FNab00561
antibody from FineTest Biotech
Targeting: ARHGEF18
KIAA0521, MGC15913, P114-RhoGEF, p114RhoGEF
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- FNab00561 - Provider product page
- Provider
- FineTest Biotech
- Product name
- ARHGEF18 antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant protein fragment
- Description
- Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
rho/rac guanine nucleotide exchange
factor(GEF) 18- Epitope
- IgG
- Isotype
- IgG
- Vial size
- 100¦Ìg
- Concentration
- Immunogen affinity purified
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
- Handling
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
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