ITIH2

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]). [supplied by OMIM, Nov 2009]

Description

Inter-alpha-trypsin inhibitor heavy chain 2

Tissue specificity

Tissue enriched (liver)

Subcell location

Golgi apparatus

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (7703316 - 7749520)

Ensembl ID

ENSG00000151655  (ver. 103.38)

Orthologs

Mouse Itih2: ENSMUSG00000037254

UniProt

P19823

neXtProt

NX_P19823

Human splice variants
Mouse splice variants

Protein structure