HIVEP1

This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

Description

HIVEP zinc finger 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

6 (12008762 - 12164999)

Ensembl ID

ENSG00000095951  (ver. 103.38)

Orthologs

Mouse Hivep1: ENSMUSG00000021366

UniProt

P15822

neXtProt

NX_P15822

Human splice variants
Mouse splice variants

Protein structure