Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 303201 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#303201, RRID:AB_314333
- Product name
- Purified anti-human CD32
- Antibody type
- Monoclonal
- Antigen
- CD32
- Description
- CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies.
C-reactive protein and annexin A5 bind to distinct sites of negatively charged phospholipids present in oxidized low-density lipoprotein.
Satta N, Kruithof EK, Fickentscher C, Dunoyer-Geindre S, Boehlen F, Reber G, Burger D, de Moerloose P
Blood 2011 May 19;117(20):5523-31
Blood 2011 May 19;117(20):5523-31
C-reactive protein and annexin A5 bind to distinct sites of negatively charged phospholipids present in oxidized low-density lipoprotein.
van Tits L, de Graaf J, Toenhake H, van Heerde W, Stalenhoef A
Arteriosclerosis, thrombosis, and vascular biology 2005 Apr;25(4):717-22
Arteriosclerosis, thrombosis, and vascular biology 2005 Apr;25(4):717-22
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes stained with purified FUN-2, followed by anti-mouse IgGs FITC
- Conjugate
- Unconjugated