Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 12281-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12281-1-AP, RRID:AB_10640429
- Product name
- LEO1 antibody
- Antibody type
- Polyclonal
- Description
- LEO1 antibody (Cat. #12281-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inherited blood cancer predisposition through altered transcription elongation.
CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer.
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Zhao J, Cato LD, Arora UP, Bao EL, Bryant SC, Williams N, Jia Y, Goldman SR, Nangalia J, Erb MA, Vos SM, Armstrong SA, Sankaran VG
Cell 2024 Feb 1;187(3):642-658.e19
Cell 2024 Feb 1;187(3):642-658.e19
CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
Qiu M, Yin Z, Wang H, Lei L, Li C, Cui Y, Dai R, Yang P, Xiang Y, Li Q, Lv J, Hu Z, Chen M, Zhou HB, Fang P, Xiao R, Liang K
Science advances 2023 May 19;9(20):eadf8698
Science advances 2023 May 19;9(20):eadf8698
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer.
Xiang G, Wang S, Chen L, Song M, Song X, Wang H, Zhou P, Ma X, Yu J
Cell death & disease 2022 May 12;13(5):451
Cell death & disease 2022 May 12;13(5):451
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM
Nature neuroscience 2019 Jun;22(6):863-874
Nature neuroscience 2019 Jun;22(6):863-874
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 12281-1-AP(LEO1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using LEO1 antibody 12281-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line