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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14689-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14689-1-AP, RRID:AB_2091025
- Product name
- DIS3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DIS3 antibody (Cat. #14689-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.
The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis.
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species.
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization.
Ma Y, Wang J, He X, Liu Y, Zhen S, An L, Yang Q, Niu F, Wang H, An B, Tai X, Yan Z, Wu C, Yang X, Liu X
Nucleic acids research 2024 Feb 28;52(4):1878-1895
Nucleic acids research 2024 Feb 28;52(4):1878-1895
The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle.
Azam S, Armijo KS, Weindel CG, Chapman MJ, Devigne A, Nakagawa S, Hirose T, Carpenter S, Watson RO, Patrick KL
Proceedings of the National Academy of Sciences of the United States of America 2024 Feb 27;121(9):e2312587121
Proceedings of the National Academy of Sciences of the United States of America 2024 Feb 27;121(9):e2312587121
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.
Gao X, Li H, Zhang W, Wang X, Sun H, Cao Y, Zhao Y, Ji H, Yang F, Ma W, Liu Y, Yang B, Cai B
International journal of biological sciences 2022;18(7):2980-2993
International journal of biological sciences 2022;18(7):2980-2993
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, Rosano D, Mazza D, Barozzi S, Roncador M, Parmigiani G, Legube G, Parazzoli D, Cittaro D, Bedognetti D, Mondino A, Segalla S, Tonon G
The EMBO journal 2022 Nov 17;41(22):e108040
The EMBO journal 2022 Nov 17;41(22):e108040
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis.
Mehta C, Fraga de Andrade I, Matson DR, Dewey CN, Bresnick EH
Nucleic acids research 2021 Sep 20;49(16):9007-9025
Nucleic acids research 2021 Sep 20;49(16):9007-9025
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
Kawabe Y, Mori K, Yamashita T, Gotoh S, Ikeda M
The EMBO journal 2020 Oct 1;39(19):e102700
The EMBO journal 2020 Oct 1;39(19):e102700
Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species.
Snee MJ, Wilson WC, Zhu Y, Chen SY, Wilson BA, Kseib C, O'Neal J, Mahajan N, Tomasson MH, Arur S, Skeath JB
Genetics 2016 Jun;203(2):749-62
Genetics 2016 Jun;203(2):749-62
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.
Macias S, Cordiner RA, Gautier P, Plass M, Cáceres JF
Molecular cell 2015 Dec 17;60(6):873-85
Molecular cell 2015 Dec 17;60(6):873-85
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.
Chang HM, Triboulet R, Thornton JE, Gregory RI
Nature 2013 May 9;497(7448):244-8
Nature 2013 May 9;497(7448):244-8
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization.
Shi ZZ, Zhang YM, Shang L, Hao JJ, Zhang TT, Wang BS, Liang JW, Chen X, Zhang Y, Wang GQ, Wang MR, Zhang Y
BMC medical genomics 2012 Nov 16;5:52
BMC medical genomics 2012 Nov 16;5:52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14689-1-AP(DIS3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 14689-1-AP(DIS3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DIS3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DIS3. This antibody recognizes human,mouse,rat antigen. The DIS3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
