RA0281

antibody from Oursmab

Targeting: HAVCR2 CD366, FLJ14428, Tim-3, TIM3, TIMD3

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0281

Provider

Oursmab

Product name

Cobolimab (Biosimilar Reference Antibody) (HAVCR2)

Antibody type

Monoclonal

Description

Cobolimab is an investigational humanized IgG4 monoclonal antibody targeting the immune checkpoint receptor TIM-3 (T-cell immunoglobulin and mucin domain-containing protein 3). It is designed to enhance anti-tumor immunity by blocking this inhibitory pathway, which is often upregulated in exhausted T cells within the tumor microenvironment. With a potent mechanism of action that involves mediating the internalization of TIM-3 (with an IC?? of 0.4464 nM), it represents a promising therapeutic strategy, particularly for solid tumors like non-small cell lung cancer (NSCLC), where it is being evaluated in clinical studies.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.