Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 316808 - Provider product page
- Provider
- BioLegend
- Product name
- Alexa Fluor® 647 anti-human CD226 (DNAM-1) [DX11]
- Antibody type
- Monoclonal
- Antigen
- Human cytotoxic T lymphocytes
- Description
- CD226 is a 65 kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to the immunoglobulin superfamily containing 2 Ig-like domain and is expressed on majority of T lymphocytes, NK cells, monocytes, and platelets as well as a subset of B cells and activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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