ST8SIA4

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

5:q21.1 (100806933 - 100903282)

Ensembl ID

ENSG00000113532  (ver. 103.38)

Orthologs

Mouse St8sia4: ENSMUSG00000040710

UniProt

Q92187

neXtProt

NX_Q92187

Human splice variants
Mouse splice variants