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- References [9]
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- Product number
- 21903-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Nectin-4/PVRL4 antibody
- Antibody type
- Polyclonal
- Description
- Nectin-4/PVRL4 antibody (Cat. #21903-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references On-target/off-tumor toxicities following infusion of low-affinity Nectin-4-specific CAR T cells.
Preliminary biological evaluation of a [(177)Lu]Lu-labeled peptide targeting Nectin-4.
Integrin β4 drives immune evasion and therapeutic resistance to PD-1 blockade in bladder cancer via MEK/ERK signaling.
Expression and Prognostic Significance of Different Antibody-Drug Conjugate Target Proteins in Urachal Carcinoma.
METTL3-mediated m (6)A modification facilitates Nectin-4-induced VNN1 upregulation and promotion of ESCC progression.
Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion.
Chemotherapy with gemcitabine and cisplatin downregulates tumor expression level of nectin-4 in a syngeneic model of murine MBT2 urothelial cancer cell line and C3H mice.
Upregulation of nectin-4 is associated with ITGB1 and vasculogenic mimicry and may serve as a predictor of poor prognosis in colorectal cancer.
MiR-31 and miR-128 regulates poliovirus receptor-related 4 mediated measles virus infectivity in tumors.
Ma L, Wang J, Li J, Yang W, Wen M, Yao M, Zhang K, Jiang T, Ren F, Liu D, Shen M, Deng H, Hong Y, Yuan S, Xia X, Lu X, Cao H, Liu Z, Ma X, Li B, Jason-Sun H
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1435-1447
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1435-1447
Preliminary biological evaluation of a [(177)Lu]Lu-labeled peptide targeting Nectin-4.
Li D, Zhang Y, Mu C, Cao X, Chen M, Li X, Chen W, Li Z
EJNMMI radiopharmacy and chemistry 2026 Mar 30;11(1)
EJNMMI radiopharmacy and chemistry 2026 Mar 30;11(1)
Integrin β4 drives immune evasion and therapeutic resistance to PD-1 blockade in bladder cancer via MEK/ERK signaling.
Lin P, Xing Z, Hong Y, Xu H, Shao S, Luo L, Zhao Y, Jin X, Li Y
The Journal of biological chemistry 2026 Jan;302(1):110941
The Journal of biological chemistry 2026 Jan;302(1):110941
Expression and Prognostic Significance of Different Antibody-Drug Conjugate Target Proteins in Urachal Carcinoma.
Han T, Cui H, Du G, Guan Y, Bi X, Guo L, Shi H, Shou J
Clinical genitourinary cancer 2025 Oct;23(5):102403
Clinical genitourinary cancer 2025 Oct;23(5):102403
METTL3-mediated m (6)A modification facilitates Nectin-4-induced VNN1 upregulation and promotion of ESCC progression.
Long Y, Yang H, Zhang R, Zhao Q, Yang M, Song G, Liu K
Acta biochimica et biophysica Sinica 2025 Jul 30;58(2):353-368
Acta biochimica et biophysica Sinica 2025 Jul 30;58(2):353-368
Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion.
Cai Q, Sun N, Zhang Y, Wang J, Pan C, Chen Y, Li L, Li X, Liu W, Aliyari SR, Yang H, Cheng G
Cell & bioscience 2024 Feb 17;14(1):23
Cell & bioscience 2024 Feb 17;14(1):23
Chemotherapy with gemcitabine and cisplatin downregulates tumor expression level of nectin-4 in a syngeneic model of murine MBT2 urothelial cancer cell line and C3H mice.
Miyake M, Oda Y, Nishimura N, Shimizu T, Fujii T, Fujimoto K
International journal of urology : official journal of the Japanese Urological Association 2023 Mar;30(3):328-330
International journal of urology : official journal of the Japanese Urological Association 2023 Mar;30(3):328-330
Upregulation of nectin-4 is associated with ITGB1 and vasculogenic mimicry and may serve as a predictor of poor prognosis in colorectal cancer.
Zhang J, Liu K, Peng P, Li S, Ye Z, Su Y, Liu S, Qin M, Huang J
Oncology letters 2019 Aug;18(2):1163-1170
Oncology letters 2019 Aug;18(2):1163-1170
MiR-31 and miR-128 regulates poliovirus receptor-related 4 mediated measles virus infectivity in tumors.
Geekiyanage H, Galanis E
Molecular oncology 2016 Nov;10(9):1387-1403
Molecular oncology 2016 Nov;10(9):1387-1403
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PVRL4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PVRL4. This antibody recognizes human, mouse antigen. The PVRL4 antibody has been validated for the following applications: ELISA, WB analysis.
