Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 13318-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13318-1-AP, RRID:AB_2080270
- Product name
- CISD2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CISD2 antibody (Cat. #13318-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Biochemical and cellular characterization of the CISD3 protein: Molecular bases of cluster release and destabilizing effects of nitric oxide.
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models.
Bulk RNA-sequencing, single-cell RNA-sequencing analysis, and experimental validation reveal iron metabolism-related genes CISD2 and CYP17A1 are potential diagnostic markers for recurrent pregnancy loss.
Comprehensive analysis of the prognostic implication and immune infiltration of CISD2 in diffuse large B-cell lymphoma.
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice.
Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.
CISD2 promotes lung squamous carcinoma cell migration and invasion via the TGF-β1-induced Smad2/3 signaling pathway.
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.
New Insights of the NEET Protein CISD2 Reveals Distinct Features Compared to Its Close Mitochondrial Homolog mitoNEET.
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
Cryogen spray cooling mitigates inflammation and injury-induced CISD2 decline in rat spinal cord hemisection model.
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics.
A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging.
Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways.
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway.
A donor splice site mutation in CISD2 generates multiple truncated, non-functional isoforms in Wolfram syndrome type 2 patients.
Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway.
A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma.
CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma.
Sampling the conformational space of the catalytic subunit of human γ-secretase.
CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer.
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.
Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.
Grifagni D, Silva JM, Querci L, Lepoivre M, Vallières C, Louro RO, Banci L, Piccioli M, Golinelli-Cohen MP, Cantini F
The Journal of biological chemistry 2024 Mar;300(3):105745
The Journal of biological chemistry 2024 Mar;300(3):105745
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models.
Martinez A, Sanchez-Martinez A, Pickering JT, Twyning MJ, Terriente-Felix A, Chen PL, Chen CH, Whitworth AJ
Molecular neurodegeneration 2024 Jan 25;19(1):12
Molecular neurodegeneration 2024 Jan 25;19(1):12
Bulk RNA-sequencing, single-cell RNA-sequencing analysis, and experimental validation reveal iron metabolism-related genes CISD2 and CYP17A1 are potential diagnostic markers for recurrent pregnancy loss.
He YB, Han L, Wang C, Fang J, Shang Y, Cai HL, Zhou Q, Zhang ZZ, Chen SL, Li JY, Liu YL
Gene 2024 Apr 5;901:148168
Gene 2024 Apr 5;901:148168
Comprehensive analysis of the prognostic implication and immune infiltration of CISD2 in diffuse large B-cell lymphoma.
Zhang C, Lin Q, Li C, Qiu Y, Chen J, Zhu X
Frontiers in immunology 2023;14:1277695
Frontiers in immunology 2023;14:1277695
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice.
Li R, Zhang X, Gu L, Yuan Y, Luo X, Shen W, Xie Z
Journal of neurochemistry 2023 May;165(3):426-444
Journal of neurochemistry 2023 May;165(3):426-444
Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.
Zhou YX, Wei J, Deng G, Hu A, Sun PY, Zhao X, Song BL, Luo J
Nature cell biology 2023 Jul;25(7):937-949
Nature cell biology 2023 Jul;25(7):937-949
CISD2 promotes lung squamous carcinoma cell migration and invasion via the TGF-β1-induced Smad2/3 signaling pathway.
Zhang J, Pan L, Zhang S, Yang Y, Liang J, Ma S, Wu Q
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Dec;25(12):3527-3540
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Dec;25(12):3527-3540
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Ren X, Yu J, Guo L, Zhang Z
Metabolic brain disease 2022 Oct;37(7):2417-2429
Metabolic brain disease 2022 Oct;37(7):2417-2429
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.
Li B, Wei S, Yang L, Peng X, Ma Y, Wu B, Fan Q, Yang S, Li X, Jin H, Tang S, Huang M, Li H, Liu J
Frontiers in oncology 2021;11:657723
Frontiers in oncology 2021;11:657723
New Insights of the NEET Protein CISD2 Reveals Distinct Features Compared to Its Close Mitochondrial Homolog mitoNEET.
Salameh M, Riquier S, Guittet O, Huang ME, Vernis L, Lepoivre M, Golinelli-Cohen MP
Biomedicines 2021 Apr 5;9(4)
Biomedicines 2021 Apr 5;9(4)
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
Qin T, Cheng L, Xiao Y, Qian W, Li J, Wu Z, Wang Z, Xu Q, Duan W, Wong L, Wu E, Ma Q, Ma J
Frontiers in oncology 2020;10:1038
Frontiers in oncology 2020;10:1038
Cryogen spray cooling mitigates inflammation and injury-induced CISD2 decline in rat spinal cord hemisection model.
Kung WM, Chang CJ, Chen TY, Lin MS
Journal of integrative neuroscience 2020 Dec 30;19(4):619-628
Journal of integrative neuroscience 2020 Dec 30;19(4):619-628
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics.
Molino D, Pila-Castellanos I, Marjault HB, Dias Amoedo N, Kopp K, Rochin L, Karmi O, Sohn YS, Lines L, Hamaï A, Joly S, Radreau P, Vonderscher J, Codogno P, Giordano F, Machin P, Rossignol R, Meldrum E, Arnoult D, Ruggieri A, Nechushtai R, de Chassey B, Morel E
EMBO reports 2020 Dec 3;21(12):e49019
EMBO reports 2020 Dec 3;21(12):e49019
A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging.
Curley M, Milne L, Smith S, Jørgensen A, Frederiksen H, Hadoke P, Potter P, Smith LB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):978-995
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):978-995
Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways.
Cheng L, Yan B, Chen K, Jiang Z, Zhou C, Cao J, Qian W, Li J, Sun L, Ma J, Ma Q, Sha H
Oxidative medicine and cellular longevity 2018;2018:9482018
Oxidative medicine and cellular longevity 2018;2018:9482018
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen MP
PloS one 2018;13(3):e0194782
PloS one 2018;13(3):e0194782
CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway.
Sun Y, Jiang Y, Huang J, Chen H, Liao Y, Yang Z
Cancer medicine 2017 Oct;6(10):2331-2346
Cancer medicine 2017 Oct;6(10):2331-2346
A donor splice site mutation in CISD2 generates multiple truncated, non-functional isoforms in Wolfram syndrome type 2 patients.
Cattaneo M, La Sala L, Rondinelli M, Errichiello E, Zuffardi O, Puca AA, Genovese S, Ceriello A
BMC medical genetics 2017 Dec 13;18(1):147
BMC medical genetics 2017 Dec 13;18(1):147
Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway.
Wang L, Ouyang F, Liu X, Wu S, Wu HM, Xu Y, Wang B, Zhu J, Xu X, Zhang L
Oncotarget 2016 Jan 26;7(4):3791-805
Oncotarget 2016 Jan 26;7(4):3791-805
A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma.
Yang L, Hong S, Wang Y, He Z, Liang S, Chen H, He S, Wu S, Song L, Chen Y
Oncotarget 2016 Apr 19;7(16):22720-32
Oncotarget 2016 Apr 19;7(16):22720-32
CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma.
Chen B, Shen S, Wu J, Hua Y, Kuang M, Li S, Peng B
International journal of clinical and experimental pathology 2015;8(10):13725-38
International journal of clinical and experimental pathology 2015;8(10):13725-38
Sampling the conformational space of the catalytic subunit of human γ-secretase.
Bai XC, Rajendra E, Yang G, Shi Y, Scheres SH
eLife 2015 Dec 1;4
eLife 2015 Dec 1;4
CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer.
Liu L, Xia M, Wang J, Zhang W, Zhang Y, He M
Medical oncology (Northwood, London, England) 2014 Sep;31(9):183
Medical oncology (Northwood, London, England) 2014 Sep;31(9):183
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.
Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 9;111(49):E5292-301
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 9;111(49):E5292-301
Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.
Jones MA, Amr S, Ferebee A, Huynh P, Rosenfeld JA, Miles MF, Davies AG, Korey CA, Warrick JM, Shiang R, Elsea SH, Girirajan S, Grotewiel M
Biology open 2014 Apr 4;3(5):342-52
Biology open 2014 Apr 4;3(5):342-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 13318-1-AP(CISD2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CISD2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CISD2. This antibody recognizes human,mouse,rat antigen. The CISD2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 13318-1-AP(CISD2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 13318-1-AP(CISD2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue