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- Antigen structure
- References [121]
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- Immunohistochemistry [1]
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- Product number
- 15294-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ADRP/Perilipin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ADRP/Perilipin 2 antibody (Cat. #15294-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice.
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis.
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway.
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis.
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Increased FGF-21 Improves Ectopic Lipid Deposition in the Liver and Skeletal Muscle.
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis.
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Lipid droplets are a metabolic vulnerability in melanoma.
Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis.
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.
Salvianolic Acid B Reduces the Inflammation of Fat Grafts by Inhibiting the NF-Kb Signalling Pathway in Macrophages.
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.
Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells.
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α.
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Milk fat globule membrane proteins are involved in controlling the size of milk fat globules during conjugated linoleic acid-induced milk fat depression.
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention.
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Lipid droplet dynamics in healthy and pyometra-affected canine endometrium.
Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.
Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma.
Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet.
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Inflammasome Activation and Pyroptosis via a Lipid-regulated SIRT1-p53-ASC Axis in Macrophages From Male Mice and Humans.
Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules.
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease.
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
A critical role of VMP1 in lipoprotein secretion.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Takahashi N, Ichii O, Hiraishi M, Namba T, Otani Y, Nakamura T, Kon Y
PloS one 2024;19(4):e0302041
PloS one 2024;19(4):e0302041
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis.
Hauck AK, Mehmood R, Carpenter BJ, Frankfurter MT, Tackenberg MC, Inoue SI, Krieg MK, Cassim Bawa FN, Midha MK, Zundell DM, Batmanov K, Lazar MA
Nature metabolism 2024 May;6(5):825-836
Nature metabolism 2024 May;6(5):825-836
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.
Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J
Cancer cell 2024 May 13;42(5):869-884.e9
Cancer cell 2024 May 13;42(5):869-884.e9
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769
Metabolism: clinical and experimental 2024 Mar;152:155769
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Qu H, Liu X, Zhu J, Xiong X, Li L, He Q, Wang Y, Yang G, Zhang L, Yang Q, Luo G, Zheng Y, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Xiong Q, Sun H, Wang Y, Xu Q, Zhang Y, Xu M, Zhao Z, Li P, Wu C
Lipids in health and disease 2024 Mar 28;23(1):91
Lipids in health and disease 2024 Mar 28;23(1):91
Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
Pei J, Zou D, Li L, Kang L, Sun M, Li X, Chen Q, Chen D, Qu B, Gao X, Lin Z
The Journal of biological chemistry 2024 Jun;300(6):107319
The Journal of biological chemistry 2024 Jun;300(6):107319
PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway.
Yang K, Yu X, Guo Z, Fang Z, Zhang H, Zhang W, Liu C, Ji Y, Dong Z, Gu Q, Yao J, Liu C
Life sciences 2024 Jul 15;349:122714
Life sciences 2024 Jul 15;349:122714
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Tzur Y, Winek K, Madrer N, Dubnov S, Bennett ER, Greenberg DS, Hanin G, Gammal A, Tam J, Arkin IT, Paldor I, Soreq H
Molecular metabolism 2024 Jan;79:101856
Molecular metabolism 2024 Jan;79:101856
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.
Ghosh S, Bandyopadhyay S, Smith DM, Adak S, Semenkovich CF, Nagy L, Wolfgang MJ, O'Connor TJ
PLoS pathogens 2024 Feb;20(2):e1011996
PLoS pathogens 2024 Feb;20(2):e1011996
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.
Guan X, Wu J, Geng J, Ji D, Wei D, Ling Y, Zhang Y, Jiang G, Pang T, Huang Z
Translational stroke research 2024 Feb;15(1):195-218
Translational stroke research 2024 Feb;15(1):195-218
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Liu J, Xu D, Yan J, Wang B, Zhang L, Liu X, Zhang H, Yan G, Yang J, Zeng Q, Wang X
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson PK, Yip O, Dong W, Rawat E, West E, Schlachetzki JCM, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T
Nature 2024 Apr;628(8006):154-161
Nature 2024 Apr;628(8006):154-161
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18.
Li GL, Han YQ, Su BQ, Yu HS, Zhang S, Yang GY, Wang J, Liu F, Ming SL, Chu BB
PLoS pathogens 2024 Apr;20(4):e1012123
PLoS pathogens 2024 Apr;20(4):e1012123
GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis.
Shen R, Qin S, Lv Y, Liu D, Ke Q, Shi C, Jiang L, Yang J, Zhou Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167060
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167060
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Zhong D, Chen J, Qiao R, Song C, Hao C, Zou Y, Bai M, Su W, Yang B, Sun D, Jia Z, Sun Y
Cell reports 2024 Apr 23;43(4):114075
Cell reports 2024 Apr 23;43(4):114075
Increased FGF-21 Improves Ectopic Lipid Deposition in the Liver and Skeletal Muscle.
Jia Y, Yu H, Liang J, Zhang Q, Sun J, Yang H, Yan H, Zhang S, Li Y, Jin Y, Yang M
Nutrients 2024 Apr 23;16(9)
Nutrients 2024 Apr 23;16(9)
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
Zhang Q, Shen X, Yuan X, Huang J, Zhu Y, Zhu T, Zhang T, Wu H, Wu Q, Fan Y, Ni J, Meng L, He A, Shi C, Li H, Hu Q, Wang J, Chang C, Huang F, Li F, Chen M, Liu A, Ye S, Zheng M, Fang H
Nature communications 2024 Apr 13;15(1):3213
Nature communications 2024 Apr 13;15(1):3213
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Zhang H, Zhou P, Xing W, Chen L, Zhou Y, Yang H, Fu K, Liu Z
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856
PeerJ 2023;11:e15856
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Shen Y, Cheng L, Xu M, Wang W, Wan Z, Xiong H, Guo W, Cai M, Xu F
Metabolism: clinical and experimental 2023 Sep;146:155657
Metabolism: clinical and experimental 2023 Sep;146:155657
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Yue C, Li D, Fan S, Tao F, Yu Y, Lu W, Chen Q, Yuan A, Wu J, Zhao G, Dong H, Hu Y
Biomaterials 2023 Oct;301:122291
Biomaterials 2023 Oct;301:122291
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL
Nature communications 2023 Oct 13;14(1):6469
Nature communications 2023 Oct 13;14(1):6469
Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis.
Belgacemi R, Ribeiro Baptista B, Justeau G, Toigo M, Frauenpreis A, Yilmaz R, Der Vartanian A, Cazaunau M, Pangui E, Bergé A, Gratien A, Macias Rodriguez JC, Bellusci S, Derumeaux G, Boczkowski J, Al Alam D, Coll P, Lanone S, Boyer L
American journal of physiology. Lung cellular and molecular physiology 2023 Oct 1;325(4):L447-L459
American journal of physiology. Lung cellular and molecular physiology 2023 Oct 1;325(4):L447-L459
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.
Park DS, Kozaki T, Tiwari SK, Moreira M, Khalilnezhad A, Torta F, Olivié N, Thiam CH, Liani O, Silvin A, Phoo WW, Gao L, Triebl A, Tham WK, Gonçalves L, Kong WT, Raman S, Zhang XM, Dunsmore G, Dutertre CA, Lee S, Ong JM, Balachander A, Khalilnezhad S, Lum J, Duan K, Lim ZM, Tan L, Low I, Utami KH, Yeo XY, Di Tommaso S, Dupuy JW, Varga B, Karadottir RT, Madathummal MC, Bonne I, Malleret B, Binte ZY, Wei Da N, Tan Y, Wong WJ, Zhang J, Chen J, Sobota RM, Howland SW, Ng LG, Saltel F, Castel D, Grill J, Minard V, Albani S, Chan JKY, Thion MS, Jung SY, Wenk MR, Pouladi MA, Pasqualini C, Angeli V, Cexus ONF, Ginhoux F
Nature 2023 Nov;623(7986):397-405
Nature 2023 Nov;623(7986):397-405
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)
Life science alliance 2023 Nov;6(11)
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
Cui D, Wang Z, Dang Q, Wang J, Qin J, Song J, Zhai X, Zhou Y, Zhao L, Lu G, Liu H, Liu G, Liu R, Shao C, Zhang X, Liu Z
Nature communications 2023 Nov 3;14(1):7032
Nature communications 2023 Nov 3;14(1):7032
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Xia Y, Zhang Y, Sun Y, He L
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Wang YN, Yu L, Wang T, Liu S
International journal of biological macromolecules 2023 May 1;236:123998
International journal of biological macromolecules 2023 May 1;236:123998
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM
Acta neuropathologica 2023 Jun;145(6):749-772
Acta neuropathologica 2023 Jun;145(6):749-772
Lipid droplets are a metabolic vulnerability in melanoma.
Lumaquin-Yin D, Montal E, Johns E, Baggiolini A, Huang TH, Ma Y, LaPlante C, Suresh S, Studer L, White RM
Nature communications 2023 Jun 2;14(1):3192
Nature communications 2023 Jun 2;14(1):3192
Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis.
Tan Y, Li C, Zhou J, Deng F, Liu Y
Experimental cell research 2023 Jun 15;427(2):113600
Experimental cell research 2023 Jun 15;427(2):113600
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Wei X, Lin L, Yuan QQ, Wang XY, Zhang Q, Zhang XM, Tang KC, Guo MY, Dong TY, Han W, Huang DK, Qi YL, Zhang M, Zhang HB
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
Zhang T, Feng T, Wu K, Guo J, Nana AL, Yang G, Seeley WW, Hu F
Acta neuropathologica 2023 Jul;146(1):97-119
Acta neuropathologica 2023 Jul;146(1):97-119
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T
bioRxiv : the preprint server for biology 2023 Jul 25;
bioRxiv : the preprint server for biology 2023 Jul 25;
Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.
Montal E, Lumaquin D, Ma Y, Suresh S, White RM
Disease models & mechanisms 2023 Jan 1;16(1)
Disease models & mechanisms 2023 Jan 1;16(1)
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.
Yang X, Zhang Z, Shen X, Xu J, Weng Y, Wang W, Xue J
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1645-1658
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1645-1658
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C
Nature neuroscience 2023 Apr;26(4):542-554
Nature neuroscience 2023 Apr;26(4):542-554
Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.
Zheng K, Zhou W, Ji J, Xue Y, Liu Y, Li C, Zhang Z, Lu J, Shi X, Li Y
Journal of ethnopharmacology 2023 Apr 6;305:116081
Journal of ethnopharmacology 2023 Apr 6;305:116081
Salvianolic Acid B Reduces the Inflammation of Fat Grafts by Inhibiting the NF-Kb Signalling Pathway in Macrophages.
Sun JM, Ho CK, Gao Y, Chong CH, Liu YD, Liu YX, Zheng DN, Zhang YF, Yu L
Aesthetic surgery journal 2023 Apr 10;43(5):NP372-NP390
Aesthetic surgery journal 2023 Apr 10;43(5):NP372-NP390
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Gu W, Yang L, Wang X, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
Kidney & blood pressure research 2022;47(8):514-522
Kidney & blood pressure research 2022;47(8):514-522
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.
Zhang Y, Gu Z, Wan J, Lou X, Liu S, Wang Y, Bian Y, Wang F, Li Z, Qin Z
International journal of biological sciences 2022;18(16):6114-6128
International journal of biological sciences 2022;18(16):6114-6128
Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells.
Johnson M, Nowlan S, Sahin G, Barnett DA, Joy AP, Touaibia M, Cuperlovic-Culf M, Zofija Avizonis D, Turcotte S
Frontiers in oncology 2022;12:841054
Frontiers in oncology 2022;12:841054
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.
Zhao C, Li L, Li C, Tang C, Cai J, Liu Y, Yang J, Xi Y, Yang M, Jiang N, Han Y, Liu Y, Luo S, Xiao L, Sun L
Molecular medicine (Cambridge, Mass.) 2022 Sep 23;28(1):117
Molecular medicine (Cambridge, Mass.) 2022 Sep 23;28(1):117
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α.
Liu W, Liu X, Liu Y, Ling T, Chen D, Otkur W, Zhao H, Ma M, Ma K, Dong B, Yang Z, Piao HL, Liang R, Dong C
Experimental cell research 2022 Sep 1;418(1):113244
Experimental cell research 2022 Sep 1;418(1):113244
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY
Journal of lipid research 2022 Oct;63(10):100277
Journal of lipid research 2022 Oct;63(10):100277
Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Tang X, Song F, Zhao W, Zhang Z, Cao Y
Journal of applied toxicology : JAT 2022 Nov;42(11):1822-1831
Journal of applied toxicology : JAT 2022 Nov;42(11):1822-1831
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X
Cell death and differentiation 2022 Nov;29(11):2316-2331
Cell death and differentiation 2022 Nov;29(11):2316-2331
Milk fat globule membrane proteins are involved in controlling the size of milk fat globules during conjugated linoleic acid-induced milk fat depression.
Huang QX, Yang J, Hu M, Lu W, Zhong K, Wang Y, Yang G, Loor JJ, Han L
Journal of dairy science 2022 Nov;105(11):9179-9190
Journal of dairy science 2022 Nov;105(11):9179-9190
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Yang Y, Li X, Liu Z, Ruan X, Wang H, Zhang Q, Cao L, Song L, Chen Y, Sun Y
Nutrients 2022 Nov 20;14(22)
Nutrients 2022 Nov 20;14(22)
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Liu J, Li D, Dun Y, Li H, Ripley-Gonzalez JW, Zhang J, Qiu L, You B, Liu S
Life sciences 2022 Nov 1;308:120949
Life sciences 2022 Nov 1;308:120949
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention.
Liu S, Da J, Yu J, Dong R, Yuan J, Yu F, Zha Y
Journal of physiology and biochemistry 2022 May;78(2):389-399
Journal of physiology and biochemistry 2022 May;78(2):389-399
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3.
Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, Peng C, Lin LG
Acta pharmacologica Sinica 2022 May;43(5):1285-1298
Acta pharmacologica Sinica 2022 May;43(5):1285-1298
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Gu W, Wang X, Zhao H, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
European journal of pharmacology 2022 Mar 5;918:174776
European journal of pharmacology 2022 Mar 5;918:174776
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Chen L, You Q, Liu M, Li S, Wu Z, Hu J, Ma Y, Xia L, Zhou Y, Xu N, Zhang S
eLife 2022 Mar 24;11
eLife 2022 Mar 24;11
Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.
Zhang P, Tian L, Bao J, Li S, Li A, Wen Y, Wang J, Jie Y
Investigative ophthalmology & visual science 2022 Mar 2;63(3):29
Investigative ophthalmology & visual science 2022 Mar 2;63(3):29
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
Ricciardi S, Guarino AM, Giaquinto L, Polishchuk EV, Santoro M, Di Tullio G, Wilson C, Panariello F, Soares VC, Dias SSG, Santos JC, Souza TML, Fusco G, Viscardi M, Brandi S, Bozza PT, Polishchuk RS, Venditti R, De Matteis MA
Nature 2022 Jun;606(7915):761-768
Nature 2022 Jun;606(7915):761-768
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Lipid droplet dynamics in healthy and pyometra-affected canine endometrium.
Leitner N, Hlavaty J, Heider S, Ertl R, Gabriel C, Walter I
BMC veterinary research 2022 Jun 11;18(1):221
BMC veterinary research 2022 Jun 11;18(1):221
Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats.
Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A
Molecular and cellular endocrinology 2022 Jan 1;539:111472
Molecular and cellular endocrinology 2022 Jan 1;539:111472
Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma.
Hao L, Guo Y, Peng Q, Zhang Z, Ji J, Liu Y, Xue Y, Li C, Zheng K, Shi X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153913
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153913
Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet.
Tao T, Kobelski MM, Saini V, Demay MB
Endocrinology 2022 Feb 1;163(2)
Endocrinology 2022 Feb 1;163(2)
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Zhou B, Zheng Y, Li X, Dong H, Yu J, Zou Y, Zhu M, Yu Y, Fang X, Zhou M, Zhang W, Yuan Y, Wang Z, Deng J, Hong D
Molecular neurobiology 2022 Dec;59(12):7265-7277
Molecular neurobiology 2022 Dec;59(12):7265-7277
Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models.
Leitner N, Hlavatý J, Ertl R, Gabner S, Fuchs-Baumgartinger A, Walter I
Veterinary research communications 2022 Dec;46(4):1175-1193
Veterinary research communications 2022 Dec;46(4):1175-1193
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z
Journal of molecular cell biology 2022 Dec 26;14(8)
Journal of molecular cell biology 2022 Dec 26;14(8)
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
Jin Y, Tan Y, Zhao P, Guo Y, Chen S, Wu J, Ren Z
Communications biology 2022 Apr 6;5(1):326
Communications biology 2022 Apr 6;5(1):326
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Inflammasome Activation and Pyroptosis via a Lipid-regulated SIRT1-p53-ASC Axis in Macrophages From Male Mice and Humans.
Huang Y, Yong P, Dickey D, Vora SM, Wu H, Bernlohr DA
Endocrinology 2022 Apr 1;163(4)
Endocrinology 2022 Apr 1;163(4)
Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules.
Li W, Duan A, Xing Y, Xu L, Yang J
Frontiers in cell and developmental biology 2021;9:690079
Frontiers in cell and developmental biology 2021;9:690079
The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.
Song G, Qi W, Wang Y, Pang S, Li Y
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease.
Wang R, Wang Z, Sun R, Fu R, Sun Y, Zhu M, Geng Y, Gao D, Tian X, Zhao Y, Yao J
Frontiers in pharmacology 2021;12:775528
Frontiers in pharmacology 2021;12:775528
Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis.
Sun JM, Ho CK, Gao Y, Chong CH, Zheng DN, Zhang YF, Yu L
Stem cell research & therapy 2021 Sep 17;12(1):507
Stem cell research & therapy 2021 Sep 17;12(1):507
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
Human cell 2021 May;34(3):785-799
Human cell 2021 May;34(3):785-799
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Yang L, Li S, Mo C, Zhou B, Fan S, Shi F, Wei X, Zhao Q, Yang G, Li S, Mou C
Poultry science 2021 Mar;100(3):100892
Poultry science 2021 Mar;100(3):100892
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z
Pharmacological research 2021 Jul;169:105639
Pharmacological research 2021 Jul;169:105639
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM, Kedishvili NY
The Journal of biological chemistry 2021 Jan-Jun;296:100323
The Journal of biological chemistry 2021 Jan-Jun;296:100323
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D
Nature metabolism 2021 Feb;3(2):244-257
Nature metabolism 2021 Feb;3(2):244-257
Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.
Jiang YH, Zhang P, Tao Y, Liu Y, Cao G, Zhou L, Yang CH
Journal of ethnopharmacology 2021 Feb 10;266:113453
Journal of ethnopharmacology 2021 Feb 10;266:113453
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Pan S, Zhang L, Liu Z, Xing H
Journal of animal science 2021 Dec 1;99(12)
Journal of animal science 2021 Dec 1;99(12)
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting.
Bao W, Cao L, Wei H, Zhu D, Zhou G, Wang J, Guo S
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
Materials science & engineering. C, Materials for biological applications 2021 Apr;123:111973
The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.
Zhang Q, Zhang P, Li B, Dang H, Jiang J, Meng L, Zhang H, Zhang Y, Wang X, Li Q, Wang Y, Liu C, Li F
Journal of Cancer 2020;11(14):4081-4090
Journal of Cancer 2020;11(14):4081-4090
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Scales SJ, Gupta N, De Mazière AM, Posthuma G, Chiu CP, Pierce AA, Hötzel K, Tao J, Foreman O, Koukos G, Oltrabella F, Klumperman J, Lin W, Peterson AS
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2044-2064
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Yao D, Xia S, Jin C, Zhao W, Lan W, Liu Z, Xiu Y
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Yang T, Chen J, Gao L, Huang Y, Liao G, Cao Y
Toxicology letters 2020 Oct 10;332:65-73
Toxicology letters 2020 Oct 10;332:65-73
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.
Irungbam K, Roderfeld M, Glimm H, Hempel F, Schneider F, Hehr L, Glebe D, Churin Y, Morlock G, Yüce I, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1411-1424
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2.
Irungbam K, Churin Y, Matono T, Weglage J, Ocker M, Glebe D, Hardt M, Koeppel A, Roderfeld M, Roeb E
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Laboratory investigation; a journal of technical methods and pathology 2020 Mar;100(3):454-465
Creb-Pgc1α pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish.
Song YF, Hogstrand C, Ling SC, Chen GH, Luo Z
The Journal of nutritional biochemistry 2020 Jun;80:108364
The Journal of nutritional biochemistry 2020 Jun;80:108364
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4
Molecular cell 2020 Jul 2;79(1):30-42.e4
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE
Journal of lipid research 2020 Jan;61(1):33-44
Journal of lipid research 2020 Jan;61(1):33-44
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Yang Y, Fu M, Li MD, Zhang K, Zhang B, Wang S, Liu Y, Ni W, Ong Q, Mi J, Yang X
Nature communications 2020 Jan 10;11(1):181
Nature communications 2020 Jan 10;11(1):181
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Luo Y, Peng J, Huang C, Cao Y
Ecotoxicology and environmental safety 2020 Aug;199:110714
Ecotoxicology and environmental safety 2020 Aug;199:110714
A critical role of VMP1 in lipoprotein secretion.
Morishita H, Zhao YG, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
eLife 2019 Sep 17;8
eLife 2019 Sep 17;8
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, Schmidt F, Friedrich M, Keye J, Wan J, Qin Y, Kühl AA, Qin Z, Siegmund B, Glauben R
EMBO molecular medicine 2019 Nov 7;11(11):e10698
EMBO molecular medicine 2019 Nov 7;11(11):e10698
Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.
Cruz ALS, Carrossini N, Teixeira LK, Ribeiro-Pinto LF, Bozza PT, Viola JPB
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Keenan SN, Meex RC, Lo JCY, Ryan A, Nie S, Montgomery MK, Watt MJ
Diabetes 2019 Mar;68(3):543-555
Diabetes 2019 Mar;68(3):543-555
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3712-3721
Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages.
Souza-Moreira L, Soares VC, Dias SDSG, Bozza PT
Scientific reports 2019 Dec 30;9(1):20304
Scientific reports 2019 Dec 30;9(1):20304
The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.
Li D, Zhao YG, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D, Zhang H
Cell reports 2019 Apr 9;27(2):343-358.e5
Cell reports 2019 Apr 9;27(2):343-358.e5
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B
EMBO reports 2018 Sep;19(9)
EMBO reports 2018 Sep;19(9)
Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.
Jin Y, Tan Y, Chen L, Liu Y, Ren Z
International journal of molecular sciences 2018 Nov 2;19(11)
International journal of molecular sciences 2018 Nov 2;19(11)
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
Montgomery MK, Mokhtar R, Bayliss J, Parkington HC, Suturin VM, Bruce CR, Watt MJ
Diabetes 2018 Apr;67(4):594-606
Diabetes 2018 Apr;67(4):594-606
A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats.
Kai M, Miyoshi M, Fujiwara M, Nishiyama Y, Inoue T, Maeshige N, Hamada Y, Usami M
The Journal of surgical research 2017 May 15;212:22-32
The Journal of surgical research 2017 May 15;212:22-32
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N
FEBS letters 2017 Dec;591(23):3819-3830
FEBS letters 2017 Dec;591(23):3819-3830
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.
Graffmann N, Ring S, Kawala MA, Wruck W, Ncube A, Trompeter HI, Adjaye J
Stem cells and development 2016 Aug 1;25(15):1119-33
Stem cells and development 2016 Aug 1;25(15):1119-33
Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.
Mori E, Fujikura J, Noguchi M, Nakao K, Matsubara M, Sone M, Taura D, Kusakabe T, Ebihara K, Tanaka T, Hosoda K, Takahashi K, Asaka I, Inagaki N, Nakao K
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
Metabolism: clinical and experimental 2016 Apr;65(4):543-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ADRP/Perilipin 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ADRP/Perilipin 2. This antibody recognizes human,mouse,rat antigen. The ADRP/Perilipin 2 antibody has been validated for the following applications: ELISA, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15294-1-AP(ADRP antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
