11703-1-AP

antibody from Proteintech Group

Targeting: MCM5 CDC46

Provider product page for 11703-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11703-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11703-1-AP, RRID:AB_2235162
Product name: MCM5 antibody
Antibody type: Polyclonal
Description: MCM5 antibody (Cat. #11703-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MCM5 protein structure - 11703-1-AP shown in red.

Submitted references Claudin18.2 promote gastric cancer proliferation by activating MCM2/5.

Zheng B, Fu M, Lou F, He Y, Zhao L, Huang X, Xie X, Tan W, Chen Q, Zhang W, Hong Y, Rong K, Lu Y, Zhan P, Tu J, Shi H, Hu T, Xiao L
Scientific reports 2026 Feb 23;16(1)

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307

Host Cell Protein MCM7 Interacts with NP1 of Minute Virus of Canines and Facilitates Viral DNA Replication.

Hei Z, Ren X, Ji K, Zhang Z, Chen B, Sun Y
Microorganisms 2025 Sep 16;13(9)

CRL4(DCAF12) regulation of MCMBP ensures optimal licensing of DNA replication.

Yadav AK, Abdirov A, Ondruskova K, Negi S, Jamrichova K, Kolarova K, Dibus N, Krejci J, Polasek-Sedlackova H, Cermak L
Nature communications 2025 Oct 27;16(1):9391

MCM5 UFMylation regulates replication origin firing and fork progression.

Li Z, Wu X, Liu L, Rao S, Liao Y, Liu M, Peng B, Zhang Q, Xia Y, Zhai Y, Takeda S, Xu X
The EMBO journal 2025 Nov;44(21):6019-6050

Comprehensive Bioinformatics and Functional Analysis Identified MCM5 Facilitates Glioblastoma Progression Through Cell Cycle Regulation.

Ye Y, Song B, Yang W, Xie Y, Zhuang D, Ruan J, Ye H, Cheng H
Biochemical genetics 2025 Nov 26;

DNA replication fork speed acts as a pacer in cortical neurogenesis.

Wang J, Kong Y, Li X, Chen D, Xiang K, Tan Y, Shi L
Nature communications 2025 Nov 18;16(1):10121

TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells.

Iwasa Y, Miyata S, Tomita T, Yokota N, Miyauchi M, Mori R, Matsushita S, Suzuki R, Saeki Y, Kawahara H
The Journal of cell biology 2025 Mar 3;224(3)

Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.

Koppenhafer SL, Geary EL, Thomas MV, Croushore EE, Zimmerman JAO, Gedminas JM, Quelle DE, Dodd RD, Gordon DJ
Cancer research communications 2025 Jun 1;5(6):1034-1048

Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.

Nie Z, Liu Y, Xu L, Wang Y, Wang M, Zhou W, Zhu H, Zhao M, Wang S, Zhang H, Geng M, Peng M, Zeng H, Zhang Y, Zhu P, Shen W
Nanomedicine (London, England) 2025 Apr;20(8):803-816

BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer.

Liu N, Wang S, Li M, Zhao N, Wang D, Zhang R, Yu M, Zhao L, Zhang S, Han F, Zhao Y, Liu Q
Pharmacological research 2024 Oct;208:107377

Melatonin promotes cell cycle progression of neural stem cells subjected to manganese via Nurr1.

Chen N, Zhou H, He B, Peng S, Ding F, Liu QH, Ma Z, Liu W, Xu B
Environmental toxicology 2024 Jul;39(7):3883-3896

CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.

Xie G, Lei B, Yin Z, Xu F, Liu X
International journal of molecular sciences 2024 Feb 29;25(5)

HROB Is Implicated in DNA Replication.

Kutz J, Schmietendorf H, Rahman SA, Opel F, Pospiech H
Genes 2024 Dec 10;15(12)

Systematic analysis of expression and prognostic significance for MCM family in head and neck squamous cell carcinoma.

Sun E, Peng L, Liu Z, Yan Z, Chen M, Zheng J
Histology and histopathology 2024 Apr;39(4):471-482

The novel peptide PFAP1 promotes primordial follicle activation by binding to MCM5.

Zhang Y, Wang H, Zhu Y, Hou X, Li X, Zhou X, Ge L, Xu J, Su Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22931

m(6) A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis.

Yang X, Bai Q, Chen W, Liang J, Wang F, Gu W, Liu L, Li Q, Chen Z, Zhou A, Long J, Tian H, Wu J, Ding X, Zhou N, Li M, Yang Y, Cai J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206744

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner.

Yang Y, Yan Y, Yin J, Tang N, Wang K, Huang L, Hu J, Feng Z, Gao Q, Huang A
Signal transduction and targeted therapy 2023 Feb 10;8(1):63

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.

Hong Y, Sun H, Hong X, Yang CP, Billadeau DD, Wang T, Deng ZH
Molecular biology reports 2022 Sep;49(9):8349-8357

The Association of R-Loop Binding Proteins Subtypes with CIN Implicates Therapeutic Strategies in Colorectal Cancer.

Zhao W, Pei Q, Zhu Y, Zhan D, Mao G, Wang M, Qiu Y, Zuo K, Pei H, Sun LQ, Wen M, Tan R
Cancers 2022 Nov 15;14(22)

ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells.

Hong X, Wang T, Du J, Hong Y, Yang CP, Xiao W, Li Y, Wang M, Sun H, Deng ZH
Scientific reports 2022 Jun 11;12(1):9700

lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5.

Jiang Y, Guo H, Tong T, Xie F, Qin X, Wang X, Chen W, Zhang J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Jan 5;30(1):448-467

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Zhao N, Gui X, Fang Q, Zhang R, Zhu W, Zhang H, Li Q, Zhou Y, Zhao J, Cui X, Gao G, Tang H, Shen N, Chen T, Song H, Shen W
Journal of nanobiotechnology 2022 Apr 2;20(1):174

MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.

Saito Y, Santosa V, Ishiguro KI, Kanemaki MT
eLife 2022 Apr 19;11

The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.

Li Z, Yin H, Shen Y, Ren M, Xu X
Ecotoxicology and environmental safety 2021 Mar 15;211:111945

LncRNA CARMN overexpression promotes prognosis and chemosensitivity of triple negative breast cancer via acting as miR143-3p host gene and inhibiting DNA replication.

Sheng X, Dai H, Du Y, Peng J, Sha R, Yang F, Zhou L, Lin Y, Xu S, Wu Y, Yin W, Lu J
Journal of experimental & clinical cancer research : CR 2021 Jun 23;40(1):205

METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.

Yang DD, Chen ZH, Yu K, Lu JH, Wu QN, Wang Y, Ju HQ, Xu RH, Liu ZX, Zeng ZL
Frontiers in oncology 2020;10:115

MCMs expression in lung cancer: implication of prognostic significance.

Liu YZ, Wang BS, Jiang YY, Cao J, Hao JJ, Zhang Y, Xu X, Cai Y, Wang MR
Journal of Cancer 2017;8(18):3641-3647

Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.

Ma Y, Fei L, Zhang M, Zhang W, Liu X, Wang C, Luo Y, Zhang H, Han Y
Oncotarget 2017 Dec 1;8(62):104813-104830

A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.

Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 11703-1-AP(MCM5 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MCM5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM5. This antibody recognizes human, mouse, rat antigen. The MCM5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11703-1-AP.pdf

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