KCNC1

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both ""b"" and ""alpha"", while the shorter isoform has been called both ""a"" and ""beta"" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Description

Potassium voltage-gated channel subfamily C member 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Nuclear membrane, Vesicles, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

11:p15.1 (17734774 - 17856804)

Ensembl ID

ENSG00000129159  (ver. 103.38)

Orthologs

Mouse Kcnc1: ENSMUSG00000058975

UniProt

P48547

neXtProt

NX_P48547

Human splice variants
Mouse splice variants