Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10666-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10666-1-AP, RRID:AB_2166973
- Product name
- PMM2 antibody
- Antibody type
- Polyclonal
- Description
- PMM2 antibody (Cat. #10666-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG).
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
Exploring the glycolytic cross-talk genes between inflammatory bowel disease and colorectal cancer.
N-Glycosylation Deficiency Reduces the Activation of Protein C and Disrupts Endothelial Barrier Integrity.
Fatal outcome after heart surgery in PMM2-CDG due to a rare homozygous gene variant with double effects.
Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG.
Novel variants and clinical symptoms in four new ALG3-CDG patients, review of the literature, and identification of AAGRP-ALG3 as a novel ALG3 variant with alanine and glycine-rich N-terminus.
Heterodimerization of Two Pathological Mutants Enhances the Activity of Human Phosphomannomutase2.
Lack of phosphomannomutase 2 affects Xenopus laevis morphogenesis and the non-canonical Wnt5a/Ror2 signalling.
Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.
Zhong M, Balakrishnan B, Guo AJ, Lai K
Molecular genetics and metabolism reports 2024 Mar;38:101035
Molecular genetics and metabolism reports 2024 Mar;38:101035
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
Himmelreich N, Kikul F, Zdrazilova L, Honzik T, Hecker A, Poschet G, Lüchtenborg C, Brügger B, Strahl S, Bürger F, Okun JG, Hansikova H, Thiel C
Molecular genetics and metabolism 2023 Jul;139(3):107610
Molecular genetics and metabolism 2023 Jul;139(3):107610
Exploring the glycolytic cross-talk genes between inflammatory bowel disease and colorectal cancer.
Ye C, Huang Y, Gao Y, Zhu S, Yuan J
Functional & integrative genomics 2023 Jul 10;23(3):230
Functional & integrative genomics 2023 Jul 10;23(3):230
N-Glycosylation Deficiency Reduces the Activation of Protein C and Disrupts Endothelial Barrier Integrity.
Pascreau T, Saller F, Bianchini EP, Lasne D, Bruneel A, Reperant C, Foulquier F, Denis CV, De Lonlay P, Borgel D
Thrombosis and haemostasis 2022 Sep;122(9):1469-1478
Thrombosis and haemostasis 2022 Sep;122(9):1469-1478
Fatal outcome after heart surgery in PMM2-CDG due to a rare homozygous gene variant with double effects.
Görlacher M, Panagiotou E, Himmelreich N, Hüllen A, Beedgen L, Dimitrov B, Geiger V, Zielonka M, Peters V, Strahl S, Vázquez-Jiménez J, Kerst G, Thiel C
Molecular genetics and metabolism reports 2020 Dec;25:100673
Molecular genetics and metabolism reports 2020 Dec;25:100673
Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG.
Iyer S, Sam FS, DiPrimio N, Preston G, Verheijen J, Murthy K, Parton Z, Tsang H, Lao J, Morava E, Perlstein EO
Disease models & mechanisms 2019 Nov 11;12(11)
Disease models & mechanisms 2019 Nov 11;12(11)
Novel variants and clinical symptoms in four new ALG3-CDG patients, review of the literature, and identification of AAGRP-ALG3 as a novel ALG3 variant with alanine and glycine-rich N-terminus.
Himmelreich N, Dimitrov B, Geiger V, Zielonka M, Hutter AM, Beedgen L, Hüllen A, Breuer M, Peters V, Thiemann KC, Hoffmann GF, Sinning I, Dupré T, Vuillaumier-Barrot S, Barrey C, Denecke J, Kölfen W, Düker G, Ganschow R, Lentze MJ, Moore S, Seta N, Ziegler A, Thiel C
Human mutation 2019 Jul;40(7):938-951
Human mutation 2019 Jul;40(7):938-951
Heterodimerization of Two Pathological Mutants Enhances the Activity of Human Phosphomannomutase2.
Andreotti G, Monti MC, Citro V, Cubellis MV
PloS one 2015;10(10):e0139882
PloS one 2015;10(10):e0139882
Lack of phosphomannomutase 2 affects Xenopus laevis morphogenesis and the non-canonical Wnt5a/Ror2 signalling.
Himmelreich N, Kaufmann LT, Steinbeisser H, Körner C, Thiel C
Journal of inherited metabolic disease 2015 Nov;38(6):1137-46
Journal of inherited metabolic disease 2015 Nov;38(6):1137-46
Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.
Wegrzynowicz M, Holt HK, Friedman DB, Bowman AB
Journal of proteome research 2012 Feb 3;11(2):1118-32
Journal of proteome research 2012 Feb 3;11(2):1118-32
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 10666-1-AP(PMM2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PMM2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PMM2. This antibody recognizes human,mouse,rat antigen. The PMM2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
