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- Antigen structure
- References [20]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10891-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10891-2-AP, RRID:AB_2164174
- Product name
- PLDN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PLDN antibody (Cat. #10891-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
PI4P and BLOC-1 remodel endosomal membranes into tubules.
Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1(+) cells via ciliary TGF-β signaling.
Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice.
BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor.
Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.
Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.
Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.
The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking.
BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.
The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.
BORC, a multisubunit complex that regulates lysosome positioning.
Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain.
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.
Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.
Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.
Calcagni' A, Staiano L, Zampelli N, Minopoli N, Herz NJ, Di Tullio G, Huynh T, Monfregola J, Esposito A, Cirillo C, Bajic A, Zahabiyon M, Curnock R, Polishchuk E, Parkitny L, Medina DL, Pastore N, Cullen PJ, Parenti G, De Matteis MA, Grumati P, Ballabio A
Nature communications 2023 Jul 3;14(1):3911
Nature communications 2023 Jul 3;14(1):3911
PI4P and BLOC-1 remodel endosomal membranes into tubules.
Jani RA, Di Cicco A, Keren-Kaplan T, Vale-Costa S, Hamaoui D, Hurbain I, Tsai FC, Di Marco M, Macé AS, Zhu Y, Amorim MJ, Bassereau P, Bonifacino JS, Subtil A, Marks MS, Lévy D, Raposo G, Delevoye C
The Journal of cell biology 2022 Nov 7;221(11)
The Journal of cell biology 2022 Nov 7;221(11)
Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Wells KM, He K, Pandey A, Cabello A, Zhang D, Yang J, Gomez G, Liu Y, Chang H, Li X, Zhang H, Feng X, da Costa LF, Metz R, Johnson CD, Martin CL, Skrobarczyk J, Berghman LR, Patrick KL, Leibowitz J, Ficht A, Sze SH, Song J, Qian X, Qin QM, Ficht TA, de Figueiredo P
eLife 2022 May 19;11
eLife 2022 May 19;11
Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1(+) cells via ciliary TGF-β signaling.
Xiao H, Zhang T, Li C, Cao Y, Wang L, Chen H, Li S, Guan C, Hu J, Chen D, Chen C, Lu H
eLife 2022 Apr 27;11
eLife 2022 Apr 27;11
Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice.
Borlepawar A, Schmiedel N, Eden M, Christen L, Rosskopf A, Frank D, Lüllmann-Rauch R, Frey N, Rangrez AY
Cells 2020 Oct 31;9(11)
Cells 2020 Oct 31;9(11)
BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor.
Zhang C, Hao C, Shui G, Li W
eLife 2020 Nov 12;9
eLife 2020 Nov 12;9
Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.
Ito A, Fukaya M, Saegusa S, Kobayashi E, Sugawara T, Hara Y, Yamauchi J, Okamoto H, Sakagami H
Journal of neurochemistry 2018 Oct;147(2):153-177
Journal of neurochemistry 2018 Oct;147(2):153-177
Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.
Kook S, Qi A, Wang P, Meng S, Gulleman P, Young LR, Guttentag SH
American journal of respiratory cell and molecular biology 2018 May;58(5):566-574
American journal of respiratory cell and molecular biology 2018 May;58(5):566-574
Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.
Gioria M, Pasini ME, Berruti G
Cell and tissue research 2017 Aug;369(2):413-427
Cell and tissue research 2017 Aug;369(2):413-427
The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking.
Yang W, Zhu C, Shen Y, Xu Q
Neuroscience 2016 Oct 1;333:78-91
Neuroscience 2016 Oct 1;333:78-91
BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.
Delevoye C, Heiligenstein X, Ripoll L, Gilles-Marsens F, Dennis MK, Linares RA, Derman L, Gokhale A, Morel E, Faundez V, Marks MS, Raposo G
Current biology : CB 2016 Jan 11;26(1):1-13
Current biology : CB 2016 Jan 11;26(1):1-13
The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.
Gokhale A, Mullin AP, Zlatic SA, Easley CA 4th, Merritt ME, Raj N, Larimore J, Gordon DE, Peden AA, Sanyal S, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7643-53
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7643-53
BORC, a multisubunit complex that regulates lysosome positioning.
Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino JS
Developmental cell 2015 Apr 20;33(2):176-88
Developmental cell 2015 Apr 20;33(2):176-88
Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain.
Han MH, Hu Z, Chen CY, Chen Y, Gucek M, Li Z, Markey SP
Journal of proteome research 2014 Nov 7;13(11):4567-80
Journal of proteome research 2014 Nov 7;13(11):4567-80
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.
Ryder PV, Vistein R, Gokhale A, Seaman MN, Puthenveedu MA, Faundez V
Molecular biology of the cell 2013 Jul;24(14):2269-84
Molecular biology of the cell 2013 Jul;24(14):2269-84
Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.
Zlatic SA, Grossniklaus EJ, Ryder PV, Salazar G, Mattheyses AL, Peden AA, Faundez V
Molecular biology of the cell 2013 Aug;24(15):2378-88
Molecular biology of the cell 2013 Aug;24(15):2378-88
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Gokhale A, Larimore J, Werner E, So L, Moreno-De-Luca A, Lese-Martin C, Lupashin VV, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Newell-Litwa K, Chintala S, Jenkins S, Pare JF, McGaha L, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):820-31
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):820-31
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.
Newell-Litwa K, Salazar G, Smith Y, Faundez V
Molecular biology of the cell 2009 Mar;20(5):1441-53
Molecular biology of the cell 2009 Mar;20(5):1441-53
Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.
Salazar G, Zlatic S, Craige B, Peden AA, Pohl J, Faundez V
The Journal of biological chemistry 2009 Jan 16;284(3):1790-802
The Journal of biological chemistry 2009 Jan 16;284(3):1790-802
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10891-2-AP(PLDN antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PLDN antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLDN. This antibody recognizes human, mouse, rat antigen. The PLDN antibody has been validated for the following applications: ELISA, WB, IHC analysis.
