10708-1-AP

antibody from Proteintech Group

Targeting: SAT1 SAT, SSAT

Provider product page for 10708-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
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Product number: 10708-1-AP - Provider product page
Provider: Proteintech Group
Product name: SAT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SAT1 antibody (Cat. #10708-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SAT1 protein structure - 10708-1-AP shown in red.

Submitted references Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.

Zhang T, Zou R, Chen Z, Li Y, Sun X, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022

Polyamine-dependent metabolic shielding regulates alternative splicing.

Zabala-Letona A, Pujana-Vaquerizo M, Martinez-Laosa B, Ponce-Rodriguez M, Garcia-Longarte S, Mendizabal I, Gimeno A, Rogalska M, Tan J, Cabrera D, van Liempd S, Ximenez-Embun P, Espinosa S, Fagoaga-Eugui M, Peccati F, Zakrzewski M, Astobiza I, Arana-Castañares M, Cherkaoui S, Sendino M, Martín-Barros I, Ercilla A, Bozal-Basterra L, Carlevaris O, Arruabarrena-Aristorena A, Pérez-Andrés E, Santamaría-Zamorano T, Ferrer-Bonsoms JA, Carazo F, Cieśla M, Lobato C, Seoane J, Martín-Martín N, Barrio R, Sutherland JD, Aransay AM, Falcón-Pérez JM, Martínez-Pastor B, Rubio A, Blanco FJ, Hogarty MD, Morscher RJ, Berra E, Serwa RA, Jiménez-Barbero J, Jiménez-Osés G, Efeyan A, Finley L, Lizcano JM, Muñoz J, Valcarcel J, Carracedo A
Nature 2026 Mar;651(8106):819-828

The small molecule compound ETP-46321 suppresses gastric cancer progression by inducing SAT1-mediated ferroptosis and inhibiting the PI3K/AKT/mTOR pathway.

Wei Q, Wang T, Zeng R, Zhen J, Zang Y, Lu J, Ma W, Wang Q
Journal of translational medicine 2026 Mar 17;24(1)

Chemo-photothermal synergy ignites antitumor immunity via ferroptosis.

Lin J, Yang H, Zou Z, Deng L, Cai X, Chen M, Xu J, Yin W, Wen B, Xie W, Xu Q, Zhong G, Wu Z, Chen Y, Zhang R, Tian W, Zhang Y, Long Y, Li Y, Han Z, Liang Y, Ye J, Lu J, Liang Y, Dai Q, Zou F, He H, Zhong W, Zhuo Y
Signal transduction and targeted therapy 2026 Mar 17;11(1)

Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease.

Tang Y, Wang S, Wang Y, Zhang T, Liu Y, Di Y
Histochemistry and cell biology 2026 Apr 5;164(1)

Non-Pharmaceutical Interventions Based on Diet Restriction and Exercise Improve Morphology and Function of Fatty Pancreas in Male WBN/Kob-Lepr (Fa/Fa) Rats.

Minato K, Shiroya Y, Kurosaka Y, Yamauchi H, Takemori S
International journal of molecular sciences 2026 Apr 1;27(7)

Spermine: A prospective treatment for high glucose-induced myocardial fibrosis in db/db mice.

Liu Y, Liu X, Li S, Xu T, Lu Y, Wang T, Yuan H
Iranian journal of basic medical sciences 2025;28(7):907-915

Synergistic effect of regorafenib with aminoglycosides in ferroptosis-mediated liver injury.

Raja Dahar M, Zhou S, Hu H, Lei J, Zeng K, Yu L
Frontiers in pharmacology 2025;16:1586578

Uric acid-induced cardiomyocytic polyamines' insufficience: a potential mechanism mediates cardiomyocytic injury.

Lin C, Zheng Q, Yu H, Wu T, Chen L, Lin W, Pang J, Yang Y
Frontiers in endocrinology 2025;16:1504614

Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of SAT1 and GPX4 expression.

Li H, Cao F, Liu D, Tao L
Communications biology 2025 Sep 26;8(1):1367

Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics.

Bae H, Moon S, Chang M, Zhang F, Jang Y, Kim W, Kim S, Fu M, Lim J, Park S, Patel CN, Mall R, Zheng M, Man SM, Karki R
Nature communications 2025 May 27;16(1):4919

ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis.

Yan W, Cui X, Guo T, Liu N, Wang Z, Sun Y, Shang Y, Liu J, Zhu Y, Zhang Y, Chen L
Antioxidants & redox signaling 2025 Jul;43(1-3):37-55

Zhou K, Cai C, Wan R, Wang X
The journal of gene medicine 2025 Dec;27(12):e70063

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.

Zhen Q, Xu Y, Xu Y, Liu X, Zhang Y, Ye D, Han S, Liu S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599

ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis.

Chen C, Zhang Y, Wang G, Liu Y, Ye B, Zhou S, Wang K, Zheng H, Dong X, Luo C, Zhou J, Zeng K, Fang C, Shen L
Journal of translational medicine 2025 Dec 19;24(1):103

Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways.

Zhou C, Xu Z, Ding S, Li X, Wang H, He H, Sun H, Tong X, Ji T, Lyu Y, Zheng J
Journal of applied toxicology : JAT 2025 Aug;45(8):1637-1648

Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK/ERK pathway.

Liu Z, Chen H, Song Y, Chen K, Pan S, Yang S, Lu D
Frontiers in pharmacology 2024;15:1476718

Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer.

Tian W, Zhu L, Luo Y, Tang Y, Tan Q, Zou Y, Chen K, Deng X, Tang H, Li H, Cai M, Xie X, Ye F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2309903

Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway.

Ren X, Wen Y, Yuan M, Li C, Zhang J, Li S, Zhang X, Wang L, Wang S
European journal of pharmacology 2024 Sep 15;979:176820

Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice.

Chen D, Wu J, Zhang F, Lyu R, You Q, Qian Y, Cai Y, Tian X, Tao H, He Y, Nawaz W, Wu Z
EMBO molecular medicine 2024 Oct;16(10):2516-2538

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Yang G, Yang Y, Song Z, Chen L, Liu F, Li Y, Jiang S, Xue S, Pei J, Wu Y, He Y, Chu B, Wu H
Neuron 2024 Oct 23;112(20):3452-3469.e9

SAT1/ALOX15 Signaling Pathway Is Involved in Ferroptosis After Skeletal Muscle Contusion.

Yang H, Li Y, Zhu W, Feng X, Xin H, Chen H, Zhang G, Zuo M, Cong B, Shi W
International journal of molecular sciences 2024 Oct 21;25(20)

p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model.

Feng L, Wang C, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W
Neural regeneration research 2024 Oct 1;19(10):2299-2309

Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.

Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123

Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment.

Zahedi K, Barone S, Brooks M, Stewart TM, Foley JR, Nwafor A, Casero RA Jr, Soleimani M
Biomedicines 2024 Mar 13;12(3)

Inhibition of miR-9-3p facilitates ferroptosis by activating SAT1/p53 pathway in lung adenocarcinoma.

Wu A, Zhang A, Wang T, Chen J, Shi J
Translational lung cancer research 2024 Dec 31;13(12):3426-3442

Electroacupuncture Alleviates Neuropathic Pain by Suppressing Ferroptosis in Dorsal Root Ganglion via SAT1/ALOX15 Signaling.

Wan K, Jia M, Zhang H, Lan Y, Wang S, Zhang K, Wang Z, Zhu H, Zheng X, Luo Y, Pei L, Wu C, Liu Y, Li M
Molecular neurobiology 2023 Oct;60(10):6121-6132

Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.

Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T
PNAS nexus 2023 Oct;2(10):pgad306

The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.

Kaprio H, Siddiqui A, Saustila L, Heuser VD, Gardberg M
Scientific reports 2023 Mar 25;13(1):4884

A role of GABA(A) receptor α1 subunit in the hippocampus for rapid-acting antidepressant-like effects of ketamine.

Tang XH, Diao YG, Ren ZY, Zang YY, Zhang GF, Wang XM, Duan GF, Shen JC, Hashimoto K, Zhou ZQ, Yang JJ
Neuropharmacology 2023 Mar 1;225:109383

Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis.

Liang C, Zhu D, Xia W, Hong Z, Wang QS, Sun Y, Yang YC, Han SQ, Tang LL, Lou J, Wu MM, Zhang ZR
Biochimica et biophysica acta. Molecular basis of disease 2023 Jan 1;1869(1):166586

Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis.

Chen H, Tong T, Lu SY, Ji L, Xuan B, Zhao G, Yan Y, Song L, Zhao L, Xie Y, Leng X, Zhang X, Cui Y, Chen X, Xiong H, Yu T, Li X, Sun T, Wang Z, Chen J, Chen YX, Hong J, Fang JY
Cell metabolism 2023 Apr 4;35(4):651-666.e7

FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.

Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, Tang Y, Zheng Y, Wu T
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)

Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.

Li J, Sun Y, Yan R, Wu X, Zou H, Meng Y
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236

Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Halloran KM, Stenhouse C, Moses RM, Seo H, Johnson GA, Wu G, Bazer FW
Biology of reproduction 2022 May 17;106(5):865-878

Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.

Zhao J, Wu Y, Liang S, Piao X
Neuroscience 2022 Mar 1;485:78-90

DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.

Yang L, Jiang L, Sun X, Li J, Wang N, Liu X, Yao X, Zhang C, Deng H, Wang S, Yang G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113046

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus.

Jiang D, Mo G, Jiang Y, Kang B
Open life sciences 2021;16(1):39-45

ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis.

Sui X, Hu N, Zhang Z, Wang Y, Wang P, Xiu G
Pathology international 2021 Nov;71(11):741-751

Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.

Yang Q, Deng Y, Xu Y, Ding N, Wang C, Zhao X, Lou X, Li Y, Zhao H, Fang X
Gene 2019 Oct 20;716:144010

Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets.

Wu YY, Li TM, Zang LQ, Liu B, Wang GX
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Nov;107:1447-1453

SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.

Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine ML
PloS one 2015;10(12):e0144703

Polyamine pathway contributes to the pathogenesis of Parkinson disease.

Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, Clark LN, Small SA
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 28;107(39):16970-5

Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.

Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F
PloS one 2009 Oct 28;4(10):e7641

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