Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 337402 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#337402, RRID:AB_2174164
- Product name
- Purified anti-human CD112 (Nectin-2)
- Antibody type
- Monoclonal
- Antigen
- CD112 (Nectin-2)
- Description
- CD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells. CD112 functions as a receptor for α-herpes viruses HSV-1 and pseudorabies virus (PRV). CD112 is an adhesion molecule involved in the formation of cell junction and regulation of NK- and T-cells mediated cytotoxicity through interaction with CD226 (DNAM-1) and other nectin family molecules.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17858-63
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17858-63
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- KG1a (human myeloid leukemia cell line) stained with purified TX31, followed by biotinylated anti-mouse IgG and Sav-PE
- Conjugate
- Unconjugated