CABT-BL7601
antibody from Creative Diagnostics
Targeting: HAVCR2
CD366, FLJ14428, Tim-3, TIM3, TIMD3
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- CABT-BL7601 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-HAVCR2 Monoclonal antibody, clone 9C.3D23 [PE]
- Antibody type
- Monoclonal
- Description
- HAVCR2 is a 281 A.A Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 plays an important role in the regulation of macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Yellow dye
- Isotype
- IgG
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