21017-1-AP

antibody from Proteintech Group

Targeting: KLF5 BTEB2, CKLF, IKLF

Provider product page for 21017-1-AP

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Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [70]
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Product number: 21017-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21017-1-AP, RRID:AB_10696447
Product name: KLF5 antibody
Antibody type: Polyclonal
Description: KD/KO validated KLF5 antibody (Cat. #21017-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KLF5 protein structure - 21017-1-AP shown in red.

Submitted references Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance.

Chen J, Pang H, Wang J, Guo J, Huang T, Zhou H
Frontiers in cell and developmental biology 2026;14:1769023

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development.

Kobayashi W, Ruangroengkulrith S, Arslantas EN, Mohanan A, Tachibana K
Development (Cambridge, England) 2026 Jan 1;153(1)

Potential regulators and metabolic networks of muscle fatty infiltration: genomic and radiomics investigation based on 33 300 participants.

Tan J, Ding Z, Zheng J, Zhang J, Chen X, Li Z, Shi L, Chen J, Sun Y
International journal of surgery (London, England) 2026 Jan 1;112(1):472-485

Repression of EEF1D by KSHV RTA promotes viral lytic reactivation.

Xiang M, Yu L, Han C, Huang L, Dong L, Bai L, Wu S, Lan K
Journal of virology 2026 Apr 21;100(4):e0179325

Finerenone Ameliorates High Glucose-Induced Podocytes Epithelial-Mesenchymal Transition Through the Regulation of Krüppel-Like Factor 5 in Diabetic Nephropathy.

Shu J, Chen D, Chen W, Zhang X, Wang S, Chong N, Sun Z, Wang Q, Sun J, Xu Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:637-651

Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.

Eyunni S, Mannan R, Zhang Y, Young E, Zhang Q, Luo J, Pang M, Mahapatra S, Tien JC, George JM, Jaber M, Hakkani H, Carson SE, Todd AJ, Hosseini N, Gondal M, Rebernick RJ, Cao X, Su F, Wang R, Mehra R, Li J, Cieslik M, Chinnaiyan AM, Parolia A
Science (New York, N.Y.) 2025 Sep 4;389(6764):eadv2367

KLF5 facilitates lung adenocarcinoma metastasis by regulating the epithelial-mesenchymal transition pathway through RHPN2.

Zhang T, Wang RQ, Yang YB, Zhao WJ, Zhang QD, Ma XL, Guo JJ, Su Q, Shen XY, Lu YB, Su F, Hou XM
Journal of translational medicine 2025 Oct 10;23(1):1078

Magnetic engineered bone mesenchymal stem cells-derived exosomes for targeted acute lung injury therapy.

Wang Y, Huang J, An Y, Li Y, Chen S, Mei Y, Liu D, Tang Q
Stem cell research & therapy 2025 Oct 1;16(1):539

Hypoxia promotes airway differentiation in the human lung epithelium.

Dong Z, Wit N, Agarwal A, Reid AJ, Dubal D, Beier S, Mahbubani KT, Saeb-Parsy K, van den Ameele J, Nathan JA, Rawlins EL
Cell stem cell 2025 Nov 6;32(11):1705-1722.e9

Vitamin B12 as a novel USP3 deubiquitinase inhibitor suppresses cell proliferation and growth in osteosarcoma.

Shi Y, Cui J, Xiaohan L
Biochemical and biophysical research communications 2025 May 1;761:151640

FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease.

Li J, Jia K, Wang W, Pang Y, Wang H, Hao J, Zhao D, Li F
Tissue & cell 2025 Jun;94:102801

KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells.

Li Q, Liao Y, Zeng J, Hu S, Li C, Whitsett JA, Zheng Y, Luo F, Xu C, He T, Lin X, Wan H
American journal of respiratory cell and molecular biology 2025 Jun;72(6):663-677

KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling.

Xue Z, Li X, Zhou W, Teng Y
Scientific reports 2025 Jul 18;15(1):26176

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells.

Zhang Z, Xu H, He J, Hu Q, Liu Y, Xu Z, Lou W, Wu W, Zhang L, Pu N, Shi C, Xu Y, Wang W, Liu L
Cell death & disease 2025 Jan 18;16(1):28

Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis.

Zang W, Geng F, Liu J, Wang Z, Zhang S, Li Y, Lu Z, Pan Y
International journal of oral science 2025 Feb 28;17(1):15

KLF5 drives granulosa cell apoptosis and inflammatory injury in polycystic ovary syndrome via transcriptional activation of TXNIP.

Wang Y, Liu J, Jiang Y, Liu Y, Kuang H, Feng X
In vitro cellular & developmental biology. Animal 2025 Dec;61(10):1300-1310

HERVH-derived eRNA activates a super-enhancer-driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development.

Yuan L, Yu J, Xu X, Huang Y, Wei D, Hou Z, Nie H, Jing T, Liu Y, Wang B
Science advances 2025 Dec 12;11(50):eaea9074

The role of FAK in renal collecting duct in the progression from acute kidney injury to chronic kidney disease.

Gao C, He J, Wang Y, Shao G, Lin S, Liu J, Ren C, Quan Y, Ying Y, Li M, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2025 Aug;282:41-55

Identification of a novel tRNA-derived small RNA fragment, tRF-16-2YU04DE, with the potential of inhibiting endometrial cancer progression.

Hu H, Wu Y, Yuan S, Li H, Xiao S, Liu J, Li Y, Xie X, Gong Z, Zhong S, Xu H
Medical oncology (Northwood, London, England) 2025 Apr 22;42(5):173

Defining a TFAP2C-centered transcription factor network during murine peri-implantation.

Gao R, Yang G, Wang M, Xiao J, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S, Jiang C, Chen J
Developmental cell 2024 May 6;59(9):1146-1158.e6

Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.

Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J
Cancer cell 2024 May 13;42(5):869-884.e9

UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.

Li J, Liang Y, Zhou S, Chen J, Wu C
Breast cancer research : BCR 2024 Mar 11;26(1):44

KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma.

Yang Z, Peng Y, Wang Y, Yang P, Huang Z, Quan T, Xu X, Sun P, Sun Y, Lv J, Wei D, Zhou GQ
Oncogene 2024 Jun;43(23):1779-1795

Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.

Zhu M, Meglicki M, Lamba A, Wang P, Royer C, Turner K, Jauhar MA, Jones C, Child T, Coward K, Na J, Zernicka-Goetz M
Nature structural & molecular biology 2024 Jun;31(6):964-976

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J
Nature communications 2024 Jun 3;15(1):4703

Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection.

Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, Zheng N, Guerrero AM, Egan NA, Bohat R, Chen S, Zheng C, Mao X, Yi SS, Chen K, McGrail DJ, Sahni N, Shi PY, Chen Y, Xie X, Peng W
Nature communications 2024 Jan 2;15(1):109

Early growth response 1/Krüppel-like factor 5 pathway inhibitor alleviates lipopolysaccharide-induced lung injury by promoting autophagy.

Zou K, Wang C, Zhou C, Yang Y, Zeng Z
European journal of pharmacology 2024 Feb 5;964:176294

Pterosin B improves cognitive dysfunction by promoting microglia M1/M2 polarization through inhibiting Klf5/Parp14 pathway.

Zhang Y, Chen JC, Zheng JH, Cheng YZ, Weng WP, Zhong RL, Sun SL, Shi YS, Pan XD
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156152

Mir-381-3p aggravates ovariectomy-induced osteoporosis by inhibiting osteogenic differentiation through targeting KLF5/Wnt/β-catenin signaling pathway.

Zhao Y, Liu J, Zhang Y, Liang M, Li R, Song Y, Wang Y
Journal of orthopaedic surgery and research 2024 Aug 17;19(1):480

PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1.

Yuan M, Zhang C, Chen S, Ye S, Liu H, Ke H, Huang J, Liang G, Yu R, Hu T, Wu X, Lan P
Cancer letters 2024 Aug 10;597:217007

Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.

Zhang Z, Liu Y, Xu Y, Xu Z, Jia J, Jin Y, Wang W, Liu L
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):576-585

STK24 Promotes Progression of LUAD and Modulates the Immune Microenvironment.

Li Y, Liu Y, Wang K, Xue D, Huang Y, Tan Z, Chen Y
Mediators of inflammation 2023;2023:8646088

Refined expression quantitative trait locus analysis on adenocarcinoma at the gastroesophageal junction reveals susceptibility and prognostic markers.

Zhong C, Wu C, Lin Y, Lin D
Frontiers in genetics 2023;14:1180500

KLF5‑mediated expression of CARD11 promotes the progression of gastric cancer.

Li Q, Li S, Li Z, Xu H, Zhang W
Experimental and therapeutic medicine 2023 Sep;26(3):422

Epithelial cells activate fibroblasts to promote esophageal cancer development.

Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, Xi Y, Ma Y, Cheng G, Lin D, Wu C
Cancer cell 2023 May 8;41(5):903-918.e8

KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress.

Yang Y, Bhargava D, Chen X, Zhou T, Dursuk G, Jiang W, Wang J, Zong Z, Katz SI, Lomberk GA, Urrutia RA, Katz JP
Cell death & disease 2023 May 2;14(5):299

Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.

Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY
International journal of oncology 2023 Jul;63(1)

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.

Dos Santos M, Shah AM, Zhang Y, Bezprozvannaya S, Chen K, Xu L, Lin W, McAnally JR, Bassel-Duby R, Liu N, Olson EN
Nature communications 2023 Jul 19;14(1):4333

Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer.

Huang Q, Liu M, Zhang D, Lin BB, Fu X, Zhang Z, Zhang B, Dong JT
BMC medicine 2023 Feb 21;21(1):68

lncRNA ENST00000422059 promotes cell proliferation and inhibits cell apoptosis in breast cancer by regulating the miR-145-5p/KLF5 axis.

Zhu Y, Ren J, Wu X, Zhang Y, Wang Y, Xu J, Tan Q, Jiang Y, Li Y
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1892-1901

KLF5 promotes KIF1A expression through transcriptional repression of microRNA-338 in the development of pediatric neuroblastoma.

Zhou Y, Tang X, Huang Z, Wen J, Xiang Q, Liu D
Journal of pediatric surgery 2022 Sep;57(9):192-201

Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.

Wang Q, Chai L, Zhang Q, Wang J, Liu J, Chen H, Wang Y, Chen Y, Shen N, Xie X, Li M
Journal of molecular and cellular cardiology 2022 Oct;171:16-29

The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction.

Shen S, Wang J, Zhao Q, Hu Q
Bioengineered 2022 Mar;13(3):7209-7220

Histamine Deficiency Promotes Myofibroblasts Transformation from HDC-Expressing CD11b(+) Myeloid Cells in Injured Hearts Post Myocardial Infarction.

Zhu B, Zhu X, Wang X, Wu J, Ding S, Zhang W, Zou Y, Ge J, Yang X
Journal of cardiovascular translational research 2022 Jun;15(3):621-634

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing.

Wang Y, Cui Y, Liu J, Song Q, Cao M, Hou Y, Zhang X, Wang P
Alzheimer's research & therapy 2022 Jul 26;14(1):103

A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.

Fu J, Zhang X, Zheng H, Yang G, Chen Z, Yuan G
The Journal of biological chemistry 2022 Aug;298(8):102220

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.

Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749

Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection.

Hou J, Wei Y, Zou J, Jaffery R, Liang S, Zheng C, Chen K, Shi PY, Chen Y, Xie X, Peng W
Research square 2022 Aug 15;

Evaluation of Barrier Functions in Human iPSC-Derived Intestinal Epithelium.

Yamada S, Kanda Y
Methods in molecular biology (Clifton, N.J.) 2021;2367:27-35

Identification and Characterization of TF-lncRNA Regulatory Networks Involved in the Tumorigenesis and Development of Adamantinomatous Craniopharyngioma.

Xu D, Guo Y, Lei S, Guo A, Song D, Gao Q, Zhao S, Yin K, Wei Q, Zhang L, Wang X, Wang J, Zhang Q, Guo F
Frontiers in oncology 2021;11:739714

A Weighted Gene Co-Expression Network Analysis-Derived Prognostic Model for Predicting Prognosis and Immune Infiltration in Gastric Cancer.

Chen Q, Tan Y, Zhang C, Zhang Z, Pan S, An W, Xu H
Frontiers in oncology 2021;11:554779

Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes.

Kinisu M, Choi YJ, Cattoglio C, Liu K, Roux de Bezieux H, Valbuena R, Pum N, Dudoit S, Huang H, Xuan Z, Kim SY, He L
Cell reports 2021 Nov 9;37(6):109982

Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells.

Gao L, Yang X, Liang B, Jia Y, Tan S, Chen A, Cao P, Zhang Z, Zheng S, Sun L, Zhang F, Shao J
Toxicology 2021 Mar 30;452:152707

CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5.

Wang KF, Shi ZW, Dong DM
International immunopharmacology 2021 Jul;96:107704

An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice.

Muta K, Nakazawa Y, Obata Y, Inoue H, Torigoe K, Nakazawa M, Abe K, Furusu A, Miyazaki M, Yamamoto K, Koji T, Nishino T
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2021 Jul;41(4):394-403

The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.

Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ
Cell reports 2021 Jul 6;36(1):109314

Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.

Gao L, Yang X, Li Y, Wang Z, Wang S, Tan S, Chen A, Cao P, Shao J, Zhang Z, Zhang F, Zheng S
Life sciences 2021 Jan 1;264:118696

Transcription factor Kruppel-like factor 5 positively regulates the expression of AarF domain containing kinase 4.

Chen X, Liu S, Chen J, Wang X, Zhou G
Molecular biology reports 2020 Nov;47(11):8419-8427

KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells.

Li J, Zhang B, Liu M, Fu X, Ci X, A J, Fu C, Dong G, Wu R, Zhang Z, Fu L, Dong JT
Cancers 2020 Mar 21;12(3)

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.

Li Y, Kong R, Chen H, Zhao Z, Li L, Li J, Hu J, Zhang G, Pan S, Wang Y, Wang G, Chen H, Sun B
Aging 2019 Jul 21;11(14):5035-5057

mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5.

Wang W, Zhang Y, Wang L, Li J, Li Y, Yang X, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:2409-2414

The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5.

Yang D, Yu J, Liu HB, Yan XQ, Hu J, Yu Y, Guo J, Yuan Y, Du ZM
Cell death & disease 2019 Dec 2;10(12):908

Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers.

Yamada S, Kanda Y
Journal of pharmacological sciences 2019 Aug;140(4):337-344

KLF5 promotes the tumorigenesis and metastatic potential of thyroid cancer cells through the NF-κB signaling pathway.

Ma Y, Wang Q, Liu F, Ma X, Wu L, Guo F, Zhao S, Huang F, Qin G
Oncology reports 2018 Nov;40(5):2608-2618

miR-448-3p controls intracranial aneurysm by regulating KLF5 expression.

Zhang JZ, Chen D, Lv LQ, Xu Z, Li YM, Wang JY, Han KW, Yu MK, Huang CG, Hou LJ
Biochemical and biophysical research communications 2018 Nov 10;505(4):1211-1215

Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression.

Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, He R, Ma B, Zhao W, Han C
Journal of experimental & clinical cancer research : CR 2018 Jul 28;37(1):176

miR-20a-5p promotes adipogenic differentiation of murine bone marrow stromal cells via targeting Kruppel-like factor 3.

Zhu E, Zhang J, Zhou J, Yuan H, Zhao W, Wang B
Journal of molecular endocrinology 2018 Apr;60(3):225-237

DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma.

Fu RJ, He W, Wang XB, Li L, Zhao HB, Liu XY, Pang Z, Chen GQ, Huang L, Zhao KW
Cell death & disease 2017 Jul 27;8(7):e2952

Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.

Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, Wang R
Oncotarget 2017 Dec 12;8(65):109301-109318

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.

Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X
Cell research 2015 May;25(5):561-73

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The KLF5 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human KLF5. This antibody recognizes human,mouse,rat antigen. The KLF5 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21017-1-AP.pdf

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