17138-1-AP

antibody from Proteintech Group

Targeting: ACSS1 ACAS2L, AceCS2L, dJ568C11.3, MGC33843

Provider product page for 17138-1-AP

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]

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Product number: 17138-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17138-1-AP, RRID:AB_2289182
Product name: ACSS1 antibody
Antibody type: Polyclonal
Description: KD/KO validated ACSS1 antibody (Cat. #17138-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACSS1 protein structure - 17138-1-AP shown in red.

Submitted references β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice.

Chocron ES, Zhang D, Sumawi B, Schell J, Cruz D, Li G, Sreenivas P, Jiang H, Dong FF, Munkácsy E, Zhao S, Porras MAG, Gius D
International journal of biological sciences 2026;22(3):1070-1081

Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas.

Basappa J, Goldman AR, Lobello C, Wang S, Rushmore D, Melnikov O, Sen NV, Mallikarjuna VS, Jain P, Edalati M, Nelson DS, Cai KQ, Lu P, Nejati R, Borghaei H, Gupta PK, Nath K, Wellen KE, Wasik MA
Cancer letters 2026 Jul 1;649:218488

Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.

Liu G, Zhang H, Chen S, Gao J, Zhao H, Dong Y, Liu C, Wei X, Li T, Lu C, Zhu H, Lu D, Feng S, Li T, Zhang W, Xia Q, Man J, Zhou T, Chen J, Li A, Pan X
Cancer research 2025 Sep 15;85(18):3416-3434

IGF1R deficiency mitigates acute lung injury by promoting anti-inflammatory transcriptional profiles.

Urtubia A, Piñeiro-Hermida S, Alfaro-Arnedo E, Beni-Ledesma J, Canalejo M, de Toro M, Pichel JG, López IP
Respiratory research 2025 Oct 22;26(1):292

The key role of acss1 in mammary gland development and lactation: a study based on gene co-expression network analysis.

Wang F, Wang L, Zou L, Zhang X, Yang Q, Jiao B, Gao S, Tong L, Wang H
BMC genomics 2025 Oct 15;26(1):921

SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.

Li W, Han J, Huang B, Xu T, Wan Y, Luo D, Kong W, Yu Y, Zhang L, Nian Y, Chu B, Yin C
The EMBO journal 2025 Mar;44(6):1641-1662

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA.

Hu W, Wang X, Fang Z, Zhang J, Tirumalasetty MB, Miao QR
Cell reports 2025 Jul 22;44(7):115947

ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.

Wang M, Wen X, Feng Z, Choubey M, Chen S, Pan R, Gong K, Tirumalasetty MB, Gao F, Liao C, Yin Z, Zhang S, He Y, Chen H, Cao Y, Miao QR, Hu W, Duan Y
Nature communications 2025 Jul 1;16(1):5491

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.

Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31

Ageing-associated gut dysbiosis deteriorates mouse cognition.

Ju H, Zhou Y, Wei W, Hu Y, Fang H, Chen Z, Sun X, Shi Y, Fang H
Acta biochimica et biophysica Sinica 2025 Feb 13;57(8):1234-1243

ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer.

Fu X, Zhu Y, Lu X, Gao X, Xin L, Ren Y, Liu X, Ge L, Hao J, Yao Z, Shi L, Yang J
Cell death & disease 2025 Dec 18;17(1):119

Identification of hub glutamine metabolism-associated genes and immune characteristics in pre-eclampsia.

Mao Y, Li X, Ren R, Yuan Y, Wang L, Zhang X
PloS one 2024;19(5):e0303471

Acetate enables metabolic fitness and cognitive performance during sleep disruption.

He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.

Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8

Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc.

Wang J, Yang Y, Shao F, Meng Y, Guo D, He J, Lu Z
Nature metabolism 2024 May;6(5):914-932

Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression.

Qin L, Berk M, Chung YM, Cui D, Zhu Z, Chakraborty AA, Sharifi N
Cell reports 2024 Jan 23;43(1):113575

Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice.

Liu MY, Xu KH, Liu S, Xiao WJ
Molecular nutrition & food research 2024 Dec;68(23):e2400766

ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis.

Hlavaty SI, Salcido KN, Pniewski KA, Mukha D, Ma W, Kannan T, Cassel J, Srikanth YVV, Liu Q, Kossenkov A, Salvino JM, Chen Q, Schug ZT
Cell reports 2024 Dec 24;43(12):114988

Acetic acid affects porcine oocyte metabolism and improves oocyte developmental ability.

Inoue Y, Hayashi M, Shirasuna K, Iwata H
Theriogenology 2024 Aug;224:174-182

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.

Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T
Nature 2023 Oct;622(7983):619-626

Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.

Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT
Nature cancer 2023 Oct;4(10):1491-1507

Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment.

Liu D, Dong C, Wang F, Liu W, Jin X, Qi SL, Liu L, Jin Q, Wang S, Wu J, Wang C, Yang J, Deng H, Cai Y, Yang L, Qin J, Zhang C, Yang X, Wang MS, Yu G, Xue YW, Wang Z, Ge GB, Xu Z, Chen WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154732

Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells.

Calhoun S, Duan L, Maki CG
Translational oncology 2022 May;19:101386

Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.

Zhou W, Nie ZW, Zhou DJ, Cui XS
Journal of cellular physiology 2021 Oct;236(10):6948-6962

Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples.

Sun X, Zhang J, Nie Q
PLoS computational biology 2021 Mar;17(3):e1008379

NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma.

Odera JO, Xiong Z, Huang C, Gu N, Yang W, Githang'a J, Odera E, Paiboonrungruang C, Chen X
The Biochemical journal 2020 Aug 28;477(16):3075-3089

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.

Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T, Boettger T
The EMBO journal 2017 May 2;36(9):1199-1214

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.

Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE, Naidu SR
The Journal of biological chemistry 2016 Oct 14;291(42):21869-21879

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

Gao X, Lin SH, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang PY, Lei QY
Nature communications 2016 Jun 30;7:11960

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ACSS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACSS1. This antibody recognizes human, mouse, rat antigen. The ACSS1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17138-1-AP.pdf

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