11463-1-AP
antibody from Proteintech Group
Targeting: COX4I2
COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [2]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11463-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11463-1-AP, RRID:AB_2085287
- Product name
- COX4I2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX4I2 antibody (Cat. #11463-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.
Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression.
Cytochrome c oxidase mediates labile iron level and radioresistance in glioblastoma.
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM.
COX4I2 is a novel biomarker of blood supply in adrenal tumors.
Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility.
Acute O(2) sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.
Gene expression analyses reveal metabolic specifications in acute O(2) -sensing chemoreceptor cells.
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.
Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.
Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas.
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.
Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611
Basic research in cardiology 2024 Aug;119(4):587-611
Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression.
Mao Y, Zhuo R, Ma W, Dai J, Alimu P, Fang C, Xu D, Ye L, Wang W, Sun F
Frontiers in oncology 2022;12:938123
Frontiers in oncology 2022;12:938123
Cytochrome c oxidase mediates labile iron level and radioresistance in glioblastoma.
Ali MY, Oliva CR, Flor S, Goswami PC, Griguer CE
Free radical biology & medicine 2022 May 20;185:25-35
Free radical biology & medicine 2022 May 20;185:25-35
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM.
Oliva CR, Ali MY, Flor S, Griguer CE
Cell stress 2022 Apr;6(4):45-60
Cell stress 2022 Apr;6(4):45-60
COX4I2 is a novel biomarker of blood supply in adrenal tumors.
Mao Y, Ma W, Zhuo R, Ye L, Xu D, Wang W, Ning G, Sun F
Translational andrology and urology 2021 Jul;10(7):2899-2909
Translational andrology and urology 2021 Jul;10(7):2899-2909
Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility.
Wen X, Xiong Y, Liu H, Geng T, Jin L, Zhang M, Ma L, Zhang Y
Journal of molecular endocrinology 2021 Jan;66(1):45-57
Journal of molecular endocrinology 2021 Jan;66(1):45-57
Acute O(2) sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J
Science signaling 2020 Jan 21;13(615)
Science signaling 2020 Jan 21;13(615)
Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?
Keller G, Binyamin O, Frid K, Saada A, Gabizon R
Neurobiology of disease 2019 Apr;124:57-66
Neurobiology of disease 2019 Apr;124:57-66
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J
Cell reports 2018 Oct 16;25(3):561-570.e6
Cell reports 2018 Oct 16;25(3):561-570.e6
Gene expression analyses reveal metabolic specifications in acute O(2) -sensing chemoreceptor cells.
Gao L, Bonilla-Henao V, García-Flores P, Arias-Mayenco I, Ortega-Sáenz P, López-Barneo J
The Journal of physiology 2017 Sep 15;595(18):6091-6120
The Journal of physiology 2017 Sep 15;595(18):6091-6120
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.
Oliva CR, Zhang W, Langford C, Suto MJ, Griguer CE
Oncotarget 2017 Jun 6;8(23):37568-37583
Oncotarget 2017 Jun 6;8(23):37568-37583
Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.
Aras S, Arrabi H, Purandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI
Biochimica et biophysica acta. Molecular cell research 2017 Feb;1864(2):440-448
Biochimica et biophysica acta. Molecular cell research 2017 Feb;1864(2):440-448
Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas.
Oliva CR, Markert T, Gillespie GY, Griguer CE
Oncotarget 2015 Feb 28;6(6):4330-44
Oncotarget 2015 Feb 28;6(6):4330-44
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C
Bioconjugate chemistry 2014 Apr 16;25(4):813-23
Bioconjugate chemistry 2014 Apr 16;25(4):813-23
Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.
Hicks S, Labinskyy N, Piteo B, Laurent D, Mathew JE, Gupte SA, Edwards JG
American journal of physiology. Heart and circulatory physiology 2013 Apr 1;304(7):H903-15
American journal of physiology. Heart and circulatory physiology 2013 Apr 1;304(7):H903-15
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.
Schneider L, Giordano S, Zelickson BR, S Johnson M, A Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J
Free radical biology & medicine 2011 Dec 1;51(11):2007-17
Free radical biology & medicine 2011 Dec 1;51(11):2007-17
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.
Oliva CR, Nozell SE, Diers A, McClugage SG 3rd, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE
The Journal of biological chemistry 2010 Dec 17;285(51):39759-67
The Journal of biological chemistry 2010 Dec 17;285(51):39759-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 11463-1-AP(COX4I2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using COX4I2 antibody 11463-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-COX4I2 (IP:11463-1-AP, 3ug; Detection:11463-1-AP 1:1000) with HepG2 cells lysate 8000ug.
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of anti-COX4I2 (11463-1-AP for IP and Detection) with HepG2 cell lysate.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 11463-1-AP(COX4I2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue