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Western blot
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- Antibody Data
- Antigen structure
- References [1]
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- Product number
- PA5-79118 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- NOX2 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 500 µg/mL
- Storage
- -20°C
Submitted references Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney.
Lazar AG, Vlad ML, Manea A, Simionescu M, Manea SA
Antioxidants (Basel, Switzerland) 2021 Aug 26;10(9)
Antioxidants (Basel, Switzerland) 2021 Aug 26;10(9)
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Figure 4 Pharmacological inhibition of histone acetyltransferase p300/CBP by C646 mitigates the glomerular expression of Nox subtypes in diabetic mice. ( A , C , E ) Quantification of fluorescence immunolabeling for glomerular Nox1, Nox2, and Nox4 subtypes. ( B , D , F ) Representative IF microscopy images taken at 40x magnification depicting the immunofluorescence staining (red) for Nox subtypes. Sections were counterstained with DAPI (blue) stain to detect the cell nuclei in the specimens. Note that the up-regulation of glomerular Nox1, Nox2, and Nox4 protein levels in diabetic mice is blunted following C646 treatment. n = 14-19/condition quantified glomeruli, *** p < 0.001, p -values taken in relation to non-diabetic + vehicle condition; ### p < 0.001, p -values taken in relation to diabetic + vehicle condition.
