BS6720

antibody from Bioworld Technology, Inc
Targeting: RASA1 CM-AVM, GAP, p120, p120GAP, p120RASGAP, RASA
Provider product page for BS6720
Western blot
Immunohistochemistry

Antibody data

Product number
BS6720 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RASA1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RASA1.
Description
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RASA1 protein structure - BS6720 shown in red.