25318-1-AP

antibody from Proteintech Group

Targeting: DSP DPI, DPII, KPPS2, PPKS2

Provider product page for 25318-1-AP

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
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Validations
Western blot [1]

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Product number: 25318-1-AP - Provider product page
Provider: Proteintech Group
Product name: Desmoplakin antibody
Antibody type: Polyclonal
Description: KD/KO validated Desmoplakin antibody (Cat. #25318-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DSP protein structure - 25318-1-AP shown in red.

Submitted references iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion.

Wang F, Sun C, Wu TW, Fu Y, Fan Y, Zhao S, Huang K, Pan Z, Lu Y, Han JR, Jia S, Zeng L, Zhang S, Chen T, An S, Meng SS, Guo X, Li W, Lian H, Sun X, Hu J, Yang C, Feng S, Li P, Du L, Liu X, Piatkevich KD, Zou Y
Nature 2026 Jan;649(8096):505-514

Host desmosomal proteins interacting with human parvovirus B19 genomic DNA.

Kimura S, Fujita T, Hata Y, Ishida K, Ebina H, Fujii H, Morita E
Virus genes 2026 Feb;62(1):40-50

A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.

Yin H, Jiang H, Zhao R, Zhang Y, Fan X, Zhai X, Yang X, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118752

Cyclodextrin Counteracts Coxsackievirus-Induced Cardiac Damage by Protecting Desmosome Integrity and Suppressing Proinflammatory Cytokine Expression.

Zhao G, Zhang HM, Zhang GJ, Yang W, Küper C, McManus BM, Yang D
Microorganisms 2025 Oct 2;13(10)

Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.

Dong Y, Elgerbi A, Xie B, Han Y, Kwiatkowski AV, Choy JS, Sivasankar S
Nature communications 2025 Oct 10;16(1):9052

Liver metastasis or peritoneal metastasis: single-cell RNA sequencing reveals the organotropism in colorectal cancer is driven by distinct partial-EMT processes.

Yu C, Lu W, Wu J, Fang X, Wang X, Zhang G, Chen S, Mei Y, Chen H, Ye F, Yang H, Qian Y, Kong X, Zhang P, Wang J, Guo G, Ding K
Cancer letters 2025 Oct 1;629:217880

Mechanisms of cortical microtubule organization in epidermal keratinocytes.

Guo K, Merdes A
Cellular and molecular life sciences : CMLS 2025 May 6;82(1):193

Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes.

Gokhan I, Li X, Sendek JM, Mora Pagan AJ, Akar FG, Campbell SG
bioRxiv : the preprint server for biology 2025 May 19;

Cisd2 delays atrial aging via a modulation of calcium homeostasis that mitigates atrial myopathy.

Yeh CH, Shen ZQ, Chen LH, Seah C, Tzeng TY, Tung CY, Chiu WT, Kao CH, Tsai TF
Cell communication and signaling : CCS 2025 Aug 21;23(1):376

Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus.

Wang Y, Lu H, Cheng L, Guo W, Hu Y, Du X, Liu X, Xu M, Liu Y, Zhang Y, Xi R, Wang P, Liu X, Duan Y, Zhu J, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155856

The RhoGAP ARHGAP32 interacts with desmoplakin, and is required for desmosomal organization and assembly.

Li H, He Y, Wang Y, Xie L, Wu G, Liu X, Duan X, Zhou K, Ning W
Journal of cell science 2024 Sep 15;137(18)

Celastrol mediates CAV1 to attenuate pro-tumorigenic effects of senescent cells.

Zhang S, Zhu N, Shi YN, Zeng Q, Zhang CJ, Li HF, Qin L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155614

Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.

Petrova E, López-Gay JM, Fahrner M, Leturcq F, de Villartay JP, Barbieux C, Gonschorek P, Tsoi LC, Gudjonsson JE, Schilling O, Hovnanian A
Communications biology 2024 Feb 5;7(1):152

Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.

Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E
Biochemical and biophysical research communications 2023 Sep 10;672:72-80

Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma.

Wang J, Huang TJ, Mei Y, Luo FF, Xie DH, Peng LX, Liu BQ, Fan ML, Zhang JB, Zheng ST, Qian CN, Huang BJ
Cancer gene therapy 2023 Feb;30(2):375-387

Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation.

Zhang S, Shi YN, Gu J, He P, Ai QD, Zhou XD, Wang W, Qin L
Pharmaceutical biology 2023 Dec;61(1):1108-1119

Cis-regulatory chromatin loops analysis identifies GRHL3 as a master regulator of surface epithelium commitment.

Huang H, Liu J, Li M, Guo H, Zhu J, Zhu L, Wu S, Mo K, Huang Y, Tan J, Chen C, Wang B, Yu Y, Wang L, Liu Y, Ouyang H
Science advances 2022 Jul 15;8(28):eabo5668

CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart.

Xie W, Gao S, Yang Y, Li H, Zhou J, Chen M, Yang S, Zhang Y, Zhang L, Meng X, Xie S, Liu M, Li D, Chen Y, Zhou J
Cell reports 2022 Dec 27;41(13):111864

Long noncoding RNA LYPLAL1-AS1 regulates adipogenic differentiation of human mesenchymal stem cells by targeting desmoplakin and inhibiting the Wnt/β-catenin pathway.

Yang Y, Fan J, Xu H, Fan L, Deng L, Li J, Li D, Li H, Zhang F, Zhao RC
Cell death discovery 2021 May 15;7(1):105

Inhibition of the Growth of Breast Cancer-Associated Brain Tumors by the Osteocyte-Derived Conditioned Medium.

Sano T, Sun X, Feng Y, Liu S, Hase M, Fan Y, Zha R, Wu D, Aryal UK, Li BY, Sudo A, Yokota H
Cancers 2021 Mar 3;13(5)

Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone.

Liu S, Wu D, Sun X, Fan Y, Zha R, Jalali A, Feng Y, Li K, Sano T, Vike N, Li F, Rispoli J, Sudo A, Liu J, Robling A, Nakshatri H, Li BY, Yokota H
Bone research 2021 Jul 6;9(1):32

Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.

Wang LJ, Xue Y, Li H, Huo R, Yan Z, Wang J, Xu H, Wang J, Cao Y, Zhao JZ
Journal of cellular and molecular medicine 2020 May;24(9):4981-4991

ETV4 is a theranostic target in clear cell renal cell carcinoma that promotes metastasis by activating the pro-metastatic gene FOSL1 in a PI3K-AKT dependent manner.

Xu L, Hu H, Zheng LS, Wang MY, Mei Y, Peng LX, Qiang YY, Li CZ, Meng DF, Wang MD, Liu ZJ, Li XJ, Huang BJ, Qian CN
Cancer letters 2020 Jul 10;482:74-89

Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.

Zhang M, Wang X, Guo F, Jia Q, Liu N, Chen Y, Yan Y, Huang M, Tang H, Deng Y, Huang S, Zhou Z, Zhang L, Zhang L
Theranostics 2019;9(17):5065-5084

Lipoprotein receptor-related protein 6 is required to maintain intercalated disk integrity.

Wang X, Zou Y, Li Y, Chen Z, Yin C, Wang Y, Zhang L, Wu J, Yang C, Zhang G, Zou Y, Gong H
Genes to cells : devoted to molecular & cellular mechanisms 2019 Dec;24(12):789-800

GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.

Lin F, Xie YJ, Zhang XK, Huang TJ, Xu HF, Mei Y, Liang H, Hu H, Lin ST, Luo FF, Lang YH, Peng LX, Qian CN, Huang BJ
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Desmoplakin antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Desmoplakin. This antibody recognizes human, mouse antigen. The Desmoplakin antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 25318-1-AP.pdf

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