Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations [0]
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- Product number
- ABIN1383685 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human
- Isotype
- IgG
- Antibody clone number
- B-S12
- Vial size
- 200 µl
- Concentration
- 200µg/200µl
- Storage
- 2-8°C
Submitted references Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy.
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation.
Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.
Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture.
gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells.
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.
STAT3 is constitutively activated in Hodgkin cell lines.
Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors.
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
Identification of a gp130 cytokine receptor critical site involved in oncostatin M response.
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma.
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.
Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.
Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
Interleukin-6: structure-function relationships.
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses.
Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone.
Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Müller-Newen G, Harris KW
Cancer research 2004 Oct 1;64(19):6924-33
Cancer research 2004 Oct 1;64(19):6924-33
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
Giese B, Au-Yeung CK, Herrmann A, Diefenbach S, Haan C, Küster A, Wortmann SB, Roderburg C, Heinrich PC, Behrmann I, Müller-Newen G
The Journal of biological chemistry 2003 Oct 3;278(40):39205-13
The Journal of biological chemistry 2003 Oct 3;278(40):39205-13
Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation.
Ancey C, Menet E, Corbi P, Fredj S, Garcia M, Rücker-Martin C, Bescond J, Morel F, Wijdenes J, Lecron JC, Potreau D
Cardiovascular research 2003 Jul 1;59(1):78-85
Cardiovascular research 2003 Jul 1;59(1):78-85
Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.
Jover R, Bort R, Gómez-Lechón MJ, Castell JV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002 Nov;16(13):1799-801
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002 Nov;16(13):1799-801
Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture.
Ancey C, Corbi P, Froger J, Delwail A, Wijdenes J, Gascan H, Potreau D, Lecron JC
Cytokine 2002 May 21;18(4):199-205
Cytokine 2002 May 21;18(4):199-205
gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells.
Wang YD, Gu ZJ, Huang JA, Zhu YB, Zhou ZH, Xie W, Xu Y, Qiu YH, Zhang XG
International immunology 2002 Jun;14(6):599-603
International immunology 2002 Jun;14(6):599-603
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.
Voisin MB, Bitard J, Daburon S, Moreau JF, Taupin JL
The Journal of biological chemistry 2002 Apr 19;277(16):13682-92
The Journal of biological chemistry 2002 Apr 19;277(16):13682-92
STAT3 is constitutively activated in Hodgkin cell lines.
Kube D, Holtick U, Vockerodt M, Ahmadi T, Haier B, Behrmann I, Heinrich PC, Diehl V, Tesch H
Blood 2001 Aug 1;98(3):762-70
Blood 2001 Aug 1;98(3):762-70
Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors.
Gu ZJ, De Vos J, Rebouissou C, Jourdan M, Zhang XG, Rossi JF, Wijdenes J, Klein B
Leukemia 2000 Jan;14(1):188-97
Leukemia 2000 Jan;14(1):188-97
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.
Hammacher A, Wijdenes J, Hilton DJ, Nicola NA, Simpson RJ, Layton JE
The Biochemical journal 2000 Jan 1;345 Pt 1:25-32
The Biochemical journal 2000 Jan 1;345 Pt 1:25-32
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
Kurth I, Horsten U, Pflanz S, Timmermann A, Küster A, Dahmen H, Tacken I, Heinrich PC, Müller-Newen G
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 1;164(1):273-82
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 1;164(1):273-82
Identification of a gp130 cytokine receptor critical site involved in oncostatin M response.
Olivier C, Auguste P, Chabbert M, Lelièvre E, Chevalier S, Gascan H
The Journal of biological chemistry 2000 Feb 25;275(8):5648-56
The Journal of biological chemistry 2000 Feb 25;275(8):5648-56
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.
Müller-Newen G, Küster A, Wijdenes J, Schaper F, Heinrich PC
The Journal of biological chemistry 2000 Feb 18;275(7):4579-86
The Journal of biological chemistry 2000 Feb 18;275(7):4579-86
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
Kurth I, Horsten U, Pflanz S, Dahmen H, Küster A, Grötzinger J, Heinrich PC, Müller-Newen G
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 1;162(3):1480-7
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 1;162(3):1480-7
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
Kallen KJ, Grötzinger J, Lelièvre E, Vollmer P, Aasland D, Renné C, Müllberg J, Myer zum Büschenfelde KH, Gascan H, Rose-John S
The Journal of biological chemistry 1999 Apr 23;274(17):11859-67
The Journal of biological chemistry 1999 Apr 23;274(17):11859-67
A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma.
Rebouissou C, Wijdenes J, Autissier P, Tarte K, Costes V, Liautard J, Rossi JF, Brochier J, Klein B
Blood 1998 Jun 15;91(12):4727-37
Blood 1998 Jun 15;91(12):4727-37
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.
Thiel S, Behrmann I, Dittrich E, Muys L, Tavernier J, Wijdenes J, Heinrich PC, Graeve L
The Biochemical journal 1998 Feb 15;330 ( Pt 1):47-54
The Biochemical journal 1998 Feb 15;330 ( Pt 1):47-54
Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.
Autissier P, De Vos J, Liautard J, Tupitsyn N, Jacquet C, Chavdia N, Klein B, Brochier J, Gaillard JP
International immunology 1998 Dec;10(12):1881-9
International immunology 1998 Dec;10(12):1881-9
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.
Hammacher A, Richardson RT, Layton JE, Smith DK, Angus LJ, Hilton DJ, Nicola NA, Wijdenes J, Simpson RJ
The Journal of biological chemistry 1998 Aug 28;273(35):22701-7
The Journal of biological chemistry 1998 Aug 28;273(35):22701-7
Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
Horsten U, Müller-Newen G, Gerhartz C, Wollmer A, Wijdenes J, Heinrich PC, Grötzinger J
The Journal of biological chemistry 1997 Sep 19;272(38):23748-57
The Journal of biological chemistry 1997 Sep 19;272(38):23748-57
Interleukin-6: structure-function relationships.
Simpson RJ, Hammacher A, Smith DK, Matthews JM, Ward LD
Protein science : a publication of the Protein Society 1997 May;6(5):929-55
Protein science : a publication of the Protein Society 1997 May;6(5):929-55
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
Lebeau B, Montero Julian FA, Wijdenes J, Müller-Newen G, Dahmen H, Chérel M, Heinrich PC, Brailly H, Hallet MM, Godard A, Minvielle S, Jacques Y
FEBS letters 1997 Apr 28;407(2):141-7
FEBS letters 1997 Apr 28;407(2):141-7
gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses.
Fourcin M, Chevalier S, Guillet C, Robledo O, Froger J, Pouplard-Barthelaix A, Gascan H
The Journal of biological chemistry 1996 May 17;271(20):11756-60
The Journal of biological chemistry 1996 May 17;271(20):11756-60
Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone.
Puthier D, Bataille R, Barillé S, Mellerin MP, Harousseau JL, Ponzio A, Robillard N, Wijdenes J, Amiot M
Blood 1996 Dec 15;88(12):4659-66
Blood 1996 Dec 15;88(12):4659-66
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