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- References [261]
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- Product number
- 15294-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ADRP/Perilipin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ADRP/Perilipin 2 antibody (Cat. #15294-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration.
The CDO1-ACSM3 Axis Mediates Renal Tubule Lipid Deposition and Injury by Causing Mitochondrial Dysfunction in Lupus Nephritis.
Aging-Dependent Hepatic YAP1 Reduction Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease via Gut Microbiota Dysbiosis With Akkermansia muciniphila Downregulation.
Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation.
Unraveling the mechanism of tripterygium glycosides tablets-induced liver injury and the protective role of total glucosides of peony from immune-metabolic dysregulation to multi-cellular cascade.
Siah2 regulates lipid uptake in adipose tissue macrophages.
ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigenetic Reprogramming of the Asxl1/LXRα-H3K4me3 Axis.
Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replication.
Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions.
Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles.
S-adenosylmethionine and nicotinic acid suppress Hepatocellular carcinoma proliferation by targeting SLC25A4.
The Patatin-Like Phospholipase Domain-Containing 3 148M Variant Exacerbates Alcohol-Induced Liver Injury and Tumorigenesis in Mice.
Sepsis-induced lipid droplet accumulation enhances antibacterial innate immunity through mechanisms dependent on DGAT-1 and interferon-beta.
FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption.
Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.
BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling.
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Lipophagy modifies the catabolism of intracellular triglycerides by preferentially targeting small-sized lipid droplets in bovine mammary epithelial cells.
Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney.
Vascular Smooth Muscle-Specific NLRP3 Hyperactivation Drives Arterial Intimal Hyperplasia in Mice.
Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.
Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss.
YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy.
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis.
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.
Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain.
Bioinspired lipid droplets nanoplatform for periodontitis therapy: Integrated antibacterial, mitochondrial repair, and immunomodulatory functions.
DNA damage-regulated autophagy modulator 1 (DRAM1)-induced lipophagy facilitates Toxoplasma gondii nutrient acquisition and infection.
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease.
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2.
Sustained high-fat diet intake differentially regulates hepatic lipophagy and metabolic adaptation after bariatric surgery in obese rats.
Pentadecyl, an Active Component of Microalgae, Ameliorates Endoplasmic Reticulum Stress and Blue Light-Induced Cell Death in Mouse Retina-Derived 661W Cells.
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms.
Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production.
Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis.
Circadian control of hepatic ischemia/reperfusion injury via HSD17B13-mediated autophagy in hepatocytes.
AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.
Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.
Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma.
pORF3-driven biogenesis of lipid droplets facilitates HEV infectivity.
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
Aging Affects Lipid Homeostasis in Lacrimal Glands by Upregulating Lipogenesis and Changing Its Specificity.
Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2∗2 knock-in mice.
Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury.
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation.
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
"Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity".
Dietary combination of sucrose and linoleic acid increases intramyocellular lipid and impairs muscle strength in female Zucker diabetic fatty rats.
Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway.
TREM2 modulates lipid metabolism to alleviate airway inflammation in asthma: A potential therapeutic target.
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Cardiovascular dysfunction and altered lysosomal signaling in a murine model of acid sphingomyelinase deficiency.
Copper-Induced DRP1 Activation Disrupts Mitochondrial-Lipid Droplet Contact to Promote Hepatic Steatosis.
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia.
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice.
Meteorin-like protein alleviates intervertebral disc degeneration by suppressing lipid accumulation in nucleus pulposus cells via PPARα-CPT1A activation.
Hyperinsulinemic male LEW.1WR1 rats show early signs of impaired liver metabolism.
Cardiovascular Dysfunction and Altered Lysosomal Signaling in a Murine Model of Acid Sphingomyelinase Deficiency.
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Intratracheal instillation of graphene oxide with different diameters suppressed toll-like receptor 3-mediated lipid droplet biogenesis in lungs and livers of mice.
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
SIRT3 regulates CPT1a acetylation and fatty acid oxidation in renal tubular epithelial cells under diabetic condition.
Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.
Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism.
HIF1α Plays a Crucial Role in the Development of TFE3-Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis.
Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease.
HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV.
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD.
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner.
Investigation of oral toxicity of WS(2) nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy.
Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.
Uncovering the protective role of lipid droplet accumulation against acid-induced oxidative stress and cell death in osteosarcoma.
TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43(Q331K) knock-in mouse model.
Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis.
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function.
PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy.
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.
JMJD8 facilitates hepatic lipid deposition and metabolic dysfunction.
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells.
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.
Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brain.
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue.
AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria.
The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease.
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
JMJD8 Regulates Adipocyte Hypertrophy Through the Interaction With Perilipin 2.
Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice.
Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice.
Hepatocyte-Specific Yap1 Knockout Maintained the Liver Homeostasis of Lipid Metabolism in Mice.
High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.
Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD.
NR4A1-mediated regulation of lipid droplets in progesterone synthesis in goat luteal cells†.
TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD.
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve.
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1.
Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles.
Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway.
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1.
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine.
VPS4A is the selective receptor for lipophagy in mice and humans.
Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis.
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.
Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity.
Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4.
PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway.
Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2.
Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice.
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals.
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment.
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice.
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles.
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis.
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Increased FGF-21 Improves Ectopic Lipid Deposition in the Liver and Skeletal Muscle.
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis.
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Lipid droplets are a metabolic vulnerability in melanoma.
Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis.
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke.
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.
Salvianolic Acid B Reduces the Inflammation of Fat Grafts by Inhibiting the NF-Kb Signalling Pathway in Macrophages.
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.
Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells.
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α.
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Milk fat globule membrane proteins are involved in controlling the size of milk fat globules during conjugated linoleic acid-induced milk fat depression.
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention.
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Lipid droplet dynamics in healthy and pyometra-affected canine endometrium.
Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.
Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma.
Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet.
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Inflammasome Activation and Pyroptosis via a Lipid-regulated SIRT1-p53-ASC Axis in Macrophages From Male Mice and Humans.
Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules.
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans.
Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease.
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
A critical role of VMP1 in lipoprotein secretion.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration.
Zhu K, Liu Y, Min JH, Joshua V, Lin J, Li Y, Kreutzmann JC, Guo Y, Xia W, Mohammadi E, Pieber M, Suerth V, Xia Y, Andrusivova Z, Hugnot JP, Kanatani S, Uhlén P, Lundeberg J, Li X, Fancy SPJ, Sarlus H, Harris RA, Lund H
Nature neuroscience 2026 Mar;29(3):617-631
Nature neuroscience 2026 Mar;29(3):617-631
The CDO1-ACSM3 Axis Mediates Renal Tubule Lipid Deposition and Injury by Causing Mitochondrial Dysfunction in Lupus Nephritis.
Zhang Z, Liu J, Liu Y, Wang L, Li Z, Dong Y, Tian Y, Miao X, Liu Q, Zhang W, Guo H, Xing L, Yang L, Feng X, Liu S
Cells 2026 Mar 4;15(5)
Cells 2026 Mar 4;15(5)
Aging-Dependent Hepatic YAP1 Reduction Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease via Gut Microbiota Dysbiosis With Akkermansia muciniphila Downregulation.
Gao Y, Lu J, Du Z, Gong Y, Song X, Xiong Y, Yang Y, Shi X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71676
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71676
Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation.
Mir HA, Mahesh G, Palanimuthu A, Cioffi CL, Petrukhin K
bioRxiv : the preprint server for biology 2026 Mar 23;
bioRxiv : the preprint server for biology 2026 Mar 23;
Unraveling the mechanism of tripterygium glycosides tablets-induced liver injury and the protective role of total glucosides of peony from immune-metabolic dysregulation to multi-cellular cascade.
Zhang Y, Ding Z, Wang X, Shen J, Chen J, Chen L, Chen W, Lin N, Zhang Y
Chinese medicine 2026 Mar 19;21(1)
Chinese medicine 2026 Mar 19;21(1)
Siah2 regulates lipid uptake in adipose tissue macrophages.
Ghosh B, Panta PR, Scott MC, Taylor J, Beyl R, Stadler K, Floyd ZE
The Journal of biological chemistry 2026 Mar 18;302(5):111380
The Journal of biological chemistry 2026 Mar 18;302(5):111380
ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigenetic Reprogramming of the Asxl1/LXRα-H3K4me3 Axis.
Lin L, Pan Z, Wei Z, Jiang X, Lai Y, Chen M, Lin F
Journal of neuroinflammation 2026 Mar 11;23(1)
Journal of neuroinflammation 2026 Mar 11;23(1)
Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replication.
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Autophagy 2026 Jun;22(6):1351-1368
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158134
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158134
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Trends in biotechnology 2026 Jan;44(1):170-192
Trends in biotechnology 2026 Jan;44(1):170-192
S-adenosylmethionine and nicotinic acid suppress Hepatocellular carcinoma proliferation by targeting SLC25A4.
Liu WM, Zhang QQ, Ma HQ, Chen CY, Jiao YF, Yan HX, Yang LQ, Lai RT, He ZY
Biochemical pharmacology 2026 Jan;243(Pt 2):117530
Biochemical pharmacology 2026 Jan;243(Pt 2):117530
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The American journal of pathology 2026 Jan;196(1):209-222
The American journal of pathology 2026 Jan;196(1):209-222
Sepsis-induced lipid droplet accumulation enhances antibacterial innate immunity through mechanisms dependent on DGAT-1 and interferon-beta.
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Metabolism: clinical and experimental 2026 Jan;174:156389
Metabolism: clinical and experimental 2026 Jan;174:156389
FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption.
Shen Z, Qi Y, Chu M, Wu M, Feng C, Li X, Liu Z, Si L, Wang Y, Zhang J, Lu X, Lu P
Clinical and translational medicine 2026 Jan;16(1):e70563
Clinical and translational medicine 2026 Jan;16(1):e70563
Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.
Park S, Kim MJ, Shin JH, Kim E, Son M, Lee S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e12030
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e12030
BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling.
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Neuron 2026 Jan 7;114(1):67-85.e8
Neuron 2026 Jan 7;114(1):67-85.e8
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Dong K, Zhang M, Xu J, Bai X, Yang J
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
Lipophagy modifies the catabolism of intracellular triglycerides by preferentially targeting small-sized lipid droplets in bovine mammary epithelial cells.
Kang F, Yang J, Fan Y, Yang Y, Han YQ, Dai H, Han L
Journal of the science of food and agriculture 2026 Jan 15;106(1):400-409
Journal of the science of food and agriculture 2026 Jan 15;106(1):400-409
Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney.
Li YJ, Ge HY, Zhang GG, Chen HY, Xi YJ, Wang K, Huang YL, Zhang C, Fan X, Yan XQ
World journal of diabetes 2026 Feb 15;17(2):112475
World journal of diabetes 2026 Feb 15;17(2):112475
Vascular Smooth Muscle-Specific NLRP3 Hyperactivation Drives Arterial Intimal Hyperplasia in Mice.
Wang YT, Moura AK, Zuo R, Gao W, McConnell BK, Li G, Li PL, Li X, Zhang Y
Research square 2026 Feb 11;
Research square 2026 Feb 11;
Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.
Toda Robert A, McQuade A, Koppes-den Hertog SJ, Erlebach L, Kronenberg-Versteeg D, Kampmann M, Giera M, van der Kant R
Stem cell reports 2026 Feb 10;21(2):102779
Stem cell reports 2026 Feb 10;21(2):102779
Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss.
Bruzina AS, Crum BA, Goodman LA, Ng YE, Hawe RL, Call JA, Greising SM
American journal of physiology. Regulatory, integrative and comparative physiology 2026 Feb 1;330(2):R243-R260
American journal of physiology. Regulatory, integrative and comparative physiology 2026 Feb 1;330(2):R243-R260
YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy.
Chai J, Han L, Mo D, Bai Y, Yang Y, Ding Y, Chen S, Kong X, Zhu X, Xu L, Dai H, Wang W
Redox biology 2026 Apr;91:104085
Redox biology 2026 Apr;91:104085
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis.
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Nature 2026 Apr;652(8109):471-480
Nature 2026 Apr;652(8109):471-480
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.
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Nature 2026 Apr;652(8109):462-470
Nature 2026 Apr;652(8109):462-470
Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain.
Otu-Boakye S, Natarajan D, Plakkot B, Raghavendiran I, Hoppa P, Kiss T, Subramanian M, Balasubramanian P
GeroScience 2026 Apr;48(2):1735-1750
GeroScience 2026 Apr;48(2):1735-1750
Bioinspired lipid droplets nanoplatform for periodontitis therapy: Integrated antibacterial, mitochondrial repair, and immunomodulatory functions.
Wang X, Ban C, Li X, Wang J, Cao B, Wu W, Zhang Z, Su J
Materials today. Bio 2026 Apr;37:102808
Materials today. Bio 2026 Apr;37:102808
DNA damage-regulated autophagy modulator 1 (DRAM1)-induced lipophagy facilitates Toxoplasma gondii nutrient acquisition and infection.
Hou Y, Huang S, Su XZ, Lu F
Microbiological research 2026 Apr;305:128383
Microbiological research 2026 Apr;305:128383
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.
Liu Y, Huang Z, Hsu YW, Deme P, Frankenfield AM, Wu S, Zhao X, Liu H, Zhang T, Alexander EJ, Liu M, Zhang Y, Wang H, Zhou Y, Monteiro MJ, Hao L, Haughey NJ, Wang J
Nature neuroscience 2026 Apr;29(4):782-795
Nature neuroscience 2026 Apr;29(4):782-795
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease.
Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H, Liang D, Yan R
Apoptosis : an international journal on programmed cell death 2026 Apr 7;31(4)
Apoptosis : an international journal on programmed cell death 2026 Apr 7;31(4)
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2.
Zhang S, Yang S, Kong B, Zhang Q, Zhou Z, Zhao W, Wang J, Tang Y, Yao P
The Journal of nutritional biochemistry 2026 Apr 15;155:110381
The Journal of nutritional biochemistry 2026 Apr 15;155:110381
Sustained high-fat diet intake differentially regulates hepatic lipophagy and metabolic adaptation after bariatric surgery in obese rats.
Huang SY, Liao CY, Chang CW, Wu CY, Chiang PY, Chang CC, Kao WY
The Journal of nutritional biochemistry 2026 Apr 12;155:110375
The Journal of nutritional biochemistry 2026 Apr 12;155:110375
Pentadecyl, an Active Component of Microalgae, Ameliorates Endoplasmic Reticulum Stress and Blue Light-Induced Cell Death in Mouse Retina-Derived 661W Cells.
Obayashi M, Otsu W, Yamazaki K, Nakamura S, Ishikawa H, Sakata Y, Tsuboi M, Tsusaki H, Shimazawa M
Biological & pharmaceutical bulletin 2025;48(6):791-800
Biological & pharmaceutical bulletin 2025;48(6):791-800
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
Liu Q, Du Q, Yuan X, Zhang T, Li J, Xu J, Xie R
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms.
Li Z, Deng Y, Xiao F, Sun J, Zhao Q, Zheng Z, Li G
Frontiers in immunology 2025;16:1681989
Frontiers in immunology 2025;16:1681989
Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production.
Wang C, Zhang Y, Liu T, Mi Z, Shi P, Wang Z, Li W, Wang H, Liu H, Zhang F
Frontiers in immunology 2025;16:1541954
Frontiers in immunology 2025;16:1541954
Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis.
Yang Y, Hu Q, Kang H, Xie L, Hu Y, Li J, Zhao X, Zhu L, Tang W, Liu J, Lyon CJ, Wan M
Theranostics 2025;15(17):8822-8839
Theranostics 2025;15(17):8822-8839
Circadian control of hepatic ischemia/reperfusion injury via HSD17B13-mediated autophagy in hepatocytes.
Wang H, Guo M, Ren B, Zhang H, Zhang J, Qiao R, Qian L, Zhu J, Zhang S, Su W, Zhang X, Yang G, Guan Y, Chen L
Journal of hepatology 2025 Sep;83(3):750-767
Journal of hepatology 2025 Sep;83(3):750-767
AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.
Zhang X, Wang C, Chang Y, Jia H, Zhang Y, Wang Y, Wang W, Han H, Hu Y, Shao X, Wen S, Tan S, Zhang N, Hua X, Cui H, Chen X, Song J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Sep 3;33(9):4259-4275
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Sep 3;33(9):4259-4275
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R
Nature metabolism 2025 Oct;7(10):2142-2164
Nature metabolism 2025 Oct;7(10):2142-2164
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Byeon SK, Thapa C, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Schneider JA, Pandey A, Bennett DA, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J
Nature 2025 Oct;646(8087):1178-1186
Nature 2025 Oct;646(8087):1178-1186
Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.
Yu H, Chen J, Wang F, Jia D, Bi S, Mao Y, Zhang YQ, Gao TL, Yang L, Du JX, Zhou ZH, Zhu XC, Chai GS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02707
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02707
Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.
Bruzina AS, Crum BA, Raymond-Pope CJ, Call JA, Greising SM
BMC musculoskeletal disorders 2025 Oct 8;26(1):932
BMC musculoskeletal disorders 2025 Oct 8;26(1):932
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Huo N, Xu G, Zhou H, Liu Y, Li S, Yang X, Liu J, Wang W, Yang N, Zhou N
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma.
Wang H, Xiao T, Zhuang H, Liu Y, Jin K, Li J, Li J, Gao Y, Yue D, Cui W, Xu Q, Pan J, Liu K, Wang Y, Chen R, Li H
Cell reports 2025 Oct 28;44(10):116429
Cell reports 2025 Oct 28;44(10):116429
pORF3-driven biogenesis of lipid droplets facilitates HEV infectivity.
Xu LD, Zhang F, Miao C, Yu X, Zhu Y, Zhang MD, Liu S, Sridhar S, Sun Q, Neculai D, Zhang Q, Shen L, Liang T, Ye C, Huang YW, Xu P
Cell reports 2025 Oct 28;44(10):116406
Cell reports 2025 Oct 28;44(10):116406
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
Xie M, Zheng J, Yu Y, Yang Q, Zhou Z, Xue J, Wang B, Qiu Y, Zhu Z, Sun Q, Shi X, Shangguan W, Li L, Zou Z, Zhao J, Wu P
Cell reports. Medicine 2025 Oct 21;6(10):102373
Cell reports. Medicine 2025 Oct 21;6(10):102373
Aging Affects Lipid Homeostasis in Lacrimal Glands by Upregulating Lipogenesis and Changing Its Specificity.
Yuksel S, Kumar P, Krenz SE, Scholand KK, Yu Z, Ivanova A, Makarenkova HP, Hamm-Alvarez SF, Butovich IA, de Paiva CS
Investigative ophthalmology & visual science 2025 Oct 1;66(13):1
Investigative ophthalmology & visual science 2025 Oct 1;66(13):1
Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2∗2 knock-in mice.
Takami Y, Nakamura J, Katahira J, Maeda Y, Tanaka M, Kuwamura M, Okada T, Izawa T
Free radical biology & medicine 2025 Nov;239:177-188
Free radical biology & medicine 2025 Nov;239:177-188
Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury.
Luo M, Liu J, Su Y, Jiang T, Wu X, Gao P, Qin T, Wu M, Li Q, Zhang S, He B, Wang Y, Guo X, Zhou W, Zhao S, Fan J, Chen J, Yin G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e06313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e06313
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Riillo C, Parafati M, Crupi F, Fotschki B, Ragusa M, Di Vito A, Mignogna C, Mollace V, Janda E
Nutrients 2025 Nov 25;17(23)
Nutrients 2025 Nov 25;17(23)
Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation.
Yang X, Zhong H, Yu C, Cheng J, Jiang H, Wang C, Song C, Yang H
Virology journal 2025 Nov 17;22(1):378
Virology journal 2025 Nov 17;22(1):378
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445
International immunopharmacology 2025 Nov 14;165:115445
"Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity".
Zhong D, Stavrakaki I, Desai A, DeSouza T, Linskey S, Joyce S, Hatton C, Garcia D, Kassam R, Hendricks G, Reddig K, Gao G, Xie J, Gonzalez-Perez MP, Vieira AFC, Chidley CL, Haley JA, Corvera S
bioRxiv : the preprint server for biology 2025 Nov 10;
bioRxiv : the preprint server for biology 2025 Nov 10;
Dietary combination of sucrose and linoleic acid increases intramyocellular lipid and impairs muscle strength in female Zucker diabetic fatty rats.
Takikawa M, Ohminami H, Uchida T, Kitamura A, Adachi Y, Mori Y, Ohnishi K, Masuda M, Yamanaka-Okumura H, Taketani Y
Journal of clinical biochemistry and nutrition 2025 May;76(3):271-279
Journal of clinical biochemistry and nutrition 2025 May;76(3):271-279
Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway.
Zhang X, Li J, He J, Li Y, Sun D, Zhang W
International journal of biological macromolecules 2025 May;310(Pt 2):143129
International journal of biological macromolecules 2025 May;310(Pt 2):143129
TREM2 modulates lipid metabolism to alleviate airway inflammation in asthma: A potential therapeutic target.
Sun Z, Wang X, Shi C, Yu T, Xu W, Ji X, Su K, Yan H, Shan Y, Xie T, Xu J, Zhao X, Shan J
International journal of biological macromolecules 2025 May;308(Pt 2):142306
International journal of biological macromolecules 2025 May;308(Pt 2):142306
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819
Biochemical pharmacology 2025 May;235:116819
Cardiovascular dysfunction and altered lysosomal signaling in a murine model of acid sphingomyelinase deficiency.
Wang YT, Moura AK, Zuo R, Roudbari K, Hu JZ, Khan SA, Wang Z, Shentu Y, Wang M, Li PL, Hao J, Zhang Y, Li X
Journal of molecular medicine (Berlin, Germany) 2025 May;103(5):599-617
Journal of molecular medicine (Berlin, Germany) 2025 May;103(5):599-617
Copper-Induced DRP1 Activation Disrupts Mitochondrial-Lipid Droplet Contact to Promote Hepatic Steatosis.
Li Q, Su L, Guo P, Liao J, Tang Z
Journal of agricultural and food chemistry 2025 May 28;73(21):13006-13020
Journal of agricultural and food chemistry 2025 May 28;73(21):13006-13020
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia.
Wang YN, Liu S
BMC oral health 2025 May 28;25(1):823
BMC oral health 2025 May 28;25(1):823
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Wang X-T, Zhu X, Lian Z-H, Liu Q, Yan H-H, Qiu Y, Ge X-Y
mBio 2025 May 14;16(5):e0060225
mBio 2025 May 14;16(5):e0060225
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Luo S, Zhao X, Wang Y, Jiang M, Cao Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice.
Zuo R, Wang M, Wang YT, ShenTu Y, Moura AK, Zhou Y, Roudbari K, Hu JZ, Li PL, Hao J, Li X, Zhang Y
The American journal of pathology 2025 Mar;195(3):542-560
The American journal of pathology 2025 Mar;195(3):542-560
Meteorin-like protein alleviates intervertebral disc degeneration by suppressing lipid accumulation in nucleus pulposus cells via PPARα-CPT1A activation.
Huang Z, Shi M, Zhang C, Deng Z, Qin T, Wu J, Zhang X, Han W, Li S, Gao B, Xiao Y, Huang D, Ye W
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167635
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167635
Hyperinsulinemic male LEW.1WR1 rats show early signs of impaired liver metabolism.
Wimalarathne M, Bowser BL, Arul AB, Wilkerson-Vidal QC, David MA, Hunt EC, Gibson H, Robinson RAS, Love-Rutledge ST
Experimental and molecular pathology 2025 Mar;141:104955
Experimental and molecular pathology 2025 Mar;141:104955
Cardiovascular Dysfunction and Altered Lysosomal Signaling in a Murine Model of Acid Sphingomyelinase Deficiency.
Wang YT, Moura AK, Zuo R, Roudbari K, Hu JZ, Khan SA, Wang Z, Shentu Y, Wang M, Li PL, Hao J, Zhang Y, Li X
Research square 2025 Mar 20;
Research square 2025 Mar 20;
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Simwela NV, Jaecklein E, Sassetti CM, Russell DG
eLife 2025 Mar 13;13
eLife 2025 Mar 13;13
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Xie E, Wang Q, Yi H, Wang J, Liu X, Ye R, Lu L, Tian T, Chen A, Zheng G, Zhang G, Wang H
International journal of biological macromolecules 2025 Jun;312:144097
International journal of biological macromolecules 2025 Jun;312:144097
Intratracheal instillation of graphene oxide with different diameters suppressed toll-like receptor 3-mediated lipid droplet biogenesis in lungs and livers of mice.
Wang Y, Tang X, Luo S, Zhang Z, Cao Y
Toxicology research 2025 Jun;14(3):tfaf069
Toxicology research 2025 Jun;14(3):tfaf069
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Ying W, Weng W, Wang P, Pan C, Qiu J, Huang Q, Zhan G, Chen X
Journal of neuroinflammation 2025 Jun 27;22(1):167
Journal of neuroinflammation 2025 Jun 27;22(1):167
SIRT3 regulates CPT1a acetylation and fatty acid oxidation in renal tubular epithelial cells under diabetic condition.
Yang S, Wang X, Zhang Y, Ke Q, Su W, Zhou Y, Jiang L, Dai C, Wen P
Molecular biology reports 2025 Jun 16;52(1):603
Molecular biology reports 2025 Jun 16;52(1):603
Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.
Luo S, Yang M, Jiang N, Li C, Liu Y, Sun L
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):234
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):234
Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism.
Ali T, Cashion J, Hannaoui S, Ahmed-Hassan H, Schatzl H, Gilch S
JCI insight 2025 Jul 22;10(14)
JCI insight 2025 Jul 22;10(14)
HIF1α Plays a Crucial Role in the Development of TFE3-Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis.
Nishizawa H, Funasaki S, Ma W, Kubota Y, Watanabe K, Arima Y, Kuroda S, Ito T, Furuya M, Motoshima T, Nishiyama A, Mehanna S, Satou Y, Hasumi H, Jikuya R, Makiyama K, Tamura T, Oike Y, Tanaka Y, Suda T, Schmidt LS, Linehan WM, Baba M, Kamba T
Genes to cells : devoted to molecular & cellular mechanisms 2025 Jan;30(1):e13195
Genes to cells : devoted to molecular & cellular mechanisms 2025 Jan;30(1):e13195
Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease.
Zhao X, Wang S, Liu Q, Wei W, Sun X, Song H, Xu J, Zhang S, Wang H, Fu J
Clinical and translational medicine 2025 Jan;15(1):e70198
Clinical and translational medicine 2025 Jan;15(1):e70198
HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV.
Cheng Y, Jung J, Guo L, Shuboni-Mulligan DD, Chen JF, Hu W, Guo ML
Brain, behavior, and immunity 2025 Jan;123:108-122
Brain, behavior, and immunity 2025 Jan;123:108-122
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23
Veterinary research 2025 Jan 31;56(1):23
Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD.
Xu Y, Zhang Y, Sun W, Tang Q, Feng W, Xiao H, Wang J, Yuan X, Xiang M, Gao Y, Zhang H, Lu J
Scientific reports 2025 Jan 27;15(1):3399
Scientific reports 2025 Jan 27;15(1):3399
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Simwela NV, Jaecklein E, Sassetti CM, Russell DG
bioRxiv : the preprint server for biology 2025 Jan 11;
bioRxiv : the preprint server for biology 2025 Jan 11;
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Yang Z, Chen Q, Wang J, Qiu Y, Thepsuwan P, Yi Z, Heng HH, Sun Q, Chen X, Li L, He P, Zhang R, Zhang K
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner.
Chhetri A, Park C, Kim H, Manandhar L, Chuluunbaatar C, Hwang J, Wei X, Jang G, Chinbold B, Kwon HM, Lee SW, Park R
Molecular metabolism 2025 Feb;92:102080
Molecular metabolism 2025 Feb;92:102080
Investigation of oral toxicity of WS(2) nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy.
Zha X, Luo S, Wei L, Li F, Li Y, Cao Y
Journal of applied toxicology : JAT 2025 Feb;45(2):311-321
Journal of applied toxicology : JAT 2025 Feb;45(2):311-321
Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.
Teskey G, Tiwari N, Butcko AJ, Kumar A, Yadav A, Huang YM, Kelly CV, Granneman JG, Perfield JW, Mottillo EP
The Journal of biological chemistry 2025 Feb;301(2):108186
The Journal of biological chemistry 2025 Feb;301(2):108186
Uncovering the protective role of lipid droplet accumulation against acid-induced oxidative stress and cell death in osteosarcoma.
Cortini M, Ilieva E, Massari S, Bettini G, Avnet S, Baldini N
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167576
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167576
TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43(Q331K) knock-in mouse model.
Yang C, Lee GB, Hao L, Hu F
Communications biology 2025 Feb 26;8(1):315
Communications biology 2025 Feb 26;8(1):315
Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis.
Peng W, Chen S, Ma J, Wei W, Lin N, Xing J, Guo W, Li H, Zhang L, Chan K, Yen A, Zhu G, Yue J
Nature communications 2025 Feb 24;16(1):1917
Nature communications 2025 Feb 24;16(1):1917
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function.
Saunders RA, Allen WE, Pan X, Sandhu J, Lu J, Lau TK, Smolyar K, Sullivan ZA, Dulac C, Weissman JS, Zhuang X
bioRxiv : the preprint server for biology 2025 Feb 17;
bioRxiv : the preprint server for biology 2025 Feb 17;
PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.
Yang YM, Ma HB, Xiong Y, Wu Q, Gao XK
Journal of biomedical science 2025 Feb 12;32(1):20
Journal of biomedical science 2025 Feb 12;32(1):20
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
Jia Y, Xu Q, Wang P, Liu Z, Zhang R, Liu K, Ling Y, Liu Y, Chu M
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy.
Guo R, Chen MN, Lin QH, Qi HM, Wang XQ, Li BY, Wang S, Xu SJ, Zhang Y, Liu W
Inflammation 2025 Dec;48(6):4094-4109
Inflammation 2025 Dec;48(6):4094-4109
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
Zhan S, Wang X, Wang C, Zhu B, Gao J, Peng Z, Wang R, Yang Y, Zhang L, Wang T, Wu J, Wu W, Huang K, Dong G, Ren Q, Wang S, Wang S, Zhou X, Xu L, Fu J, Guo X
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.
Joshi AS, Tomaz da Silva M, Vuong AT, Xu B, Singh RK, Kumar A
EMBO molecular medicine 2025 Dec;17(12):3607-3635
EMBO molecular medicine 2025 Dec;17(12):3607-3635
JMJD8 facilitates hepatic lipid deposition and metabolic dysfunction.
You D, Ren H, Jung BC, Oh NY, Wang L, Maschek JA, Summers SA, Kang S
American journal of physiology. Endocrinology and metabolism 2025 Dec 1;329(6):E839-E848
American journal of physiology. Endocrinology and metabolism 2025 Dec 1;329(6):E839-E848
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Yu JT, Hu XW, Wang JN, Yang Q, Li XY, Shan RR, Pu T, Hou R, Shen XY, Wang YQ, Zhang F, Yu XW, Wang J, Li FH, Wen JG, Fan Y, Jin J, Jiang YY, Meng XM
Nature communications 2025 Dec 1;17(1):30
Nature communications 2025 Dec 1;17(1):30
Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells.
Wang YT, Moura AK, Zuo R, Wang Z, Roudbari K, Hu JZ, Wang M, Li PL, Zhang Y, Li X
Cell death discovery 2025 Aug 9;11(1):374
Cell death discovery 2025 Aug 9;11(1):374
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.
Joshi AS, Tomaz da Silva M, Vuong AT, Xu B, Singh RK, Kumar A
bioRxiv : the preprint server for biology 2025 Aug 4;
bioRxiv : the preprint server for biology 2025 Aug 4;
Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brain.
Otu-Boakye S, Natarajan D, Plakkot B, Raghavendiran I, Kiss T, Subramanian M, Balasubramanian P
bioRxiv : the preprint server for biology 2025 Aug 28;
bioRxiv : the preprint server for biology 2025 Aug 28;
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue.
Saunders RA, Allen WE, Pan X, Sandhu J, Lu J, Lau TK, Smolyar K, Sullivan ZA, Dulac C, Weissman JS, Zhuang X
Cell 2025 Aug 21;188(17):4790-4809.e22
Cell 2025 Aug 21;188(17):4790-4809.e22
AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria.
Chen L, Liu Y, Zhang J, Song T, Wu J, Ren Z
Cell death & disease 2025 Aug 18;16(1):623
Cell death & disease 2025 Aug 18;16(1):623
The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease.
Thimme Gowda C, Siraganahalli Eshwaraiah M, Wang J, Lim Y, Tomasi ML, Mavila N, Ramani K
Signal transduction and targeted therapy 2025 Apr 9;10(1):109
Signal transduction and targeted therapy 2025 Apr 9;10(1):109
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
Yue R, Yan Z, Zha H, Xia Y, Huang H, Li H, Ding M, Abdullah MMH, Hu B, Shi L, Zhu J, Song Z
International immunopharmacology 2025 Apr 16;152:114342
International immunopharmacology 2025 Apr 16;152:114342
JMJD8 Regulates Adipocyte Hypertrophy Through the Interaction With Perilipin 2.
You D, Kang S
Diabetes 2025 Apr 1;74(4):458-471
Diabetes 2025 Apr 1;74(4):458-471
Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice.
Takahashi N, Ichii O, Hiraishi M, Namba T, Otani Y, Nakamura T, Kon Y
PloS one 2024;19(4):e0302041
PloS one 2024;19(4):e0302041
Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice.
Wang C, An T, Lu C, Liu T, Shan X, Zhu Z, Gao Y
Drug design, development and therapy 2024;18:2951-2969
Drug design, development and therapy 2024;18:2951-2969
Hepatocyte-Specific Yap1 Knockout Maintained the Liver Homeostasis of Lipid Metabolism in Mice.
Li C, Xue Y, Liu Y, Zheng K, Gao Y, Gong Y, Lu J, Zhang Y, Ji J, Zhang Z, Shi X
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3197-3214
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3197-3214
High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.
Amer J, Amleh A, Salhab A, Kolodny Y, Yochelis S, Saffouri B, Paltiel Y, Safadi R
Frontiers in nutrition 2024;11:1469952
Frontiers in nutrition 2024;11:1469952
Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD.
Wang J, Wang R, Li Y, Huang J, Liu Y, Wang J, Xian P, Zhang Y, Yang Y, Zhang H, Li J
Cell reports. Medicine 2024 Sep 17;5(9):101732
Cell reports. Medicine 2024 Sep 17;5(9):101732
NR4A1-mediated regulation of lipid droplets in progesterone synthesis in goat luteal cells†.
Yu H, Li X, Zhao J, Wang W, Wei Q, Mao D
Biology of reproduction 2024 Sep 14;111(3):640-654
Biology of reproduction 2024 Sep 14;111(3):640-654
TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD.
Sun B, Ding X, Tan J, Zhang J, Chu X, Zhang S, Liu S, Zhao Z, Xuan S, Xin Y, Zhuang L
Clinical and molecular hepatology 2024 Oct;30(4):863-882
Clinical and molecular hepatology 2024 Oct;30(4):863-882
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve.
Asadollahi E, Trevisiol A, Saab AS, Looser ZJ, Dibaj P, Ebrahimi R, Kusch K, Ruhwedel T, Möbius W, Jahn O, Lee JY, Don AS, Khalil MA, Hiller K, Baes M, Weber B, Abel ED, Ballabio A, Popko B, Kassmann CM, Ehrenreich H, Hirrlinger J, Nave KA
Nature neuroscience 2024 Oct;27(10):1934-1944
Nature neuroscience 2024 Oct;27(10):1934-1944
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
Yu C, Liu J, Sakurai R, Wang Y, Afrose L, Gour A, Sharma A, Chandan G, Rehan VK
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1.
Hu Y, Ye S, Kong J, Zhou Q, Wang Z, Zhang Y, Yan H, Wang Y, Li T, Xie Y, Chen B, Zhao Y, Zhang T, Zheng X, Niu J, Hu B, Wang S, Chen Z, Zheng C
Cell communication and signaling : CCS 2024 Oct 25;22(1):519
Cell communication and signaling : CCS 2024 Oct 25;22(1):519
Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles.
Huynh TN, Fikse EN, Havrda MC, Chang CCY, Chang TY
bioRxiv : the preprint server for biology 2024 Oct 25;
bioRxiv : the preprint server for biology 2024 Oct 25;
Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway.
Zhao J, Gao G, Ding J, Liu W, Wang T, Zhao L, Xu J, Zhang Z, Zhang X, Xie Z
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21548-21559
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21548-21559
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1.
Huynh TN, Havrda MC, Zanazzi GJ, Chang CCY, Chang TY
Biomolecules 2024 Oct 14;14(10)
Biomolecules 2024 Oct 14;14(10)
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Liu C, Wu C, Zhang S, Lv Z
Experimental gerontology 2024 Oct 1;195:112528
Experimental gerontology 2024 Oct 1;195:112528
TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
Zhang Z, Li Z, Peng Y, Li Z, Xv N, Jin L, Cao Y, Jiang C, Chen Z
Experimental neurology 2024 Nov;381:114916
Experimental neurology 2024 Nov;381:114916
A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine.
Willemsen S, Yengej FAY, Puschhof J, Rookmaaker MB, Verhaar MC, van Es J, Beumer J, Clevers H
Proceedings of the National Academy of Sciences of the United States of America 2024 Nov 5;121(45):e2411189121
Proceedings of the National Academy of Sciences of the United States of America 2024 Nov 5;121(45):e2411189121
VPS4A is the selective receptor for lipophagy in mice and humans.
Das D, Sharma M, Gahlot D, Nia SS, Gain C, Mecklenburg M, Zhou ZH, Bourdenx M, Thukral L, Martinez-Lopez N, Singh R
Molecular cell 2024 Nov 21;84(22):4436-4453.e8
Molecular cell 2024 Nov 21;84(22):4436-4453.e8
Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.
Rao Z, Liu S, Li Z, Wang Q, Gao F, Peng H, Ren D, Zang Y, Li H, Li Y, Hu Q, He D, Xu H
Immunity 2024 Nov 12;57(11):2514-2529.e7
Immunity 2024 Nov 12;57(11):2514-2529.e7
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
Chen X, Ruiz-Velasco A, Zou Z, Hille SS, Ross C, Fonseka O, Gare SR, Alatawi NHO, Raja R, Zhang J, Kaur N, Zhao X, Morrell-Davies H, Miller JM, Abouleisa RRE, Ou Q, Frank D, Rutter MK, Pinali C, Wang T, Mohamed TMA, Müller OJ, Liu W
Diabetes 2024 Nov 1;73(11):1805-1820
Diabetes 2024 Nov 1;73(11):1805-1820
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis.
Hauck AK, Mehmood R, Carpenter BJ, Frankfurter MT, Tackenberg MC, Inoue SI, Krieg MK, Cassim Bawa FN, Midha MK, Zundell DM, Batmanov K, Lazar MA
Nature metabolism 2024 May;6(5):825-836
Nature metabolism 2024 May;6(5):825-836
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J
Cancer cell 2024 May 13;42(5):869-884.e9
Cancer cell 2024 May 13;42(5):869-884.e9
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769
Metabolism: clinical and experimental 2024 Mar;152:155769
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Qu H, Liu X, Zhu J, Xiong X, Li L, He Q, Wang Y, Yang G, Zhang L, Yang Q, Luo G, Zheng Y, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Xiong Q, Sun H, Wang Y, Xu Q, Zhang Y, Xu M, Zhao Z, Li P, Wu C
Lipids in health and disease 2024 Mar 28;23(1):91
Lipids in health and disease 2024 Mar 28;23(1):91
Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.
Grubaugh CR, Dhingra A, Prakash B, Montenegro D, Sparrow JR, Daniele LL, Curcio CA, Bell BA, Hussain MM, Boesze-Battaglia K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23522
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23522
Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
Pei J, Zou D, Li L, Kang L, Sun M, Li X, Chen Q, Chen D, Qu B, Gao X, Lin Z
The Journal of biological chemistry 2024 Jun;300(6):107319
The Journal of biological chemistry 2024 Jun;300(6):107319
ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity.
Kovacevic I, Schmidt PH, Kowalski A, Helms BJ, Lest CHAV, Kluttig A, Posern G
Cell communication and signaling : CCS 2024 Jun 3;22(1):304
Cell communication and signaling : CCS 2024 Jun 3;22(1):304
Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
Parafati M, La Russa D, Lascala A, Crupi F, Riillo C, Fotschki B, Mollace V, Janda E
Antioxidants (Basel, Switzerland) 2024 Jun 25;13(7)
Antioxidants (Basel, Switzerland) 2024 Jun 25;13(7)
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4.
Feringa FM, Hertog SJK, Wang L, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward M, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R
bioRxiv : the preprint server for biology 2024 Jul 3;
bioRxiv : the preprint server for biology 2024 Jul 3;
PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway.
Yang K, Yu X, Guo Z, Fang Z, Zhang H, Zhang W, Liu C, Ji Y, Dong Z, Gu Q, Yao J, Liu C
Life sciences 2024 Jul 15;349:122714
Life sciences 2024 Jul 15;349:122714
Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2.
Xue Y, Lu J, Liu Y, Gao Y, Gong Y, Yang Y, Xiong Y, Shi X
Heliyon 2024 Jul 15;10(13):e33370
Heliyon 2024 Jul 15;10(13):e33370
Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice.
Wang YT, Moura AK, Zuo R, Zhou W, Wang Z, Roudbari K, Hu JZ, Li PL, Zhang Y, Li X
bioRxiv : the preprint server for biology 2024 Jul 12;
bioRxiv : the preprint server for biology 2024 Jul 12;
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Tzur Y, Winek K, Madrer N, Dubnov S, Bennett ER, Greenberg DS, Hanin G, Gammal A, Tam J, Arkin IT, Paldor I, Soreq H
Molecular metabolism 2024 Jan;79:101856
Molecular metabolism 2024 Jan;79:101856
Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals.
Guo ML, Cheng Y, Pineda DM, Dempsey RE, Yang L
Aging and disease 2024 Jan 25;16(1):454-468
Aging and disease 2024 Jan 25;16(1):454-468
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.
Ghosh S, Bandyopadhyay S, Smith DM, Adak S, Semenkovich CF, Nagy L, Wolfgang MJ, O'Connor TJ
PLoS pathogens 2024 Feb;20(2):e1011996
PLoS pathogens 2024 Feb;20(2):e1011996
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.
Guan X, Wu J, Geng J, Ji D, Wei D, Ling Y, Zhang Y, Jiang G, Pang T, Huang Z
Translational stroke research 2024 Feb;15(1):195-218
Translational stroke research 2024 Feb;15(1):195-218
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment.
Chen Y, Tao J, He Y, Hou X, Fang J, Huang J, Wang L, Shen J, Zhu B, Wang N, Cao A
Archives of pharmacal research 2024 Dec;47(12):924-939
Archives of pharmacal research 2024 Dec;47(12):924-939
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
Xu M, Chen ZY, Li Y, Li Y, Guo G, Dai RZ, Ni N, Tao J, Wang HY, Chen QL, Wang H, Zhou H, Yang YN, Chen S, Chen L
The EMBO journal 2024 Dec;43(24):6383-6409
The EMBO journal 2024 Dec;43(24):6383-6409
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
Otkur W, Zhang Y, Li Y, Bao W, Feng T, Wu B, Ma Y, Shi J, Wang L, Pei S, Wang W, Wang J, Zhao Y, Liu Y, Li X, Xia T, Wang F, Chen D, Liang X, Piao HL
Life metabolism 2024 Dec;3(6):loae021
Life metabolism 2024 Dec;3(6):loae021
Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria.
Hirata Y, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, Niijima T, Toyama T, Kise R, Sato E, Uchida Y, Ito J, Nakagawa K, Taguchi T, Inoue A, Saito Y, Noguchi T, Matsuzawa A
Cell death & disease 2024 Dec 6;15(12):884
Cell death & disease 2024 Dec 6;15(12):884
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice.
Wang YT, Moura AK, Zuo R, Zhou W, Wang Z, Roudbari K, Hu JZ, Li PL, Zhang Y, Li X
Journal of the American Heart Association 2024 Dec 3;13(23):e037460
Journal of the American Heart Association 2024 Dec 3;13(23):e037460
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles.
Huynh TN, Fikse EN, De La Torre AL, Havrda MC, Chang CCY, Chang TY
International journal of molecular sciences 2024 Dec 21;25(24)
International journal of molecular sciences 2024 Dec 21;25(24)
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
Lu J, Zhou H, Hu J, Zhang R, Meng Z, Guan S
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Liu J, Xu D, Yan J, Wang B, Zhang L, Liu X, Zhang H, Yan G, Yang J, Zeng Q, Wang X
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson PK, Yip O, Dong W, Rawat E, West E, Schlachetzki JCM, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T
Nature 2024 Apr;628(8006):154-161
Nature 2024 Apr;628(8006):154-161
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
Li GL, Han YQ, Su BQ, Yu HS, Zhang S, Yang GY, Wang J, Liu F, Ming SL, Chu BB
PLoS pathogens 2024 Apr;20(4):e1012123
PLoS pathogens 2024 Apr;20(4):e1012123
GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis.
Shen R, Qin S, Lv Y, Liu D, Ke Q, Shi C, Jiang L, Yang J, Zhou Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167060
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167060
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Zhong D, Chen J, Qiao R, Song C, Hao C, Zou Y, Bai M, Su W, Yang B, Sun D, Jia Z, Sun Y
Cell reports 2024 Apr 23;43(4):114075
Cell reports 2024 Apr 23;43(4):114075
Increased FGF-21 Improves Ectopic Lipid Deposition in the Liver and Skeletal Muscle.
Jia Y, Yu H, Liang J, Zhang Q, Sun J, Yang H, Yan H, Zhang S, Li Y, Jin Y, Yang M
Nutrients 2024 Apr 23;16(9)
Nutrients 2024 Apr 23;16(9)
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
Zhang Q, Shen X, Yuan X, Huang J, Zhu Y, Zhu T, Zhang T, Wu H, Wu Q, Fan Y, Ni J, Meng L, He A, Shi C, Li H, Hu Q, Wang J, Chang C, Huang F, Li F, Chen M, Liu A, Ye S, Zheng M, Fang H
Nature communications 2024 Apr 13;15(1):3213
Nature communications 2024 Apr 13;15(1):3213
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Zhang H, Zhou P, Xing W, Chen L, Zhou Y, Yang H, Fu K, Liu Z
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856
PeerJ 2023;11:e15856
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Shen Y, Cheng L, Xu M, Wang W, Wan Z, Xiong H, Guo W, Cai M, Xu F
Metabolism: clinical and experimental 2023 Sep;146:155657
Metabolism: clinical and experimental 2023 Sep;146:155657
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Yue C, Li D, Fan S, Tao F, Yu Y, Lu W, Chen Q, Yuan A, Wu J, Zhao G, Dong H, Hu Y
Biomaterials 2023 Oct;301:122291
Biomaterials 2023 Oct;301:122291
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL
Nature communications 2023 Oct 13;14(1):6469
Nature communications 2023 Oct 13;14(1):6469
Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis.
Belgacemi R, Ribeiro Baptista B, Justeau G, Toigo M, Frauenpreis A, Yilmaz R, Der Vartanian A, Cazaunau M, Pangui E, Bergé A, Gratien A, Macias Rodriguez JC, Bellusci S, Derumeaux G, Boczkowski J, Al Alam D, Coll P, Lanone S, Boyer L
American journal of physiology. Lung cellular and molecular physiology 2023 Oct 1;325(4):L447-L459
American journal of physiology. Lung cellular and molecular physiology 2023 Oct 1;325(4):L447-L459
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.
Park DS, Kozaki T, Tiwari SK, Moreira M, Khalilnezhad A, Torta F, Olivié N, Thiam CH, Liani O, Silvin A, Phoo WW, Gao L, Triebl A, Tham WK, Gonçalves L, Kong WT, Raman S, Zhang XM, Dunsmore G, Dutertre CA, Lee S, Ong JM, Balachander A, Khalilnezhad S, Lum J, Duan K, Lim ZM, Tan L, Low I, Utami KH, Yeo XY, Di Tommaso S, Dupuy JW, Varga B, Karadottir RT, Madathummal MC, Bonne I, Malleret B, Binte ZY, Wei Da N, Tan Y, Wong WJ, Zhang J, Chen J, Sobota RM, Howland SW, Ng LG, Saltel F, Castel D, Grill J, Minard V, Albani S, Chan JKY, Thion MS, Jung SY, Wenk MR, Pouladi MA, Pasqualini C, Angeli V, Cexus ONF, Ginhoux F
Nature 2023 Nov;623(7986):397-405
Nature 2023 Nov;623(7986):397-405
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)
Life science alliance 2023 Nov;6(11)
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
Cui D, Wang Z, Dang Q, Wang J, Qin J, Song J, Zhai X, Zhou Y, Zhao L, Lu G, Liu H, Liu G, Liu R, Shao C, Zhang X, Liu Z
Nature communications 2023 Nov 3;14(1):7032
Nature communications 2023 Nov 3;14(1):7032
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Xia Y, Zhang Y, Sun Y, He L
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Wang YN, Yu L, Wang T, Liu S
International journal of biological macromolecules 2023 May 1;236:123998
International journal of biological macromolecules 2023 May 1;236:123998
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM
Acta neuropathologica 2023 Jun;145(6):749-772
Acta neuropathologica 2023 Jun;145(6):749-772
Lipid droplets are a metabolic vulnerability in melanoma.
Lumaquin-Yin D, Montal E, Johns E, Baggiolini A, Huang TH, Ma Y, LaPlante C, Suresh S, Studer L, White RM
Nature communications 2023 Jun 2;14(1):3192
Nature communications 2023 Jun 2;14(1):3192
Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis.
Tan Y, Li C, Zhou J, Deng F, Liu Y
Experimental cell research 2023 Jun 15;427(2):113600
Experimental cell research 2023 Jun 15;427(2):113600
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X
Redox biology 2023 Jul;63:102732
Redox biology 2023 Jul;63:102732
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Wei X, Lin L, Yuan QQ, Wang XY, Zhang Q, Zhang XM, Tang KC, Guo MY, Dong TY, Han W, Huang DK, Qi YL, Zhang M, Zhang HB
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
Zhang T, Feng T, Wu K, Guo J, Nana AL, Yang G, Seeley WW, Hu F
Acta neuropathologica 2023 Jul;146(1):97-119
Acta neuropathologica 2023 Jul;146(1):97-119
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T
bioRxiv : the preprint server for biology 2023 Jul 25;
bioRxiv : the preprint server for biology 2023 Jul 25;
Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.
Montal E, Lumaquin D, Ma Y, Suresh S, White RM
Disease models & mechanisms 2023 Jan 1;16(1)
Disease models & mechanisms 2023 Jan 1;16(1)
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.
Yang X, Zhang Z, Shen X, Xu J, Weng Y, Wang W, Xue J
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1645-1658
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1645-1658
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke.
Hernandez VG, Lechtenberg KJ, Peterson TC, Zhu L, Lucas TA, Bradshaw KP, Owah JO, Dorsey AI, Gentles AJ, Buckwalter MS
Glia 2023 Aug;71(8):1960-1984
Glia 2023 Aug;71(8):1960-1984
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C
Nature neuroscience 2023 Apr;26(4):542-554
Nature neuroscience 2023 Apr;26(4):542-554
Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.
Zheng K, Zhou W, Ji J, Xue Y, Liu Y, Li C, Zhang Z, Lu J, Shi X, Li Y
Journal of ethnopharmacology 2023 Apr 6;305:116081
Journal of ethnopharmacology 2023 Apr 6;305:116081
Salvianolic Acid B Reduces the Inflammation of Fat Grafts by Inhibiting the NF-Kb Signalling Pathway in Macrophages.
Sun JM, Ho CK, Gao Y, Chong CH, Liu YD, Liu YX, Zheng DN, Zhang YF, Yu L
Aesthetic surgery journal 2023 Apr 10;43(5):NP372-NP390
Aesthetic surgery journal 2023 Apr 10;43(5):NP372-NP390
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Gu W, Yang L, Wang X, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
Kidney & blood pressure research 2022;47(8):514-522
Kidney & blood pressure research 2022;47(8):514-522
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.
Zhang Y, Gu Z, Wan J, Lou X, Liu S, Wang Y, Bian Y, Wang F, Li Z, Qin Z
International journal of biological sciences 2022;18(16):6114-6128
International journal of biological sciences 2022;18(16):6114-6128
Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells.
Johnson M, Nowlan S, Sahin G, Barnett DA, Joy AP, Touaibia M, Cuperlovic-Culf M, Zofija Avizonis D, Turcotte S
Frontiers in oncology 2022;12:841054
Frontiers in oncology 2022;12:841054
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.
Zhao C, Li L, Li C, Tang C, Cai J, Liu Y, Yang J, Xi Y, Yang M, Jiang N, Han Y, Liu Y, Luo S, Xiao L, Sun L
Molecular medicine (Cambridge, Mass.) 2022 Sep 23;28(1):117
Molecular medicine (Cambridge, Mass.) 2022 Sep 23;28(1):117
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α.
Liu W, Liu X, Liu Y, Ling T, Chen D, Otkur W, Zhao H, Ma M, Ma K, Dong B, Yang Z, Piao HL, Liang R, Dong C
Experimental cell research 2022 Sep 1;418(1):113244
Experimental cell research 2022 Sep 1;418(1):113244
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY
Journal of lipid research 2022 Oct;63(10):100277
Journal of lipid research 2022 Oct;63(10):100277
Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Tang X, Song F, Zhao W, Zhang Z, Cao Y
Journal of applied toxicology : JAT 2022 Nov;42(11):1822-1831
Journal of applied toxicology : JAT 2022 Nov;42(11):1822-1831
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X
Cell death and differentiation 2022 Nov;29(11):2316-2331
Cell death and differentiation 2022 Nov;29(11):2316-2331
Milk fat globule membrane proteins are involved in controlling the size of milk fat globules during conjugated linoleic acid-induced milk fat depression.
Huang QX, Yang J, Hu M, Lu W, Zhong K, Wang Y, Yang G, Loor JJ, Han L
Journal of dairy science 2022 Nov;105(11):9179-9190
Journal of dairy science 2022 Nov;105(11):9179-9190
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Yang Y, Li X, Liu Z, Ruan X, Wang H, Zhang Q, Cao L, Song L, Chen Y, Sun Y
Nutrients 2022 Nov 20;14(22)
Nutrients 2022 Nov 20;14(22)
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Liu J, Li D, Dun Y, Li H, Ripley-Gonzalez JW, Zhang J, Qiu L, You B, Liu S
Life sciences 2022 Nov 1;308:120949
Life sciences 2022 Nov 1;308:120949
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention.
Liu S, Da J, Yu J, Dong R, Yuan J, Yu F, Zha Y
Journal of physiology and biochemistry 2022 May;78(2):389-399
Journal of physiology and biochemistry 2022 May;78(2):389-399
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, Peng C, Lin LG
Acta pharmacologica Sinica 2022 May;43(5):1285-1298
Acta pharmacologica Sinica 2022 May;43(5):1285-1298
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Gu W, Wang X, Zhao H, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
European journal of pharmacology 2022 Mar 5;918:174776
European journal of pharmacology 2022 Mar 5;918:174776
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Chen L, You Q, Liu M, Li S, Wu Z, Hu J, Ma Y, Xia L, Zhou Y, Xu N, Zhang S
eLife 2022 Mar 24;11
eLife 2022 Mar 24;11
Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.
Zhang P, Tian L, Bao J, Li S, Li A, Wen Y, Wang J, Jie Y
Investigative ophthalmology & visual science 2022 Mar 2;63(3):29
Investigative ophthalmology & visual science 2022 Mar 2;63(3):29
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
Ricciardi S, Guarino AM, Giaquinto L, Polishchuk EV, Santoro M, Di Tullio G, Wilson C, Panariello F, Soares VC, Dias SSG, Santos JC, Souza TML, Fusco G, Viscardi M, Brandi S, Bozza PT, Polishchuk RS, Venditti R, De Matteis MA
Nature 2022 Jun;606(7915):761-768
Nature 2022 Jun;606(7915):761-768
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Lipid droplet dynamics in healthy and pyometra-affected canine endometrium.
Leitner N, Hlavaty J, Heider S, Ertl R, Gabriel C, Walter I
BMC veterinary research 2022 Jun 11;18(1):221
BMC veterinary research 2022 Jun 11;18(1):221
Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.
Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A
Molecular and cellular endocrinology 2022 Jan 1;539:111472
Molecular and cellular endocrinology 2022 Jan 1;539:111472
Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma.
Hao L, Guo Y, Peng Q, Zhang Z, Ji J, Liu Y, Xue Y, Li C, Zheng K, Shi X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153913
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153913
Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet.
Tao T, Kobelski MM, Saini V, Demay MB
Endocrinology 2022 Feb 1;163(2)
Endocrinology 2022 Feb 1;163(2)
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Zhou B, Zheng Y, Li X, Dong H, Yu J, Zou Y, Zhu M, Yu Y, Fang X, Zhou M, Zhang W, Yuan Y, Wang Z, Deng J, Hong D
Molecular neurobiology 2022 Dec;59(12):7265-7277
Molecular neurobiology 2022 Dec;59(12):7265-7277
Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models.
Leitner N, Hlavatý J, Ertl R, Gabner S, Fuchs-Baumgartinger A, Walter I
Veterinary research communications 2022 Dec;46(4):1175-1193
Veterinary research communications 2022 Dec;46(4):1175-1193
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z
Journal of molecular cell biology 2022 Dec 26;14(8)
Journal of molecular cell biology 2022 Dec 26;14(8)
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
Jin Y, Tan Y, Zhao P, Guo Y, Chen S, Wu J, Ren Z
Communications biology 2022 Apr 6;5(1):326
Communications biology 2022 Apr 6;5(1):326
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Inflammasome Activation and Pyroptosis via a Lipid-regulated SIRT1-p53-ASC Axis in Macrophages From Male Mice and Humans.
Huang Y, Yong P, Dickey D, Vora SM, Wu H, Bernlohr DA
Endocrinology 2022 Apr 1;163(4)
Endocrinology 2022 Apr 1;163(4)
Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules.
Li W, Duan A, Xing Y, Xu L, Yang J
Frontiers in cell and developmental biology 2021;9:690079
Frontiers in cell and developmental biology 2021;9:690079
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Song G, Qi W, Wang Y, Pang S, Li Y
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans.
Churin Y, Irungbam K, Imiela CS, Schwarz D, Mollenkopf HJ, Drebber U, Odenthal M, Pak O, Huber M, Glebe D, Roderfeld M, Roeb E
Cellular and molecular gastroenterology and hepatology 2021;12(2):383-394
Cellular and molecular gastroenterology and hepatology 2021;12(2):383-394
Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease.
Wang R, Wang Z, Sun R, Fu R, Sun Y, Zhu M, Geng Y, Gao D, Tian X, Zhao Y, Yao J
Frontiers in pharmacology 2021;12:775528
Frontiers in pharmacology 2021;12:775528
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Sun JM, Ho CK, Gao Y, Chong CH, Zheng DN, Zhang YF, Yu L
Stem cell research & therapy 2021 Sep 17;12(1):507
Stem cell research & therapy 2021 Sep 17;12(1):507
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
Human cell 2021 May;34(3):785-799
Human cell 2021 May;34(3):785-799
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yang L, Li S, Mo C, Zhou B, Fan S, Shi F, Wei X, Zhao Q, Yang G, Li S, Mou C
Poultry science 2021 Mar;100(3):100892
Poultry science 2021 Mar;100(3):100892
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z
Pharmacological research 2021 Jul;169:105639
Pharmacological research 2021 Jul;169:105639
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM, Kedishvili NY
The Journal of biological chemistry 2021 Jan-Jun;296:100323
The Journal of biological chemistry 2021 Jan-Jun;296:100323
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D
Nature metabolism 2021 Feb;3(2):244-257
Nature metabolism 2021 Feb;3(2):244-257
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Jiang YH, Zhang P, Tao Y, Liu Y, Cao G, Zhou L, Yang CH
Journal of ethnopharmacology 2021 Feb 10;266:113453
Journal of ethnopharmacology 2021 Feb 10;266:113453
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Pan S, Zhang L, Liu Z, Xing H
Journal of animal science 2021 Dec 1;99(12)
Journal of animal science 2021 Dec 1;99(12)
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
Bao W, Cao L, Wei H, Zhu D, Zhou G, Wang J, Guo S
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Zhang Q, Zhang P, Li B, Dang H, Jiang J, Meng L, Zhang H, Zhang Y, Wang X, Li Q, Wang Y, Liu C, Li F
Journal of Cancer 2020;11(14):4081-4090
Journal of Cancer 2020;11(14):4081-4090
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Scales SJ, Gupta N, De Mazière AM, Posthuma G, Chiu CP, Pierce AA, Hötzel K, Tao J, Foreman O, Koukos G, Oltrabella F, Klumperman J, Lin W, Peterson AS
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Yao D, Xia S, Jin C, Zhao W, Lan W, Liu Z, Xiu Y
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Yang T, Chen J, Gao L, Huang Y, Liao G, Cao Y
Toxicology letters 2020 Oct 10;332:65-73
Toxicology letters 2020 Oct 10;332:65-73
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Irungbam K, Roderfeld M, Glimm H, Hempel F, Schneider F, Hehr L, Glebe D, Churin Y, Morlock G, Yüce I, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Irungbam K, Churin Y, Matono T, Weglage J, Ocker M, Glebe D, Hardt M, Koeppel A, Roderfeld M, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Song YF, Hogstrand C, Ling SC, Chen GH, Luo Z
The Journal of nutritional biochemistry 2020 Jun;80:108364
The Journal of nutritional biochemistry 2020 Jun;80:108364
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4
Molecular cell 2020 Jul 2;79(1):30-42.e4
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE
Journal of lipid research 2020 Jan;61(1):33-44
Journal of lipid research 2020 Jan;61(1):33-44
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Yang Y, Fu M, Li MD, Zhang K, Zhang B, Wang S, Liu Y, Ni W, Ong Q, Mi J, Yang X
Nature communications 2020 Jan 10;11(1):181
Nature communications 2020 Jan 10;11(1):181
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
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Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Luo Y, Peng J, Huang C, Cao Y
Ecotoxicology and environmental safety 2020 Aug;199:110714
Ecotoxicology and environmental safety 2020 Aug;199:110714
A critical role of VMP1 in lipoprotein secretion.
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eLife 2019 Sep 17;8
eLife 2019 Sep 17;8
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, Schmidt F, Friedrich M, Keye J, Wan J, Qin Y, Kühl AA, Qin Z, Siegmund B, Glauben R
EMBO molecular medicine 2019 Nov 7;11(11):e10698
EMBO molecular medicine 2019 Nov 7;11(11):e10698
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Cruz ALS, Carrossini N, Teixeira LK, Ribeiro-Pinto LF, Bozza PT, Viola JPB
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Keenan SN, Meex RC, Lo JCY, Ryan A, Nie S, Montgomery MK, Watt MJ
Diabetes 2019 Mar;68(3):543-555
Diabetes 2019 Mar;68(3):543-555
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
Souza-Moreira L, Soares VC, Dias SDSG, Bozza PT
Scientific reports 2019 Dec 30;9(1):20304
Scientific reports 2019 Dec 30;9(1):20304
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
Li D, Zhao YG, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D, Zhang H
Cell reports 2019 Apr 9;27(2):343-358.e5
Cell reports 2019 Apr 9;27(2):343-358.e5
TMEM41B is a novel regulator of autophagy and lipid mobilization.
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EMBO reports 2018 Sep;19(9)
EMBO reports 2018 Sep;19(9)
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Jin Y, Tan Y, Chen L, Liu Y, Ren Z
International journal of molecular sciences 2018 Nov 2;19(11)
International journal of molecular sciences 2018 Nov 2;19(11)
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
Montgomery MK, Mokhtar R, Bayliss J, Parkington HC, Suturin VM, Bruce CR, Watt MJ
Diabetes 2018 Apr;67(4):594-606
Diabetes 2018 Apr;67(4):594-606
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Kai M, Miyoshi M, Fujiwara M, Nishiyama Y, Inoue T, Maeshige N, Hamada Y, Usami M
The Journal of surgical research 2017 May 15;212:22-32
The Journal of surgical research 2017 May 15;212:22-32
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N
FEBS letters 2017 Dec;591(23):3819-3830
FEBS letters 2017 Dec;591(23):3819-3830
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Graffmann N, Ring S, Kawala MA, Wruck W, Ncube A, Trompeter HI, Adjaye J
Stem cells and development 2016 Aug 1;25(15):1119-33
Stem cells and development 2016 Aug 1;25(15):1119-33
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Mori E, Fujikura J, Noguchi M, Nakao K, Matsubara M, Sone M, Taura D, Kusakabe T, Ebihara K, Tanaka T, Hosoda K, Takahashi K, Asaka I, Inagaki N, Nakao K
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ADRP/Perilipin 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ADRP/Perilipin 2. This antibody recognizes human,mouse,rat antigen. The ADRP/Perilipin 2 antibody has been validated for the following applications: ELISA, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15294-1-AP(ADRP antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
