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Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- AMAb90619 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#AMAb90619, RRID:AB_2665607
- Product name
- Anti-HMGCR
- Antibody type
- Monoclonal
- Description
- Monoclonal Antibody against Human HMGCR, Clone ID: CL0260, Gene description: 3-hydroxy-3-methylglutaryl-coa reductase, Validated applications: IHC, WB, Uniprot ID: P04035, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- CL0260
- Vial size
- 100 µl
- Concentration
- 1.0 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Glutamine sensing licenses cholesterol synthesis
High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer.
Garcia B, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L
The EMBO Journal 2024;43(23):5837-5856
The EMBO Journal 2024;43(23):5837-5856
High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer.
Kimbung S, Lettiero B, Feldt M, Bosch A, Borgquist S
Oncotarget 2016 Sep 13;7(37):59640-59651
Oncotarget 2016 Sep 13;7(37):59640-59651
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in MCF-7 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-HMGCR antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human liver and skeletal muscle tissues using AMAb90619 antibody. Corresponding HMGCR RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
