Explore
Validate
Learn
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AMAb90618 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#AMAb90618, RRID:AB_2665606
- Product name
- Anti-HMGCR
- Antibody type
- Monoclonal
- Description
- Monoclonal Antibody against Human HMGCR, Clone ID: CL0259, Gene description: 3-hydroxy-3-methylglutaryl-coa reductase, Validated applications: WB, IHC, Uniprot ID: P04035, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- CL0259
- Vial size
- 100 µl
- Concentration
- 0.6 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype.
Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines
Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells
The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.
Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis.
Statin use, HMGCR expression, and breast cancer survival - The Malmö Diet and Cancer Study.
Politiek FA, Turkenburg M, Ofman R, Waterham HR
Frontiers in immunology 2024;15:1379220
Frontiers in immunology 2024;15:1379220
Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines
Irie N, Mizoguchi K, Warita T, Nakano M, Sasaki K, Tashiro J, Osaki T, Ishikawa T, Oltvai Z, Warita K
Biomedicines 2024;12(3):698
Biomedicines 2024;12(3):698
Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells
Warita K, Ishikawa T, Sugiura A, Tashiro J, Shimakura H, Hosaka Y, Ohta K, Warita T, Oltvai Z
Scientific Reports 2021;11(1)
Scientific Reports 2021;11(1)
The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.
Ranea-Robles P, Chen H, Stauffer B, Yu C, Bhattacharya D, Friedman SL, Puchowicz M, Houten SM
Journal of inherited metabolic disease 2021 Nov;44(6):1419-1433
Journal of inherited metabolic disease 2021 Nov;44(6):1419-1433
Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis.
Ranea-Robles P, Violante S, Argmann C, Dodatko T, Bhattacharya D, Chen H, Yu C, Friedman SL, Puchowicz M, Houten SM
Cellular and molecular life sciences : CMLS 2021 Jul;78(14):5631-5646
Cellular and molecular life sciences : CMLS 2021 Jul;78(14):5631-5646
Statin use, HMGCR expression, and breast cancer survival - The Malmö Diet and Cancer Study.
Bjarnadottir O, Feldt M, Inasu M, Bendahl PO, Elebro K, Kimbung S, Borgquist S
Scientific reports 2020 Jan 17;10(1):558
Scientific reports 2020 Jan 17;10(1):558
No comments: Submit comment
Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in MCF-7 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-HMGCR antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human liver and skeletal muscle tissues using AMAb90618 antibody. Corresponding HMGCR RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
