Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 11739-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11739-1-AP, RRID:AB_2059675
- Product name
- ASGR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ASGR1 antibody (Cat. #11739-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Silencing of lncRNA HOTAIR Using Eyedrops as a Potential Treatment for Diabetes-Associated Retinal Dysregulation and Dysfunction.
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway.
Tumor-specific glyco-detonators: A neuraminidase-3-gated programmable DNA Nanoarchitectonics for liver cancer-exclusive chemotherapy.
Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.
Filter-aided expansion proteomics for the spatial analysis of single cells and organelles in FFPE tissue samples.
Ebola virus' hidden target: virus transmission to and infection of skin.
Lipid nanoparticle-mediated mRNA delivery to CD34(+) cells in rhesus monkeys.
Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver.
Characterizing Antibodies Targeting Antisense Oligonucleotide Phosphorothioate and 2'-O-Methoxyethyl Modifications for Intracellular Trafficking and Biodistribution Studies.
A Soluble Triantennary N-Acetylgalactosamine Camptothecin Prodrug for Hepatocellular Carcinoma-Targeted Therapy.
Compositional and topological determinants of a physiological Ashwell-Morell receptor ligand.
Targeted protein degradation combined with PET imaging reveals the role of host PD-L1 in determining anti-PD-1 therapy efficacy.
Spatial proteomics of single cells and organelles on tissue slides using filter-aided expansion proteomics.
Notch1 regulates hepatic thrombopoietin production.
Temporal restriction of Cas9 expression improves CRISPR-mediated deletion efficacy and fidelity.
Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity.
ASGR1 is a promising target for lipid reduction in pigs with PON2 as its inhibitor.
Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity.
Decellularized Liver Nanofibers Enhance and Stabilize the Long-Term Functions of Primary Human Hepatocytes In Vitro.
ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway.
Liver cancer cells as the model for developing liver-targeted RNAi therapeutics.
ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply.
Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low-Density Lipoproteins and Increasing Their Uptake by Macrophages.
Regulated control of gene therapies by drug-induced splicing.
Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood.
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo.
Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis.
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models.
Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor.
The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation.
Wang E, Feng B, Chen S, Wang H, Ling T, Chakrabarti S
Investigative ophthalmology & visual science 2026 Jan 5;67(1):24
Investigative ophthalmology & visual science 2026 Jan 5;67(1):24
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.
Shi J, Li Q, Li J, Bai J, Xi J, He Q, Zhou J, Wang X, Song X, Li X, Yue X, Zhang X, Sun Z, Li J, Yang W, Cui Y, Shu W, Guo L, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e10275
Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway.
Zhang Z, Chen X, Hu X, Liang J, Huang H, Lu W, Zhu M, Fang M, Yin L, Li W, Zhang S
Journal of nanobiotechnology 2026 Feb 27;24(1)
Journal of nanobiotechnology 2026 Feb 27;24(1)
Tumor-specific glyco-detonators: A neuraminidase-3-gated programmable DNA Nanoarchitectonics for liver cancer-exclusive chemotherapy.
Li L, Hu J, Yang W, Li J
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114495
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114495
Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation.
Shi W, Sun Y, Liu K, Zhang Y, Lu L, Zhou Q, Pu Y, Sun R, Yin L
Environment international 2026 Apr;210:110220
Environment international 2026 Apr;210:110220
Filter-aided expansion proteomics for the spatial analysis of single cells and organelles in FFPE tissue samples.
Dong Z, Wu C, Chen J, Jiang W, Piatkevich KD, Zhu Y, Guo T
Nature protocols 2025 Oct 9;
Nature protocols 2025 Oct 9;
Ebola virus' hidden target: virus transmission to and infection of skin.
Richards PT, Fleck AM, Patel R, Fakhimi M, Bohan D, Geoghegan-Barek K, Honko AN, Stolte AE, Plescia CB, Messingham CO, Connell SJ, Crowe TP, Gourronc FA, Carrion R Jr, Griffiths A, Meyerholz DK, Klingelhutz AJ, Davey RA, Messingham KN, Maury W
Journal of virology 2025 Oct 23;99(10):e0130025
Journal of virology 2025 Oct 23;99(10):e0130025
Lipid nanoparticle-mediated mRNA delivery to CD34(+) cells in rhesus monkeys.
Kim H, Zenhausern R, Gentry K, Lian L, Huayamares SG, Radmand A, Loughrey D, Podilapu AR, Hatit MZC, Ni H, Li A, Shajii A, Peck HE, Han K, Hua X, Jia S, Martinez M, Lee C, Santangelo PJ, Tarantal A, Dahlman JE
Nature biotechnology 2025 Nov;43(11):1813-1820
Nature biotechnology 2025 Nov;43(11):1813-1820
Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver.
Aguila M, Cnubben NHP, Parfitt DA, Albuquerque B, de Visser PC, Molendijk M, Marques L, van Berkel M, Platenburg GJ
Scientific reports 2025 Nov 24;15(1):41494
Scientific reports 2025 Nov 24;15(1):41494
Characterizing Antibodies Targeting Antisense Oligonucleotide Phosphorothioate and 2'-O-Methoxyethyl Modifications for Intracellular Trafficking and Biodistribution Studies.
Fial I, Farrier SA, Chimento DP, Ascoli CA, Wan X, Oliver PL
Nucleic acid therapeutics 2025 Aug;35(4):168-181
Nucleic acid therapeutics 2025 Aug;35(4):168-181
A Soluble Triantennary N-Acetylgalactosamine Camptothecin Prodrug for Hepatocellular Carcinoma-Targeted Therapy.
Li Y, Zheng Y, Liu T, Zhao J, Zhou L, Yang X, Yao Z, Wang X, Fu Y, Wang J, Yuan K, He Z
Journal of medicinal chemistry 2025 Aug 14;68(15):15563-15578
Journal of medicinal chemistry 2025 Aug 14;68(15):15563-15578
Compositional and topological determinants of a physiological Ashwell-Morell receptor ligand.
Hintze J, Fraumeni R, de Haan N, Miller RL, Saraswat M, Yang Z, Clausen H, Marth JD
Proceedings of the National Academy of Sciences of the United States of America 2025 Apr 15;122(15):e2427129122
Proceedings of the National Academy of Sciences of the United States of America 2025 Apr 15;122(15):e2427129122
Targeted protein degradation combined with PET imaging reveals the role of host PD-L1 in determining anti-PD-1 therapy efficacy.
Du J, Han S, Zhou H, Wang J, Wang F, Zhao M, Song R, Li K, Zhu H, Zhang W, Yang Z, Liu Z
European journal of nuclear medicine and molecular imaging 2024 Oct;51(12):3559-3571
European journal of nuclear medicine and molecular imaging 2024 Oct;51(12):3559-3571
Spatial proteomics of single cells and organelles on tissue slides using filter-aided expansion proteomics.
Dong Z, Jiang W, Wu C, Chen T, Chen J, Ding X, Zheng S, Piatkevich KD, Zhu Y, Guo T
Nature communications 2024 Oct 30;15(1):9378
Nature communications 2024 Oct 30;15(1):9378
Notch1 regulates hepatic thrombopoietin production.
Sun Y, Tong H, Chu X, Li Y, Zhang J, Ding Y, Zhang S, Gui X, Chen C, Xu M, Li Z, Gardiner EE, Andrews RK, Zeng L, Xu K, Qiao J
Blood 2024 Jun 27;143(26):2778-2790
Blood 2024 Jun 27;143(26):2778-2790
Temporal restriction of Cas9 expression improves CRISPR-mediated deletion efficacy and fidelity.
Weber JA, Lang JF, Carrell EM, Alameh MG, Davidson BL
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102172
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102172
Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity.
Yu X, Tao J, Wu Y, Chen Y, Li P, Yang F, Tang M, Sammad A, Tao Y, Xu Y, Li YX
Diabetes & metabolism journal 2024 Jul;48(4):802-815
Diabetes & metabolism journal 2024 Jul;48(4):802-815
ASGR1 is a promising target for lipid reduction in pigs with PON2 as its inhibitor.
Yin Y, Liu J, Yu J, Dong D, Gao F, Yu L, Du X, Wu S
iScience 2024 Jul 19;27(7):110288
iScience 2024 Jul 19;27(7):110288
Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity.
Ye W, Tang Q, Zhou T, Zhou C, Fan C, Wang X, Wang C, Zhang K, Liao G, Zhou W
European journal of medicinal chemistry 2024 Jan 15;264:115988
European journal of medicinal chemistry 2024 Jan 15;264:115988
Decellularized Liver Nanofibers Enhance and Stabilize the Long-Term Functions of Primary Human Hepatocytes In Vitro.
Liu JS, Madruga LYC, Yuan Y, Kipper MJ, Khetani SR
Advanced healthcare materials 2023 Jul;12(19):e2202302
Advanced healthcare materials 2023 Jul;12(19):e2202302
ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway.
Shi R, Wang J, Zhang Z, Leng Y, Chen AF
Life sciences 2023 Feb 15;315:121339
Life sciences 2023 Feb 15;315:121339
Liver cancer cells as the model for developing liver-targeted RNAi therapeutics.
Hou B, Qin L, Huang L
Biochemical and biophysical research communications 2023 Feb 12;644:85-94
Biochemical and biophysical research communications 2023 Feb 12;644:85-94
ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
Ma WK, Voss DM, Scharner J, Costa ASH, Lin KT, Jeon HY, Wilkinson JE, Jackson M, Rigo F, Bennett CF, Krainer AR
Cancer research 2022 Mar 1;82(5):900-915
Cancer research 2022 Mar 1;82(5):900-915
Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy.
Jiang T, Xu L, Zhao M, Kong F, Lu X, Tang C, Yin C
Biomaterials 2022 Jan;280:121324
Biomaterials 2022 Jan;280:121324
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply.
Du K, Li S, Li C, Li P, Miao C, Luo T, Qiu B, Ding W
Acta biomaterialia 2021 Oct 15;134:228-239
Acta biomaterialia 2021 Oct 15;134:228-239
Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low-Density Lipoproteins and Increasing Their Uptake by Macrophages.
Demina EP, Smutova V, Pan X, Fougerat A, Guo T, Zou C, Chakraberty R, Snarr BD, Shiao TC, Roy R, Orekhov AN, Miyagi T, Laffargue M, Sheppard DC, Cairo CW, Pshezhetsky AV
Journal of the American Heart Association 2021 Feb 16;10(4):e018756
Journal of the American Heart Association 2021 Feb 16;10(4):e018756
Regulated control of gene therapies by drug-induced splicing.
Monteys AM, Hundley AA, Ranum PT, Tecedor L, Muehlmatt A, Lim E, Lukashev D, Sivasankaran R, Davidson BL
Nature 2021 Aug;596(7871):291-295
Nature 2021 Aug;596(7871):291-295
Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood.
Matsumoto A, Takahashi Y, Ogata K, Kitamura S, Nakagawa N, Yamamoto A, Ishihama Y, Takakura Y
iScience 2021 Aug 20;24(8):102839
iScience 2021 Aug 20;24(8):102839
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo.
Hajj KA, Melamed JR, Chaudhary N, Lamson NG, Ball RL, Yerneni SS, Whitehead KA
Nano letters 2020 Jul 8;20(7):5167-5175
Nano letters 2020 Jul 8;20(7):5167-5175
Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis.
Li J, Liu H, Mauer AS, Lucien F, Raiter A, Bandla H, Mounajjed T, Yin Z, Glaser KJ, Yin M, Malhi H
Hepatology communications 2019 Sep;3(9):1235-1249
Hepatology communications 2019 Sep;3(9):1235-1249
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models.
Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Sep 4;27(9):1547-1557
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Sep 4;27(9):1547-1557
Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor.
Scharner J, Qi S, Rigo F, Bennett CF, Krainer AR
Molecular therapy. Nucleic acids 2019 Jun 7;16:313-325
Molecular therapy. Nucleic acids 2019 Jun 7;16:313-325
The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation.
Velkova A, Diaz JEL, Pangilinan F, Molloy AM, Mills JL, Shane B, Sanchez E, Cunningham C, McNulty H, Cropp CD, Bailey-Wilson JE, Wilson AF, Brody LC
Human molecular genetics 2017 Dec 15;26(24):4975-4988
Human molecular genetics 2017 Dec 15;26(24):4975-4988
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 11739-1-AP(ASGR1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 11739-1-AP(ASGR1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The ASGR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ASGR1. This antibody recognizes human, mouse, rat antigen. The ASGR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.