Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 367304 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#367304, RRID:AB_2565751
- Product name
- PE anti-human APCDD1 (DRAPC1)
- Antibody type
- Monoclonal
- Antigen
- Human APCDD1-His.
- Description
- APCDD1 (adenomatosis polyposis coli down-regulated 1), also known as B7323, DRAPC1, or FP7019, is a 514 amino acid single-pass type I membrane protein. APCDD1 is expressed in the gastrointestinal track, placental trophoblasts, and both epidermal and dermal compartments from human hair follicles. It is also weakly expressed in lymphoid tissues. APCDD1 has been reported to be directly regulated by the beta-catenin/ITF-2 complex and that its elevated expression promotes the proliferation of colonic epithelial cells. It is thought to function as a developmental target of the beta-catenin pathway and may play an important role in colorectal tumorigenesis. Recently, it was found to negatively regulate Wnt signaling in a cell-autonomous manner.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Antibody clone number
- 7.13
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human colon adenocarcinoma cell line (SW480) cells, were stained with APCDD1 (clone 7.13) PE or mouse IgG2a, κ PE isotype control.
- Conjugate
- Yellow dye