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- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 18693-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18693-1-AP, RRID:AB_2138608
- Product name
- LSS antibody
- Antibody type
- Polyclonal
- Description
- LSS antibody (Cat. #18693-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
The compound LY295427 antagonizes 25-hydroxycholesterol through binding to INSIG.
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats.
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols.
Defect of LSS Disrupts Lens Development in Cataractogenesis.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Wang Y, Yang X, Dong Y, Yang X, Hou Y, Fu Q, Yan J, Du Y, Zhang Q, Zhou Y, Wu A, Chang S, Xu J, Zhang C, Hu X, Meng H, Sun W, Liu D
iScience 2026 Jan 16;29(1):114488
iScience 2026 Jan 16;29(1):114488
The compound LY295427 antagonizes 25-hydroxycholesterol through binding to INSIG.
Wen XY, Zhang DJ, He LM, Sun M, Jiang Q, Zhu Y, Song BL, Qiu WW, Lu XY
Journal of lipid research 2026 Apr;67(4):101015
Journal of lipid research 2026 Apr;67(4):101015
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats.
Song R, Lin Y, Zhang M, Liu Z, Zhang R, Zhao J, Li B
Nature communications 2025 Sep 26;16(1):8522
Nature communications 2025 Sep 26;16(1):8522
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols.
Ma MY, Deng G, Zhu WZ, Sun M, Jiang LY, Li WH, Liu YB, Guo L, Song BL, Zhao X
Cell reports 2024 Nov 26;43(11):114912
Cell reports 2024 Nov 26;43(11):114912
Defect of LSS Disrupts Lens Development in Cataractogenesis.
Zhao M, Mei T, Shang B, Zou B, Lian Q, Xu W, Wu K, Lai Y, Liu C, Wei L, Zhu J, Zhang K, Liu Y, Zhao L
Frontiers in cell and developmental biology 2021;9:788422
Frontiers in cell and developmental biology 2021;9:788422
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18693-1-AP(LSS antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 18693-1-AP(LSS antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LSS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LSS. This antibody recognizes human,mouse,rat antigen. The LSS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
