FNab00561

antibody from FineTest Biotech

Targeting: ARHGEF18 KIAA0521, MGC15913, P114-RhoGEF, p114RhoGEF

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ELISA

Immunohistochemistry

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Validation data

Product number: FNab00561 - Provider product page
Provider: FineTest Biotech
Product name: ARHGEF18 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: rho/rac guanine nucleotide exchange factor(GEF) 18
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

ARHGEF18 protein structure - FNab00561 shown in red.