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- References [29]
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- Western blot [2]
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- Product number
- 11237-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11237-1-AP, RRID:AB_2179539
- Product name
- MIRO2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MIRO2 antibody (Cat. #11237-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proximity labeling unveils potential roles of the Miro2-CISD1 network in mitochondrial dynamics and neuronal differentiation.
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias.
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity.
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control.
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A.
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell.
Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes.
MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.
Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission.
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Miro proteins prime mitochondria for Parkin translocation and mitophagy.
Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
Principles of the mitochondrial fusion and fission cycle in neurons.
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Kang IK, Lee S, Moon TK, Han AR, Yu DB, Jung M, Kwak C, Seo JK, Rhee HW, Kim SW, Woo HN, Mun JY, Lee H
Communications biology 2026 Feb 9;9(1):195
Communications biology 2026 Feb 9;9(1):195
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias.
Kim WJ, Crosse EI, De Neef E, Etxeberria I, Sabio EY, Wang E, Bewersdorf JP, Lin KT, Lu SX, Belleville A, Fox N, Castro C, Zhang P, Fujino T, Lewis J, Rahman J, Zhang B, Winick JH, Lewis AM, Stanley RF, DeWolf S, Urben BM, Takizawa M, Krause T, Molina H, Chaligne R, Koppikar P, Molldrem J, Gigoux M, Merghoub T, Daniyan A, Chandran SS, Greenbaum BD, Klebanoff CA, Bradley RK, Abdel-Wahab O
Cell 2025 Jun 26;188(13):3422-3440.e24
Cell 2025 Jun 26;188(13):3422-3440.e24
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity.
Boulton DP, Hughes CJ, Vaira V, Del Gobbo A, Palleschi A, Locatelli M, Danis E, Raza M, Neumann AJ, Purdy SC, Lerma R, Meshki J, Ford HL, Prekeris R, Morrissey C, Caino MC
Cell reports 2025 Jan 28;44(1):115120
Cell reports 2025 Jan 28;44(1):115120
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control.
Liu B, Han Y, Jin Y, Ye M, Yang Z, Yang J, Zhu M, Zhao X, Jin Y, Yin Y
Nature communications 2025 Dec 5;17(1):833
Nature communications 2025 Dec 5;17(1):833
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
Shao W, Wang JJ, Niu ZH, Zhang K, Wang S, Wang YH, Tang YH, Wang CC, Hou SQ, Zhou DR, Zhang C, Lin N
Heliyon 2024 Sep 15;10(17):e36820
Heliyon 2024 Sep 15;10(17):e36820
MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A.
Kumar A, Larrea D, Pero ME, Infante P, Conenna M, Shin GJ, Van Elias V, Grueber WB, Di Marcotullio L, Area-Gomez E, Bartolini F
iScience 2024 Jun 21;27(6):109994
iScience 2024 Jun 21;27(6):109994
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell.
Wang Y, Yu Q, Liu S, Liu C, Ju Y, Song Q, Cheng D
Ecotoxicology and environmental safety 2024 Jan 15;270:115831
Ecotoxicology and environmental safety 2024 Jan 15;270:115831
Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2.
Dang W, Li F, Gao R, Zhang C, Cheng H, Wu Z, Yang T, Pan J, Tang X, Gao Y
International journal of molecular sciences 2024 Dec 13;25(24)
International journal of molecular sciences 2024 Dec 13;25(24)
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C, Shang J, Sun Z, Xia M, Gao D, Sun R, Li W, Wang F, Zhang J
Molecular neurobiology 2024 Aug;61(8):5047-5070
Molecular neurobiology 2024 Aug;61(8):5047-5070
Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes.
Zhuang A, Zhuang A, Chen Y, Qin Z, Zhu D, Ren L, Wei Y, Zhou P, Yue X, He F, Xu J, Ding C
eLife 2023 May 9;12
eLife 2023 May 9;12
MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.
Kumar A, Larrea D, Pero ME, Infante P, Conenna M, Shin GJ, Grueber WB, Di Marcotullio L, Area-Gomez E, Bartolini F
bioRxiv : the preprint server for biology 2023 Mar 16;
bioRxiv : the preprint server for biology 2023 Mar 16;
Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.
Coscia SM, Thompson CP, Tang Q, Baltrusaitis EE, Rhodenhiser JA, Quintero-Carmona OA, Ostap EM, Lakadamyali M, Holzbaur ELF
Journal of cell science 2023 Mar 1;136(5)
Journal of cell science 2023 Mar 1;136(5)
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
Brustovetsky T, Khanna R, Brustovetsky N
Cells 2023 Apr 29;12(9)
Cells 2023 Apr 29;12(9)
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.
Ng MYW, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz SW, Nakken S, Munson MJ, Simonsen A
Nature communications 2022 Oct 21;13(1):6283
Nature communications 2022 Oct 21;13(1):6283
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron 2022 Mar 16;110(6):967-976.e8
Neuron 2022 Mar 16;110(6):967-976.e8
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF
The EMBO journal 2022 Dec 15;41(24):e112006
The EMBO journal 2022 Dec 15;41(24):e112006
CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Brustovetsky T, Khanna R, Brustovetsky N
Cells 2021 Oct 17;10(10)
Cells 2021 Oct 17;10(10)
Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
Brustovetsky T, Khanna R, Brustovetsky N
Cells 2021 Nov 15;10(11)
Cells 2021 Nov 15;10(11)
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK
Science advances 2021 Nov 12;7(46):eabj0722
Science advances 2021 Nov 12;7(46):eabj0722
miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission.
Woo HN, Park S, Kim HL, Jung MK, Pack CG, Park J, Cho Y, Jo DG, Kim DK, Mook-Jung I, Kim SW, Lee H
Molecular therapy. Nucleic acids 2021 Mar 5;23:643-656
Molecular therapy. Nucleic acids 2021 Mar 5;23:643-656
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Wang F, Chen X, Cheng H, Song L, Liu J, Caplan S, Zhu L, Wu JY
EMBO reports 2021 Jul 5;22(7):e52006
EMBO reports 2021 Jul 5;22(7):e52006
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286
Nature cell biology 2021 Dec;23(12):1271-1286
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Scott HL, Buckner N, Fernandez-Albert F, Pedone E, Postiglione L, Shi G, Allen N, Wong LF, Magini L, Marucci L, O'Sullivan GA, Cole S, Powell J, Maycox P, Uney JB
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L
Biochemical pharmacology 2020 Jul;177:113997
Biochemical pharmacology 2020 Jul;177:113997
Miro proteins prime mitochondria for Parkin translocation and mitophagy.
Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A
The EMBO journal 2019 Jan 15;38(2)
The EMBO journal 2019 Jan 15;38(2)
Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N
EMBO reports 2019 Dec 5;20(12):e47728
EMBO reports 2019 Dec 5;20(12):e47728
Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
Lee CA, Chin LS, Li L
Protein & cell 2018 Aug;9(8):693-716
Protein & cell 2018 Aug;9(8):693-716
Principles of the mitochondrial fusion and fission cycle in neurons.
Cagalinec M, Safiulina D, Liiv M, Liiv J, Choubey V, Wareski P, Veksler V, Kaasik A
Journal of cell science 2013 May 15;126(Pt 10):2187-97
Journal of cell science 2013 May 15;126(Pt 10):2187-97
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ
Biochemistry 2009 Mar 10;48(9):2045-52
Biochemistry 2009 Mar 10;48(9):2045-52
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 11237-1-AP(RHOT2 antibody) at dilution of 1:1000
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 11237-1-AP(RHOT2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 11237-1-AP(RHOT2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RHOT2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RHOT2. This antibody recognizes human, mouse antigen. The RHOT2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
