V3416

antibody from NSJ Bioreagents

Targeting: TYMP ECGF1, MNGIE

Provider product page for V3416

Western blot

Immunoprecipitation

Immunohistochemistry

Other assay

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Immunohistochemistry [1]
Other assay [1]

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Product number: V3416 - Provider product page
Provider: NSJ Bioreagents
Product name: Thymidine Phosphorylase Antibody / PD-ECGF
Antibody type: Monoclonal
Description: Purified
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: P-GF.44C
Vial size: 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
Concentration: 0.2 mg/ml
Storage: Store the Thymidine Phosphorylase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

TYMP protein structure - V3416 shown in red.

Submitted references Pulmonary Tumor Thrombotic Microangiopathy Caused by Urothelial Carcinoma Expressing Vascular Endothelial Growth Factor, Platelet-derived Growth Factor, and Osteopontin.

Wakabayashi Y, Iwaya M, Akita M, Takeuchi W, Yamazaki K, Iijima A
Internal medicine (Tokyo, Japan) 2016;55(6):651-6

Introducing Cytology-Based Theranostics in Oral Squamous Cell Carcinoma: A Pilot Program.

Patrikidou A, Valeri RM, Kitikidou K, Destouni C, Vahtsevanos K
Pathology oncology research : POR 2016 Apr;22(2):401-11

Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1.

Tertil M, Skrzypek K, Florczyk U, Weglarczyk K, Was H, Collet G, Guichard A, Gil T, Kuzdzal J, Jozkowicz A, Kieda C, Pichon C, Dulak J
PloS one 2014 May 12;9(5):e97070

Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P
Neurochemical research 2013 Sep;38(9):1838-49

Expression of thymidine phosphorylase and cyclooxygenase-2 in melanoma.

Minisini AM, Pascoletti G, Intersimone D, Poletto E, Driol P, Spizzo R, Scott CA, Puglisi F, Fasola G, Di Loreto C
Melanoma research 2013 Apr;23(2):96-101

Pulmonary tumor thrombotic microangiopathy showing aggressive course after transurethral resection of urinary bladder: an autopsy case report.

Hirano H, Ichibori H, Kizaki T, Matsumoto T, Ohka Z, Mori T, Okamoto M, Ogasawara D, Kamemura K, Yoshikawa R, Itagaki T, Matsuda Y, Sano H
Medical molecular morphology 2012 Dec;45(4):238-42

Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior.

de Faria PR, Lima RA, Dias FL, de Faria PA, Eisenberg AL, do Nascimento Souza KC, Cardoso SV, Loyola AM
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2011 Jul;40(6):456-9

A phase II study of combination chemotherapy with capecitabine and cisplatin in patients with metastatic or recurrent squamous cell carcinoma of the head and neck.

Won YW, Park YH, Ahn MJ, Do IG, Ko YH, Park K
Annals of oncology : official journal of the European Society for Medical Oncology 2011 Feb;22(2):417-23

Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines.

Puppin C, Puglisi F, Pandolfi M, Di Loreto C, Damante G
Oncology reports 2011 Aug;26(2):309-14

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.

Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y, Lewis CE
Cancer research 2010 Jul 1;70(13):5270-80

Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blotting.

Nirmalan NJ, Harnden P, Selby PJ, Banks RE
The Journal of pathology 2009 Mar;217(4):497-506

Platelet-derived growth factor expression correlates with tumor grade and proliferative activity in human oligodendrogliomas.

Majumdar K, Radotra BD, Vasishta RK, Pathak A
Surgical neurology 2009 Jul;72(1):54-60

Decreased expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in basal cell carcinomas.

Stoebner PE, Le Gallic L, Berthe ML, Boulle N, Lallemant B, Marque M, Gaspard C, Delfour C, Lavabre-Bertrand T, Martinez J, Meunier L
Experimental dermatology 2008 Nov;17(11):908-15

The cytosol activity of thymidine phosphorylase in endometrial cancer.

Miszczak-Zaborska E, Kubiak R, Bieńkiewicz A, Bartkowiak J
Journal of experimental & clinical cancer research : CR 2008 Nov 5;27:64

Thymidine phoshorylase expression in breast cancer: the prognostic significance and its association with other angiogenesis related proteins and extracellular matrix components.

Ioachim E
Histology and histopathology 2008 Feb;23(2):187-96

Neoadjuvant treatment of colorectal cancer with bevacizumab: the perioperative angiogenic balance is sensitive to systemic thrombospondin-1 levels.

Brostjan C, Gebhardt K, Gruenberger B, Steinrueck V, Zommer H, Freudenthaler H, Roka S, Gruenberger T
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Apr 1;14(7):2065-74

Angiogenic factor expression in hepatic cirrhosis.

Giatromanolaki A, Kotsiou S, Koukourakis MI, Sivridis E
Mediators of inflammation 2007;2007:67187

Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients.

Bidgoli SA, Azizi E, Zavarhei MD
Pakistan journal of biological sciences : PJBS 2007 Oct 1;10(19):3350-5

A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients.

Ranieri G, Grammatica L, Patruno R, Zito AF, Valerio P, Iacobellis S, Gadaleta C, Gasparini G, Ribatti D
Journal of cellular and molecular medicine 2007 Mar-Apr;11(2):362-8

Angiogenesis in gastric cancer: importance of the thymidine phosphorylase expression of cancer cells as an angiogenic factor.

Han HS, Hwang TS
Oncology reports 2007 Jan;17(1):61-5

Immunohistochemical localization of thymidine phosphorylase in gastric cancer: is there a role of the differential expression in tumor cells and associated stromal cells?

Liakakos T, Troupis T, Ghiconti I, Triantafyllidis S, Macheras A, Karatzas G, Pavlakis K
Anticancer research 2006 Sep-Oct;26(5B):3899-903

H pylori status and angiogenesis factors in human gastric carcinoma.

Mangia A, Chiriatti A, Ranieri G, Abbate I, Coviello M, Simone G, Zito FA, Montemurro S, Rucci A, Di Leo A, Tommasi S, Berloco P, Xu JM, Paradiso A
World journal of gastroenterology 2006 Sep 14;12(34):5465-72

Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas.

Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Koukourakis MI
Journal of surgical oncology 2006 Sep 1;94(3):242-7

Micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PdEGF) in classical Hodgkin lymphoma (HL).

Mainou-Fowler T, Angus B, Miller S, Proctor SJ, Taylor PR, Wood KM
Leukemia & lymphoma 2006 Feb;47(2):223-30

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Supportive validation

Submitted by: NSJ Bioreagents (provider)
Main image
Experimental details: IHC testing of FFPE human placenta with Thymidine Phosphorylase antibody (clone P-GF.44C). Required HIER: requires boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.

Supportive validation

Submitted by: NSJ Bioreagents (provider)
Main image
Experimental details: SDS-PAGE Analysis of Purified, BSA-Free Thymidine Phosphorylase Antibody (clone P-GF.44C). Confirmation of Integrity and Purity of the Antibody.