25-2269-42

antibody from Invitrogen Antibodies

Targeting: CD226 DNAM-1, DNAM1, PTA1, TLiSA1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

25-2269-42

Provider

Invitrogen Antibodies

Product name

CD226 (DNAM-1) Monoclonal Antibody (11A8.7.4), PE-Cyanine7, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

The monoclonal antibody 11A8.7.4 reacts to DNAM-1 also known as CD226. DNAM 1 is a 65 kD receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. The ligands for CD226 are the poliovirus receptor (PVR, CD155) and Poliovirus Related Receptor (PPR2, Nectin-2, CD112). CD226 is involved in cytolytic activity by interacting with integrins and activating protein tyrosine kinase Fyn.

Antibody clone number

11A8.7.4

Concentration

5 µL/Test

References

Submitted references

Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID-19.

Yan L, Cai B, Li Y, Wang MJ, An YF, Deng R, Li DD, Wang LC, Xu H, Gao XD, Wang LL
Journal of cellular and molecular medicine 2020 Dec;24(24):14270-14279

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with CD56 Monoclonal Antibody, Super Bright 645 (Product # 64-0566-42) and Mouse IgG1 K Isotype, PE-Cyanine7 (Product # 25-4714-80) (left) or CD226 Monoclonal Antibody, PE-Cyanine7 (right). Cells in the lymphocyte gate were used for analysis.