PLA2G10

This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

Description

Phospholipase A2 group X

Tissue specificity

Group enriched (intestine, pancreas, stomach)

Predicted location

Secreted in other tissues

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
RAS pathway related proteins

Chromosome

16 (14672548 - 14694308)

Ensembl ID

ENSG00000069764  (ver. 103.38)

Orthologs

Mouse Pla2g10: ENSMUSG00000022683

UniProt

O15496

neXtProt

NX_O15496

Human splice variants
Mouse splice variants

Protein structure