BICD1

This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]

Description

BICD cargo adaptor 1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (32106835 - 32383633)

Ensembl ID

ENSG00000151746  (ver. 103.38)

Orthologs

Mouse Bicd1: ENSMUSG00000003452

UniProt

Q96G01

neXtProt

NX_Q96G01

Human splice variants
Mouse splice variants

Protein structure