LNPEP

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

Leucyl and cystinyl aminopeptidase

Tissue specificity

Low tissue specificity

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (96935394 - 97037513)

Ensembl ID

ENSG00000113441  (ver. 103.38)

Orthologs

Mouse Lnpep: ENSMUSG00000023845

UniProt

Q9UIQ6

neXtProt

NX_Q9UIQ6

Human splice variants
Mouse splice variants

Protein structure