13-1308-82

antibody from Invitrogen Antibodies

Targeting: IL6ST CD130, GP130, sGP130

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

13-1308-82

Provider

Invitrogen Antibodies

Product name

CD130 (GP130) Monoclonal Antibody (AN-G30), Biotin, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: The AN-G30 monoclonal antibody reacts with human gp130, also known as CD130. gp130 is the common receptor subunit for the IL-6 family of cytokines, including IL-6, IL-11, IL-27, Oncostatin M, and LIF. gp130 is expressed on numerous cell types, including T cells, mast cells, and epithelial cells. Soluble forms of gp130 have been isolated from human serum samples. Upon ligand binding, gp130 signals via the JAK-STAT, MAPK, and PI3 kinase pathways

Conjugate

Biotin

Antibody clone number

AN-G30

Concentration

0.5 mg/mL

References

Submitted references

Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation.

Boniface K, Diveu C, Morel F, Pedretti N, Froger J, Ravon E, Garcia M, Venereau E, Preisser L, Guignouard E, Guillet G, Dagregorio G, Pène J, Moles JP, Yssel H, Chevalier S, Bernard FX, Gascan H, Lecron JC
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 1;178(7):4615-22

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and 0.06 µg of Mouse IgG2a kappa Isotype Control Biotin (Product # 13-4724-85) (left) or 0.06 µg of Anti-Human CD130 Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.

Conjugate

Biotin