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- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 22658-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- EYA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EYA1 antibody (Cat. #22658-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrating Single-Cell and Microarray Data to Explore the Role of Autophagy-Related Gene Atg7 in Osteoporosis.
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.
Otic organoids: A model to study spiral ganglion neuron characteristics in Tmprss3-deficiency.
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
Zmym2 Alters Expression of Key Craniofacial Genes.
CRISPR-based editing strategies to rectify EYA1 complex genomic rearrangement linked to haploinsufficiency.
Mechanisms of pathogenicity and the quest for genetic modifiers of kidney disease in branchiootorenal syndrome.
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.
Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Early Wnt Signaling Activation Promotes Inner Ear Differentiation via Cell Caudalization in Mouse Stem Cell-Derived Organoids.
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.
SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.
EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.
Lin Z, Cheng Y, Tang Q, Zheng H, Li H, Lian Y
Journal of inflammation research 2026;19:579167
Journal of inflammation research 2026;19:579167
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.
Fleming AM, Jablonowski CM, Jin H, Zhang S, Sona S, Lee HW, Dieseldorff Jones KM, Cheng C, Xu B, Morton CL, Woolard MA, Pichavaram P, Gehle DB, Natarajan S, Kodali K, Pagala V, High AA, Kumar Y, Burden S, Valentine V, Daria D, Harbour J, Vocelle D, Chang TC, Easton J, Olsen SR, Neale G, Pinto EM, Rehg JE, Janke L, Santiago T, George RE, Ma X, Zambetti GP, Davidoff AM, Chen T, Wu G, Chen X, Yang J, Murphy AJ
Cell reports 2026 Mar 24;45(3):117063
Cell reports 2026 Mar 24;45(3):117063
Otic organoids: A model to study spiral ganglion neuron characteristics in Tmprss3-deficiency.
Deutschmann AU, Pifkova L, Findik B, Klingenstein M, Betz A, Klimiankou M, Skokowa J, Liebau S, Reisinger E, Klingenstein S
iScience 2026 Jan 16;29(1):114355
iScience 2026 Jan 16;29(1):114355
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
Wei T, Lin R, Lu Y, Jin DY, Zhang J, Sham MH
International journal of biological sciences 2025;21(3):1081-1096
International journal of biological sciences 2025;21(3):1081-1096
Zmym2 Alters Expression of Key Craniofacial Genes.
Jourdeuil K, Neilson KM, Tavares ALP, Moody SA
Genesis (New York, N.Y. : 2000) 2025 Jun;63(3):e70018
Genesis (New York, N.Y. : 2000) 2025 Jun;63(3):e70018
CRISPR-based editing strategies to rectify EYA1 complex genomic rearrangement linked to haploinsufficiency.
Yi H, Yun Y, Choi WH, Hwang HY, Cha JH, Seok H, Song JJ, Lee JH, Lee SY, Kim D
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102199
Molecular therapy. Nucleic acids 2024 Jun 11;35(2):102199
Mechanisms of pathogenicity and the quest for genetic modifiers of kidney disease in branchiootorenal syndrome.
Sewerin S, Aurnhammer C, Skubic C, Blagotinšek Cokan K, Jeruc J, Rozman D, Pfister F, Dittrich K, Mayer B, Schönauer R, Petzold F, Halbritter J
Clinical kidney journal 2024 Jan;17(1):sfad260
Clinical kidney journal 2024 Jan;17(1):sfad260
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.
Nelson CB, Rogers S, Roychoudhury K, Tan YS, Atkinson CJ, Sobinoff AP, Tomlinson CG, Hsu A, Lu R, Dray E, Haber M, Fletcher JI, Cesare AJ, Hegde RS, Pickett HA
Nature communications 2024 Feb 15;15(1):1385
Nature communications 2024 Feb 15;15(1):1385
Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.
Jourdeuil K, Neilson KM, Cousin H, Tavares ALP, Majumdar HD, Alfandari D, Moody SA
Frontiers in cell and developmental biology 2023;11:1274788
Frontiers in cell and developmental biology 2023;11:1274788
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Zhang CT, Qin DL, Cao XY, Kan JS, Huang XX, Gao DS, Gao J
iScience 2023 Jul 21;26(7):107049
iScience 2023 Jul 21;26(7):107049
Early Wnt Signaling Activation Promotes Inner Ear Differentiation via Cell Caudalization in Mouse Stem Cell-Derived Organoids.
Tang PC, Chen L, Singh S, Groves AK, Koehler KR, Liu XZ, Nelson RF
Stem cells (Dayton, Ohio) 2023 Jan 30;41(1):26-38
Stem cells (Dayton, Ohio) 2023 Jan 30;41(1):26-38
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
Fang Q, Tian GG, Wang Q, Liu M, He L, Li S, Wu J
Cell reports 2023 Apr 25;42(4):112403
Cell reports 2023 Apr 25;42(4):112403
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
Cui Q, Zhang D, Kong D, Tang J, Liao X, Yang Q, Ren J, Gong Y, Wu G
Stem cell research & therapy 2020 May 26;11(1):200
Stem cell research & therapy 2020 May 26;11(1):200
MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.
Gao J, Kang XY, Sun S, Li L, Gao DS
Journal of molecular neuroscience : MN 2020 Mar;70(3):328-339
Journal of molecular neuroscience : MN 2020 Mar;70(3):328-339
SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.
Kong D, Li A, Liu Y, Cui Q, Wang K, Zhang D, Tang J, Du Y, Liu Z, Wu G, Wu K
Frontiers in oncology 2019;9:1450
Frontiers in oncology 2019;9:1450
EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.
Kong D, Ma W, Zhang D, Cui Q, Wang K, Tang J, Liu Z, Wu G
American journal of translational research 2019;11(4):2328-2338
American journal of translational research 2019;11(4):2328-2338
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, Wu G
Clinical breast cancer 2018 Oct;18(5):e875-e882
Clinical breast cancer 2018 Oct;18(5):e875-e882
Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.
Zhou JJ, Huang Y, Zhang X, Cheng Y, Tang L, Ma X
Oncotarget 2017 Dec 1;8(62):105081-105092
Oncotarget 2017 Dec 1;8(62):105081-105092
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 22658-1-AP( EYA1 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 22658-1-AP(EYA1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EYA1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EYA1. This antibody recognizes human, mouse antigen. The EYA1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
