Zheng Z, Chen G, Zou L
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation.
Sun Y, Ren D, Yang C, Yang W, Zhao J, Zhou Y, Jin X, Wu H
Biochimica et biophysica acta. Molecular basis of disease 2021 Nov 1;1867(11):166213
Biochimica et biophysica acta. Molecular basis of disease 2021 Nov 1;1867(11):166213
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Zhong S, Li L, Liang N, Zhang L, Xu X, Chen S, Yin H
Redox biology 2021 May;41:101919
Redox biology 2021 May;41:101919
Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling.
Ma B, Wang X, Zhang R, Niu S, Rong Z, Ni L, Di X, Han Q, Liu C
Molecular medicine reports 2021 May;23(5)
Molecular medicine reports 2021 May;23(5)
New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice.
Ma N, Fan L, Dong Y, Xu X, Yu C, Chen J, Ren J
Pharmacological research 2021 May;167:105562
Pharmacological research 2021 May;167:105562
Identification of a novel mechanism for meso-tetra (4-carboxyphenyl) porphyrin (TCPP) uptake in cancer cells.
Elzi DJ, Bauta WE, Sanchez JR, Das T, Mogare S, Zannes Fatland P, Iza M, Pertsemlidis A, Rebel VI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21427
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21427
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice.
Xu X, Dong Y, Ma N, Kong W, Yu C, Gong L, Chen J, Ren J
Metabolism: clinical and experimental 2021 Jun;119:154768
Metabolism: clinical and experimental 2021 Jun;119:154768
A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system.
Yang D, Lin T, Li C, Harrison AG, Geng T, Wang P
iScience 2021 Jun 25;24(6):102678
iScience 2021 Jun 25;24(6):102678
Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages.
Choi SH, Agatisa-Boyle C, Gonen A, Kim A, Kim J, Alekseeva E, Tsimikas S, Miller YI
Arteriosclerosis, thrombosis, and vascular biology 2021 Feb;41(2):e82-e96
Arteriosclerosis, thrombosis, and vascular biology 2021 Feb;41(2):e82-e96
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
Xu H, Xia H, Zhou S, Tang Q, Bi F
Cell death discovery 2021 Feb 26;7(1):38
Cell death discovery 2021 Feb 26;7(1):38
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R
Nature communications 2021 Feb 11;12(1):961
Nature communications 2021 Feb 11;12(1):961
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
Zhao Y, He L, Wang T, Zhu L, Yan N
Metabolites 2021 Aug 23;11(8)
Metabolites 2021 Aug 23;11(8)
MicroRNA-148a regulates low-density lipoprotein metabolism by repressing the (pro)renin receptor.
Wang N, He L, Lin H, Tan L, Sun Y, Zhang X, Danser AHJ, Lu HS, He Y, Lu X
PloS one 2020;15(5):e0225356
PloS one 2020;15(5):e0225356
A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake.
Lai W, Li D, Wang Q, Nan X, Xiang Z, Ma Y, Liu Y, Chen J, Tian J, Fang Q
International journal of nanomedicine 2020;15:1481-1498
International journal of nanomedicine 2020;15:1481-1498
Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.
Chen K, Ma Z, Yan X, Liu J, Xu W, Li Y, Dai Y, Zhang Y, Xiao H
Frontiers in pharmacology 2020;11:528
Frontiers in pharmacology 2020;11:528
Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.
Cai X, Hu B, Liu S, Liu M, Huang Y, Lei P, Zhang Z, He Z, Zhang L, Huang R
Oncology letters 2020 Oct;20(4):111
Oncology letters 2020 Oct;20(4):111
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes.
Ma B, Chen Y, Wang X, Zhang R, Niu S, Ni L, Di X, Han Q, Liu C
Lipids in health and disease 2020 May 8;19(1):88
Lipids in health and disease 2020 May 8;19(1):88
Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats.
Li S, Xu S, Zhao Y, Wang H, Feng J
Nutrients 2020 May 13;12(5)
Nutrients 2020 May 13;12(5)
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
Huang Y, Ning K, Li WW, Lin G, Hou CL, Wang MJ, Zhu YC
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1082-C1096
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1082-C1096
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia.
Wu C, Xi C, Tong J, Zhao J, Jiang H, Wang J, Wang Y, Liu H
Acta pharmaceutica Sinica. B 2019 Nov;9(6):1216-1230
Acta pharmaceutica Sinica. B 2019 Nov;9(6):1216-1230
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Yang D, Hu C, Deng X, Bai Y, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages.
Guo S, Lu J, Zhuo Y, Xiao M, Xue X, Zhong S, Shen X, Yin C, Li L, Chen Q, Zhu M, Chen B, Zhao M, Zheng L, Tao Y, Yin H
Redox biology 2019 Feb;21:101069
Redox biology 2019 Feb;21:101069
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
Cao S, Xu P, Yan J, Liu H, Liu L, Cheng L, Qiu F, Kang N
Journal of cellular biochemistry 2019 Feb;120(2):1340-1349
Journal of cellular biochemistry 2019 Feb;120(2):1340-1349
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Zhu L, Wu G, Yang X, Jia X, Li J, Bai X, Li W, Zhao Y, Li Y, Cheng W, Liu S, Jin S
Scientific reports 2019 Feb 28;9(1):3020
Scientific reports 2019 Feb 28;9(1):3020
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases.
Guo HH, Feng CL, Zhang WX, Luo ZG, Zhang HJ, Zhang TT, Ma C, Zhan Y, Li R, Wu S, Abliz Z, Li C, Li XL, Ma XL, Wang LL, Zheng WS, Han YX, Jiang JD
Nature communications 2019 Apr 30;10(1):1981
Nature communications 2019 Apr 30;10(1):1981
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
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Food & nutrition research 2018;62
Food & nutrition research 2018;62
Polydatin Improves Glucose and Lipid Metabolisms in Insulin-Resistant HepG2 Cells through the AMPK Pathway.
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Biological & pharmaceutical bulletin 2018;41(6):891-898
Biological & pharmaceutical bulletin 2018;41(6):891-898
Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain.
Zhou CC, Gao ZY, Wang J, Wu MQ, Hu S, Chen F, Liu JX, Pan H, Yan CH
Toxicology letters 2018 Oct 15;296:173-183
Toxicology letters 2018 Oct 15;296:173-183
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Idriss AA, Hu Y, Hou Z, Hu Y, Sun Q, Omer NA, Abobaker H, Ni Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
A Novel Role of Id1 in Regulating Oscillatory Shear Stress-Mediated Lipid Uptake in Endothelial Cells.
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Annals of biomedical engineering 2018 Jun;46(6):849-863
Annals of biomedical engineering 2018 Jun;46(6):849-863
In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing.
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Arteriosclerosis, thrombosis, and vascular biology 2017 Sep;37(9):1741-1747
Arteriosclerosis, thrombosis, and vascular biology 2017 Sep;37(9):1741-1747
Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop.
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Oncotarget 2017 Nov 28;8(61):103985-103995
Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells.
Bian F, Cui J, Zheng T, Jin S
International journal of molecular medicine 2017 Mar;39(3):629-635
International journal of molecular medicine 2017 Mar;39(3):629-635
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
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Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.
Cai D, Yuan M, Liu H, Pan S, Ma W, Hong J, Zhao R
Nutrients 2016 Oct 18;8(10)
Nutrients 2016 Oct 18;8(10)
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Journal of agricultural and food chemistry 2016 Oct 12;64(40):7530-7539
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Journal of virology 2016 Nov 1;90(21):9632-9643
Journal of virology 2016 Nov 1;90(21):9632-9643
Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism.
Sun L, Dong H, Zhang Z, Liu J, Hu Y, Ni Y, Grossmann R, Zhao R
Oncotarget 2016 May 10;7(19):27627-40
Oncotarget 2016 May 10;7(19):27627-40
Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats.
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Lipids in health and disease 2016 Jul 22;15(1):119
Lipids in health and disease 2016 Jul 22;15(1):119
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Liu J, Duan Y, Hu Y, Sun L, Wang S, Fu W, Ni Y, Zhao R
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2016 Jan;191:53-58
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2016 Jan;191:53-58
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Biochemical and biophysical research communications 2016 Jan 15;469(3):456-62
Biochemical and biophysical research communications 2016 Jan 15;469(3):456-62
The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation.
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Fitoterapia 2016 Dec;115:111-121
Fitoterapia 2016 Dec;115:111-121
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Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
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Lipids 2015 Feb;50(2):185-94
Lipids 2015 Feb;50(2):185-94
TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine.
Yuan ZY, Lu X, Lei F, Chai YS, Wang YG, Jiang JF, Feng TS, Wang XP, Yu X, Yan XJ, Xing DM, Du LJ
Scientific reports 2015 Dec 16;5:18326
Scientific reports 2015 Dec 16;5:18326
Cholesterol deregulation induced by chronic corticosterone (CORT) stress in pectoralis major of broiler chickens.
Duan Y, Fu W, Wang S, Ni Y, Zhao R
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2014 Oct;176:59-64
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2014 Oct;176:59-64
Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice.
Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y
Journal of cardiovascular pharmacology 2014 May;63(5):441-52
Journal of cardiovascular pharmacology 2014 May;63(5):441-52
TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.
Zhang Y, Yang X, Bian F, Wu P, Xing S, Xu G, Li W, Chi J, Ouyang C, Zheng T, Wu D, Zhang Y, Li Y, Jin S
Journal of molecular and cellular cardiology 2014 Jul;72:85-94
Journal of molecular and cellular cardiology 2014 Jul;72:85-94
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10785-1-AP(LDLR antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10785-1-AP(LDLR antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LDLR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LDLR. This antibody recognizes human, mouse antigen. The LDLR antibody has been validated for the following applications: ELISA, WB, IHC analysis.
