Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60752 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- TMPRSS15 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human TMPRSS15
- Description
- Enterokinase, also known as enteropeptidase or serine protease 7, belongs to the peptidase S1 family and localizes to the intestinal brush border in the proximal small intestine. It exists as a heterodimer of a catalytic light chain (LC) and a non-catalytic heavy chain (HC) linked together by a disulfide bond. Enterokinase HC plays a role in macromolecular substrate recognition and specificity. Duodenase is the serine protease responsible for the release and activation of Enterokinase from its inactive precursor. Active Enterokinase recognizes the target sequence, Asp-Asp-Asp-Asp-Lys, and is responsible for catalyzing the conversion of pancreatic trypsinogen to activated trypsin. Activated trypsin then further activates digestive enzymes such as chymotrypsin, carboxypeptidases, elastases and lipases, releasing them from their inactive precursors. Enterokinase is important for proper digestion of proteins. Improper functioning of Enterokinase may result in congenital enteropeptidase deficiency. This recessively inherited disorder leads to severe protein malabsorption and can result in low serum protein, chronic diarrhea and, in infants, a failure to thrive.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of TMPRSS15 pAb at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate