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- Antibody Data
- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 21988-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- PCCA antibody
- Antibody type
- Polyclonal
- Description
- PCCA antibody (Cat. #21988-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Generation of an isogenic human induced pluripotent stem cell line with a mutant propionyl-CoA carboxylase α subunit.
Icaritin Ameliorates Cisplatin-Induced Mitochondrial Metabolic Dysfunction-Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy.
Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation.
ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism.
Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis.
Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Holocarboxylase synthetase knockout is embryonic lethal in mice.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Metabolic perturbations mediated by propionyl-CoA accumulation in organs of mouse model of propionic acidemia.
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model.
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors.
Effects of adeno-associated virus serotype and tissue-specific expression on circulating biomarkers of propionic acidemia.
Tao T, Lin L, Tang Y, Liu Z, Liu Y, Xie Y, Hu X, Wang J, Wang T, Zhang GF, Wang Y, Zhu S
Orphanet journal of rare diseases 2026 Jan 23;21(1):61
Orphanet journal of rare diseases 2026 Jan 23;21(1):61
Icaritin Ameliorates Cisplatin-Induced Mitochondrial Metabolic Dysfunction-Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy.
Luo P, Chen J, An Y, Meng K, Zhou W, Li W, Liu J, Zhao W, He W, Cao T, Huang J, Feng S, Yang S, Hu H, Liao J, He H, Hao M, Zhang Q, Wang J, Gao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e06712
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e06712
Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation.
Mori H, Hariri H, Moe W, Durham S, Guzman Y, Paulsson E, Simmermon RC, Bhanderi PB, Peterson SK, Dickson MJ, Evans CR, MacDougald OA
bioRxiv : the preprint server for biology 2026 Apr 17;
bioRxiv : the preprint server for biology 2026 Apr 17;
ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
Wang L, Yuan H, Li W, Yan P, Zhao M, Li Z, Zhao H, Wang S, Wan R, Li Y, Yang J, Pan X, Rosas I, Yu G
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166960
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166960
PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism.
Li M, Zhang Y, Wang Z, Wang K, Gao J, Gu H, Zeng Z, Jiang H, Fan Q, Zhang Y, Hu X, Cui L, Deng Y, Sun Y
Cancer letters 2024 Dec 16;611:217402
Cancer letters 2024 Dec 16;611:217402
Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis.
Xu K, Ding L, Li W, Wang Y, Ma S, Lian H, Pan X, Wan R, Zhao W, Yang J, Rosas I, Wang L, Yu G
The American journal of pathology 2024 Aug;194(8):1478-1493
The American journal of pathology 2024 Aug;194(8):1478-1493
Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue.
Duerre DJ, Hansen JK, John S, Jen A, Carrillo N, Bui H, Bao Y, Fabregat M, Overmeyer K, Shishkova E, Keller MP, Anderson RA, Cryns VL, Attie AD, Coon JJ, Fan J, Galmozzi A
bioRxiv : the preprint server for biology 2023 Nov 28;
bioRxiv : the preprint server for biology 2023 Nov 28;
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951
EMBO molecular medicine 2023 Jul 10;15(7):e16951
Holocarboxylase synthetase knockout is embryonic lethal in mice.
Sadri M, Wang H, Kuroishi T, Li Y, Zempleni J
PloS one 2022;17(4):e0265539
PloS one 2022;17(4):e0265539
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Metabolic perturbations mediated by propionyl-CoA accumulation in organs of mouse model of propionic acidemia.
He W, Wang Y, Xie EJ, Barry MA, Zhang GF
Molecular genetics and metabolism 2021 Nov;134(3):257-266
Molecular genetics and metabolism 2021 Nov;134(3):257-266
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Jiang L, Park JS, Yin L, Laureano R, Jacquinet E, Yang J, Liang S, Frassetto A, Zhuo J, Yan X, Zhu X, Fortucci S, Hoar K, Mihai C, Tunkey C, Presnyak V, Benenato KE, Lukacs CM, Martini PGV, Guey LT
Nature communications 2020 Oct 21;11(1):5339
Nature communications 2020 Oct 21;11(1):5339
Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model.
Li Y, Dong J, Shang Y, Zhao Q, Li P, Wu B
RSC advances 2019 Aug 19;9(45):26238-26247
RSC advances 2019 Aug 19;9(45):26238-26247
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology 2017 Mar 6;216(3):675-693
The Journal of cell biology 2017 Mar 6;216(3):675-693
Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors.
Guenzel AJ, Collard R, Kraus JP, Matern D, Barry MA
Human gene therapy 2015 Mar;26(3):153-60
Human gene therapy 2015 Mar;26(3):153-60
Effects of adeno-associated virus serotype and tissue-specific expression on circulating biomarkers of propionic acidemia.
Guenzel AJ, Hillestad ML, Matern D, Barry MA
Human gene therapy 2014 Sep;25(9):837-43
Human gene therapy 2014 Sep;25(9):837-43
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 21988-1-AP(PCCA antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PCCA antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PCCA. This antibody recognizes human, mouse antigen. The PCCA antibody has been validated for the following applications: ELISA, WB, IHC analysis.
