Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 13715-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13715-1-AP, RRID:AB_10597096
- Product name
- LSS antibody
- Antibody type
- Polyclonal
- Description
- LSS antibody (Cat. #13715-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds.
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes.
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis Via Regulating SREBP1.
Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2.
Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells.
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.
Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.
The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Zhang BC, Laursen MF, Hu L, Hazrati H, Narita R, Jensen LS, Hansen AS, Huang J, Zhang Y, Ding X, Muyesier M, Nilsson E, Banasik A, Zeiler C, Mogensen TH, Etzerodt A, Agger R, Johannsen M, Kofod-Olsen E, Paludan SR, Jakobsen MR
Nature communications 2024 Mar 29;15(1):2760
Nature communications 2024 Mar 29;15(1):2760
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Benatzy Y, Palmer MA, Lütjohann D, Ohno RI, Kampschulte N, Schebb NH, Fuhrmann DC, Snodgrass RG, Brüne B
Redox biology 2024 Jun;72:103149
Redox biology 2024 Jun;72:103149
Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes.
Bauer R, Meyer SP, Raue R, Palmer MA, Guerrero Ruiz VM, Cardamone G, Rösser S, Heffels M, Roesmann F, Wilhelm A, Lütjohann D, Zarnack K, Fuhrmann DC, Widera M, Schmid T, Brüne B
Frontiers in immunology 2023;14:1121864
Frontiers in immunology 2023;14:1121864
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
Basque A, Touaibia M, Martin LJ
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis Via Regulating SREBP1.
Ma P, Huang J, Chen B, Huang M, Xiong L, Chen J, Huang S, Liu Y
Investigative ophthalmology & visual science 2023 Dec 1;64(15):12
Investigative ophthalmology & visual science 2023 Dec 1;64(15):12
Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2.
Yang F, Jiang X, Zhu Y, Lee M, Xu Z, Zhang J, Li Q, Lin MY, Wang H, Lin Z
The Journal of investigative dermatology 2022 Oct;142(10):2687-2694.e2
The Journal of investigative dermatology 2022 Oct;142(10):2687-2694.e2
Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.
Chen X, Jin X, Huang F, Wang J, Cao X, Wang PG, Feng Y, Jiang F, Yang G
European journal of medicinal chemistry 2022 Nov 5;241:114636
European journal of medicinal chemistry 2022 Nov 5;241:114636
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
Grunkemeyer TJ, Ghosh S, Patel AM, Sajja K, Windak J, Basrur V, Kim Y, Nesvizhskii AI, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2021 Jul;297(1):100824
The Journal of biological chemistry 2021 Jul;297(1):100824
Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells.
Basque A, Nguyen HT, Touaibia M, Martin LJ
Current issues in molecular biology 2021 Dec 23;44(1):73-93
Current issues in molecular biology 2021 Dec 23;44(1):73-93
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.
Wada Y, Kikuchi A, Kaga A, Shimizu N, Ito J, Onuma R, Fujishima F, Totsune E, Sato R, Niihori T, Shirota M, Funayama R, Sato K, Nakazawa T, Nakayama K, Aoki Y, Aiba S, Nakagawa K, Kure S
PLoS genetics 2020 Feb;16(2):e1008628
PLoS genetics 2020 Feb;16(2):e1008628
Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.
Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR
Molecular pharmacology 2018 Apr;93(4):297-308
Molecular pharmacology 2018 Apr;93(4):297-308
The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Fryer LG, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M, Townley AK, Mensenkamp AR, Stephens DJ, Dallinga-Thie GM, Shoulders CC
The Journal of biological chemistry 2014 Feb 14;289(7):4244-61
The Journal of biological chemistry 2014 Feb 14;289(7):4244-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 13715-1-AP(LSS antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-LSS (IP:13715-1-AP, 3ug; Detection:13715-1-AP 1:500) with HepG2 cells lysate 2900ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LSS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LSS. This antibody recognizes human,mouse,rat antigen. The LSS antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.