10135-1-AP

antibody from Proteintech Group

Targeting: VAMP2 SYB2, VAMP-2

Provider product page for 10135-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 10135-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10135-1-AP, RRID:AB_2256918
Product name: VAMP2 antibody
Antibody type: Polyclonal
Description: VAMP2 antibody (Cat. #10135-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

VAMP2 protein structure - 10135-1-AP shown in red.

Submitted references GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes.

Bindu DS, Savage JT, Brose N, Bradley L, Dimond K, Tan CX, Eroglu C
bioRxiv : the preprint server for biology 2024 Oct 10;

Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.

Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024

Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder.

Valeri J, Stiplosek C, O'Donovan SM, Sinclair D, Grant K, Bollavarapu R, Platt DM, Stockmeier CA, Gisabella B, Pantazopoulos H
medRxiv : the preprint server for health sciences 2024 Jan 2;

SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy.

Wang J, Dai L, Deng M, Xiao T, Zhang Z, Zhang Z
Molecular neurobiology 2024 Apr;61(4):2446-2458

GDF1 ameliorates cognitive impairment induced by hearing loss.

Pan L, Li C, Meng L, Zhang G, Zou L, Tian Y, Chen S, Sun Y, Su D, Zhang X, Xiong M, Xiao T, Xia D, Hong Z, Zhang Z
Nature aging 2024 Apr;4(4):568-583

Construction and validation of a risk model based on the key SNARE proteins to predict the prognosis and immune microenvironment of gliomas.

Yin L, Xu Y, Yin J, Cheng H, Xiao W, Wu Y, Ji D, Gao S
Frontiers in molecular neuroscience 2023;16:1304224

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.

Cao Q, Kumar M, Frazier A, Williams JB, Zhao S, Yan Z
Aging 2023 Nov 3;15(21):11697-11719

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage.

Raj N, Greune L, Kahms M, Mildner K, Franzkoch R, Psathaki OE, Zobel T, Zeuschner D, Klingauf J, Gerke V
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2300244

A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity.

Kim H, Song Z, Zhang R, Davies BSJ, Zhang K
Science signaling 2023 Jan 17;16(768):eadd6702

Exogenous H(2)S Attenuates Hypertension by Regulating Renin Exocytosis under Hyperglycaemic and Hyperlipidaemic Conditions.

Liu N, Li M, Liu S, Kang J, Chen L, Huang J, Wang Y, Chen H, Zhang W
International journal of molecular sciences 2023 Jan 14;24(2)

Cofilin promotes tau pathology in Alzheimer's disease.

Yan M, Tang L, Dai L, Lei C, Xiong M, Zhang X, He M, Tian Y, Xiong J, Ke W, Zhang Z, Zhang C, Deng X, Zhang Z
Cell reports 2023 Feb 28;42(2):112138

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.

Wei Y, Miao Q, Zhang Q, Mao S, Li M, Xu X, Xia X, Wei K, Fan Y, Zheng X, Fang Y, Mei M, Zhang Q, Ding J, Fan Y, Lu M, Hu G
Nature neuroscience 2023 Dec;26(12):2081-2089

Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.

Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471

Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits.

Williams JB, Cao Q, Yan Z
Brain communications 2021;3(3):fcab123

Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress.

Zhu X, Li T, Hu E, Duan L, Zhang C, Wang Y, Tang T, Yang Z, Fan R
Frontiers in pharmacology 2021;12:791097

Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy.

Ramos H, Bogdanov P, Sabater D, Huerta J, Valeri M, Hernández C, Simó R
Biomedicines 2021 Nov 26;9(12)

Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription.

Wang ZJ, Rein B, Zhong P, Williams J, Cao Q, Yang F, Zhang F, Ma K, Yan Z
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1617-1626

Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.

Pang H, Wang X, Zhao S, Xi W, Lv J, Qin J, Zhao Q, Che Y, Chen L, Li SJ
The Journal of biological chemistry 2020 Mar 13;295(11):3601-3613

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells.

Chen J, Wang F, Zhou Y, Jiang J, Ksimu S, Zhang X, Li JZ, Niu J, Wang Q
Clinical science (London, England : 1979) 2020 Mar 13;134(5):529-542

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Duan XL, Guo Z, He YT, Li YX, Liu YN, Bai HH, Li HL, Hu XD, Suo ZW
Neuroscience 2020 Mar 1;429:203-212

Engineered Cell-Derived Microparticles Bi(2)Se(3)/DOX@MPs for Imaging Guided Synergistic Photothermal/Low-Dose Chemotherapy of Cancer.

Wang D, Yao Y, He J, Zhong X, Li B, Rao S, Yu H, He S, Feng X, Xu T, Yang B, Yong T, Gan L, Hu J, Yang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Feb;7(3):1901293

Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.

Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos LV, Guillén N, Arnal C, Gascón S, Navarro MA, Rodríguez-Yoldi MJ, Busto R, Lasunción MA, Osada J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Dec;1865(12):158790

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.

Merriman C, Fu D
The Journal of biological chemistry 2019 Nov 8;294(45):16992-17006

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome.

Cagnetta R, Frese CK, Shigeoka T, Krijgsveld J, Holt CE
Neuron 2018 Jul 11;99(1):29-46.e4

Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.

Aerbajinai W, Liu L, Zhu J, Kumkhaek C, Chin K, Rodgers GP
The Journal of biological chemistry 2016 Apr 15;291(16):8549-64

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 10135-1-AP( VAMP2 Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The VAMP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VAMP2. This antibody recognizes human,mouse,rat antigen. The VAMP2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 10135-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 10135-1-AP(VAMP2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue