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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 345030 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#345030, RRID:AB_2565831
- Product name
- Brilliant Violet 510™ anti-human CD366 (Tim-3)
- Antibody type
- Monoclonal
- Antigen
- Human Tim-3 fusion protein
- Description
- CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Antibody clone number
- F38-2E2
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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- BioLegend (provider)
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- Experimental details
- PHA-stimulated (three days) human peripheral blood lymphocytes were stained with anti-human CD366 (clone F38-2E2) Brilliant Violet 510™ (filled histogram) or mouse IgG1, κ Brilliant Violet 510™ isotype control (open histogram).
- Conjugate
- Green dye
