PRCP

gene product
HUMPCP, PCP
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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Proteintech Group
1 antibody
NovoPro Bioscience Inc.
1 antibody
Biorbyt
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antibodies-online
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LifeSpan BioSciences, Inc.
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Invitrogen Antibodies
3 antibodies
Novus Biologicals
5 antibodies
Aviva Systems Biology
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Abgent
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Atlas Antibodies
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Abnova Corporation
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R&D Systems
2 antibodies
MyBioSource
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ProSci
1 antibody
St John's Laboratory
2 antibodies
United States Biological
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Creative Diagnostics
2 antibodies
Sigma-Aldrich
2 antibodies
Creative Biolabs
1 antibody