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- Antibody Data
- Antigen structure
- References [46]
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- Validations
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 15294-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ADRP/Perilipin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ADRP/Perilipin 2 antibody (Cat. #15294-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
A critical role of VMP1 in lipoprotein secretion.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A
Molecular and cellular endocrinology 2022 Jan 1;539:111472
Molecular and cellular endocrinology 2022 Jan 1;539:111472
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Song G, Qi W, Wang Y, Pang S, Li Y
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Sun JM, Ho CK, Gao Y, Chong CH, Zheng DN, Zhang YF, Yu L
Stem cell research & therapy 2021 Sep 17;12(1):507
Stem cell research & therapy 2021 Sep 17;12(1):507
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
Human cell 2021 May;34(3):785-799
Human cell 2021 May;34(3):785-799
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yang L, Li S, Mo C, Zhou B, Fan S, Shi F, Wei X, Zhao Q, Yang G, Li S, Mou C
Poultry science 2021 Mar;100(3):100892
Poultry science 2021 Mar;100(3):100892
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z
Pharmacological research 2021 Jul;169:105639
Pharmacological research 2021 Jul;169:105639
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM, Kedishvili NY
The Journal of biological chemistry 2021 Jan-Jun;296:100323
The Journal of biological chemistry 2021 Jan-Jun;296:100323
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D
Nature metabolism 2021 Feb;3(2):244-257
Nature metabolism 2021 Feb;3(2):244-257
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Jiang YH, Zhang P, Tao Y, Liu Y, Cao G, Zhou L, Yang CH
Journal of ethnopharmacology 2021 Feb 10;266:113453
Journal of ethnopharmacology 2021 Feb 10;266:113453
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Pan S, Zhang L, Liu Z, Xing H
Journal of animal science 2021 Dec 1;99(12)
Journal of animal science 2021 Dec 1;99(12)
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, Peng C, Lin LG
Acta pharmacologica Sinica 2021 Aug 20;
Acta pharmacologica Sinica 2021 Aug 20;
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2021 Aug 12;:1-17
Autophagy 2021 Aug 12;:1-17
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
Bao W, Cao L, Wei H, Zhu D, Zhou G, Wang J, Guo S
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Zhang Q, Zhang P, Li B, Dang H, Jiang J, Meng L, Zhang H, Zhang Y, Wang X, Li Q, Wang Y, Liu C, Li F
Journal of Cancer 2020;11(14):4081-4090
Journal of Cancer 2020;11(14):4081-4090
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Scales SJ, Gupta N, De Mazière AM, Posthuma G, Chiu CP, Pierce AA, Hötzel K, Tao J, Foreman O, Koukos G, Oltrabella F, Klumperman J, Lin W, Peterson AS
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Yao D, Xia S, Jin C, Zhao W, Lan W, Liu Z, Xiu Y
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Yang T, Chen J, Gao L, Huang Y, Liao G, Cao Y
Toxicology letters 2020 Oct 10;332:65-73
Toxicology letters 2020 Oct 10;332:65-73
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Irungbam K, Roderfeld M, Glimm H, Hempel F, Schneider F, Hehr L, Glebe D, Churin Y, Morlock G, Yüce I, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Irungbam K, Churin Y, Matono T, Weglage J, Ocker M, Glebe D, Hardt M, Koeppel A, Roderfeld M, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Song YF, Hogstrand C, Ling SC, Chen GH, Luo Z
The Journal of nutritional biochemistry 2020 Jun;80:108364
The Journal of nutritional biochemistry 2020 Jun;80:108364
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4
Molecular cell 2020 Jul 2;79(1):30-42.e4
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE
Journal of lipid research 2020 Jan;61(1):33-44
Journal of lipid research 2020 Jan;61(1):33-44
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Yang Y, Fu M, Li MD, Zhang K, Zhang B, Wang S, Liu Y, Ni W, Ong Q, Mi J, Yang X
Nature communications 2020 Jan 10;11(1):181
Nature communications 2020 Jan 10;11(1):181
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Luo Y, Peng J, Huang C, Cao Y
Ecotoxicology and environmental safety 2020 Aug;199:110714
Ecotoxicology and environmental safety 2020 Aug;199:110714
A critical role of VMP1 in lipoprotein secretion.
Morishita H, Zhao YG, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
eLife 2019 Sep 17;8
eLife 2019 Sep 17;8
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, Schmidt F, Friedrich M, Keye J, Wan J, Qin Y, Kühl AA, Qin Z, Siegmund B, Glauben R
EMBO molecular medicine 2019 Nov 7;11(11):e10698
EMBO molecular medicine 2019 Nov 7;11(11):e10698
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Cruz ALS, Carrossini N, Teixeira LK, Ribeiro-Pinto LF, Bozza PT, Viola JPB
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Keenan SN, Meex RC, Lo JCY, Ryan A, Nie S, Montgomery MK, Watt MJ
Diabetes 2019 Mar;68(3):543-555
Diabetes 2019 Mar;68(3):543-555
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
Souza-Moreira L, Soares VC, Dias SDSG, Bozza PT
Scientific reports 2019 Dec 30;9(1):20304
Scientific reports 2019 Dec 30;9(1):20304
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
Li D, Zhao YG, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D, Zhang H
Cell reports 2019 Apr 9;27(2):343-358.e5
Cell reports 2019 Apr 9;27(2):343-358.e5
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B
EMBO reports 2018 Sep;19(9)
EMBO reports 2018 Sep;19(9)
Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.
Jin Y, Tan Y, Chen L, Liu Y, Ren Z
International journal of molecular sciences 2018 Nov 2;19(11)
International journal of molecular sciences 2018 Nov 2;19(11)
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
Montgomery MK, Mokhtar R, Bayliss J, Parkington HC, Suturin VM, Bruce CR, Watt MJ
Diabetes 2018 Apr;67(4):594-606
Diabetes 2018 Apr;67(4):594-606
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Kai M, Miyoshi M, Fujiwara M, Nishiyama Y, Inoue T, Maeshige N, Hamada Y, Usami M
The Journal of surgical research 2017 May 15;212:22-32
The Journal of surgical research 2017 May 15;212:22-32
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N
FEBS letters 2017 Dec;591(23):3819-3830
FEBS letters 2017 Dec;591(23):3819-3830
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Graffmann N, Ring S, Kawala MA, Wruck W, Ncube A, Trompeter HI, Adjaye J
Stem cells and development 2016 Aug 1;25(15):1119-33
Stem cells and development 2016 Aug 1;25(15):1119-33
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Mori E, Fujikura J, Noguchi M, Nakao K, Matsubara M, Sone M, Taura D, Kusakabe T, Ebihara K, Tanaka T, Hosoda K, Takahashi K, Asaka I, Inagaki N, Nakao K
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ADRP/Perilipin 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ADRP/Perilipin 2. This antibody recognizes human,mouse,rat antigen. The ADRP/Perilipin 2 antibody has been validated for the following applications: ELISA, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15294-1-AP(ADRP antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
