12348-1-AP

antibody from Proteintech Group

Targeting: FABP5 E-FABP, KFABP, PA-FABP

Provider product page for 12348-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [59]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12348-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12348-1-AP, RRID:AB_2100341
Product name: FABP5 antibody
Antibody type: Polyclonal
Description: KD/KO validated FABP5 antibody (Cat. #12348-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FABP5 protein structure - 12348-1-AP shown in red.

Submitted references p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.

Tong J, Han T, Deng J, Gan Y, Ruan R, Zhao W, Xiong C, Liao Q, Chen S, Bu H, Xiong J, Zhou X, Hao Q
Redox biology 2026 Mar;90:104043

Imperatorin ameliorates metabolic dysfunction-associated fatty liver disease through modulating Suv39h1/Fabps/Cept1 signalling pathway.

Sun Y, Wang C, Wang Y, Hao R, Liu L, Jin Y, Sun H
British journal of pharmacology 2026 Mar;183(5):1104-1121

Fabp5 Is the Key Regulator Mediating γ-CEHC Differentiation in Osteoblasts and Osteoclasts.

Cheng C, Chen R, Li M, Lu S, Li X, Cui G, Chen H, Jiang X
BioFactors (Oxford, England) 2026 Jan-Feb;52(1):e70079

FOXC1 Regulates Cytokine Signaling, Inflammatory Pathways, and Retinoid Metabolism to Maintain Limbal Epithelial Cell Homeostasis In Vitro.

Kundu S, Amini M, Stachon T, Fries FN, Seitz B, Li Z, Li S, Liu S, Hsu SL, Suiwal S, Szentmáry N
International journal of molecular sciences 2026 Feb 15;27(4)

FABP5 Inhibitor Attenuates HPV11 Pseudovirion Infection by Reducing Lipid Droplet Formation.

Wang J, Chen S, Zhou C, Zhang J, Feng C, Zhu J, Zhang B, Wei Y, Hua C, Cheng H
ACS infectious diseases 2026 Apr 10;12(4):1362-1371

Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.

Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(6):e0326967

Identification and validation of icaritin-associated prognostic genes in hepatocellular carcinoma through network pharmacology, bioinformatics analysis, and cellular experiments.

Shi Y, Bai Y, Wu J, Yu Y, Yang X, Yang H, Jian W, Qing J
Frontiers in immunology 2025;16:1693028

Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.

Li D, Duan H, Jiang Z, Zhou C, Cao C, Ni M, He L, Zhu X, Jin L, Liu W, Gu L, Li H, Liu D, Zhao X, Zhao G, Li J
Free radical biology & medicine 2025 Sep;237:270-284

Disease-specific tau polymorphs define unique protein interaction networks across proteinopathies.

Puangmalai N, Bhatt N, Suthprasertporn N, Miranda-Morales EG, Shchankin N, Samples M, Balci AE, Liew JY, Montalbano M, Zhao Y, Kayed R
bioRxiv : the preprint server for biology 2025 Sep 15;

Proteomics-Based Mapping of the Lymph Node Metastasis Landscape in Cervical Cancer.

Hao Y, Liu Q, Wang B, Zhang W, Jiao X, Zhang T, Cui B
Journal of proteome research 2025 Oct 3;24(10):5226-5241

Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation.

Wu R, Zeng Y, Han J, Li L, Xiong QM, Li S, Fu S, Qin P, Wang Z, He Y, Yan Z, Xiao W, Zeng Z, Lian ZX, Zhao ZB, Xiao W, Jiang Y, Gong S
Cell reports 2025 Nov 25;44(11):116497

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.

Aisenberg WH, O'Brien CA, Sangster M, Yaqoob F, Zhang Y, Temsamrit B, Thom S, Gosse L, Chaluvadi S, Elfayomi B, Lee G, Polam V, Levitt EM, Liu G, Lombroso SI, Nemec KM, Clowry G, Nieves C, Rawat P, Church E, Martinez D, Shoffler C, Kancheva D, Petucci C, Taylor D, Kofler J, Erskine D, Movahedi K, Bennett ML, Bennett FC
Immunity 2025 May 13;58(5):1254-1268.e9

Melatonin treatment increases skin microbiota-derived propionic acid to alleviate atopic dermatitis.

Yang L, Wang P, Gao T, Huang X, Lin Z, Sweren E, Li Y, Chen L, Alphonse MP, Zhang J, Wang G
The Journal of allergy and clinical immunology 2025 Mar;155(3):880-891.e9

Asprosin-FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development.

Yu YY, Feng M, Chen Y, Jia HL, Zhang Q, Tong M, Li YX, Zhao Y, Liu XX, Cao SF, Wang ZK, Li HW, Liu X, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415846

Prion-induced ferroptosis is facilitated by RAC3.

Peng H, Pfeiffer S, Varynskyi B, Qiu M, Srinark C, Jin X, Zhang X, Williams K, Groveman BR, Foliaki ST, Race B, Thomas T, Chen C, Müller C, Kovács K, Arzberger T, Momma S, Haigh CL, Schick JA
Nature communications 2025 Jun 25;16(1):5385

Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut-liver axis.

Zhang X, Lau HC, Ha S, Liu C, Liang C, Lee HW, Ng QW, Zhao Y, Ji F, Zhou Y, Pan Y, Song Y, Zhang Y, Lo JCY, Cheung AHK, Wu J, Li X, Xu H, Wong CC, Wong VW, Yu J
Nature metabolism 2025 Jan;7(1):102-119

Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats.

Yi S, Mai T, Fang Y, Tian Q, Zhao S
Journal of biochemical and molecular toxicology 2025 Jan;39(1):e70101

Syncytin-1 deficiency impairs placental nutrient transport via PI3K/Akt/mTOR signaling.

Chen XL, Gong XX, Xiong ZL, Zhou D, Yang J, Zhang HF, Xue YS, Wang YN, Chen HB
The Journal of nutritional biochemistry 2025 Dec;146:110060

Residual tumor cells after insufficient radiofrequency ablation promote lung metastasis by educating CD177(hi)PAD4(hi) neutrophils.

Huang N, Fang Y, Zheng S, Wu J, Huang G, Deng X, Guan Y, Liang B, Zeng D, Xu B, Huang Y, Rong X, Wang C, Bin J, Liao Y, Wu Z, Shi M, Liao W
Nature communications 2025 Dec 2;17(1):208

Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro.

Li Z, Szentmáry N, Fries FN, Suiwal S, Chai N, Seitz B, Shi L, Amini M, Stachon T
Ophthalmology and therapy 2024 Nov;13(11):2931-2950

Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis.

Guo D, Zhang M, Qi B, Peng T, Liu M, Li Z, Fu F, Guo Y, Li C, Wang Y, Hu L, Li Y
Cell death and differentiation 2024 Mar;31(3):292-308

Helicobacter pylori infection exacerbates metabolic dysfunction-associated steatotic liver disease through lipid metabolic pathways: a transcriptomic study.

Chen X, Peng R, Peng D, Liu D, Li R
Journal of translational medicine 2024 Jul 29;22(1):701

Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.

Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655

High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome.

Liu J, Li J, Wu X, Zhang M, Yan G, Sun H, Li D
Journal of ovarian research 2024 Feb 19;17(1):44

Stigmasterol exerts antiglioma effects by regulating lipid metabolism.

Wei T, Li R, Guo S, Liang C
Molecular medicine reports 2024 Dec;30(6)

Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway.

Chen NN, Ma XD, Miao Z, Zhang XM, Han BY, Almaamari AA, Huang JM, Chen XY, Liu YJ, Su SW
Frontiers in pharmacology 2023;14:1150861

Fabp5 is a common gene between a high-cholesterol diet and acute pancreatitis.

Qiu M, Cai F, Huang Y, Sun L, Li J, Wang W, Basharat Z, Zippi M, Goyal H, Pan J, Hong W
Frontiers in nutrition 2023;10:1284985

A transient wave of Bhlhe41(+) resident macrophages enables remodeling of the developing infarcted myocardium.

Xu Y, Jiang K, Su F, Deng R, Cheng Z, Wang D, Yu Y, Xiang Y
Cell reports 2023 Oct 31;42(10):113174

L-theanine regulates the immune function of SD rats fed high-protein diets through the FABP5/IL-6/STAT3/PPARα pathway.

Zhang Y, Song Y, Zhang J, Li L, He L, Bo J, Gong Z, Xiao W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114095

L-Theanine Mitigates the Harmful Effects of Excess High-Protein Diet in Rats by Regulating Protein Metabolism.

Lin L, Zhang J, He L, Li L, Song Y, Xiao W, Gong Z
Molecular nutrition & food research 2023 Jan;67(2):e2200198

IGF2 May Enhance Placental Fatty Acid Metabolism by Regulating Expression of Fatty Acid Carriers in the Growth of Fetus and Placenta during Late Pregnancy in Pigs.

Wu Z, Hu G, Zhang Y, Ao Z
Genes 2023 Apr 5;14(4)

Effects of Fatty Acids on Proliferation of Cultured Wild-type and FABP5-KO Thymic Epithelial Cells.

Adachi Y
Journal of UOEH 2022;44(3):239-248

Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway.

Lei Q, Yu Z, Li H, Cheng J, Wang Y
Journal of advanced research 2022 Sep;40:197-206

Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.

He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S
iScience 2022 Nov 18;25(11):105214

Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response element binding protein.

Tang Y, Li K, Hu B, Cai Z, Li J, Tao H, Cao J
Cancer biology & therapy 2022 Dec 31;23(1):424-438

Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.

He H, Chen C, Zhao W
International journal of biological macromolecules 2022 Dec 1;222(Pt B):3057-3065

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis.

Pavel P, Leman G, Hermann M, Ploner C, Eichmann TO, Minzaghi D, Radner FPW, Del Frari B, Gruber R, Dubrac S
JID innovations : skin science from molecules to population health 2021 Sep;1(3):100033

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C, Chen S
Biomaterials 2021 Nov;278:121183

Heparin-Binding Protein 17/Fibroblast Growth Factor-Binding Protein-1 Knockout Inhibits Proliferation and Induces Differentiation of Squamous Cell Carcinoma Cells.

Shintani T, Higaki M, Okamoto T
Cancers 2021 May 29;13(11)

Differentially expressed proteins identified by TMT proteomics analysis in children with verrucous epidermal naevi.

Yuan T, Cai ML, Sheng YM, Ding X, Shen TT, Li WR, Huang H, Liang B, Zhang XJ, Zhu QX
Journal of the European Academy of Dermatology and Venereology : JEADV 2021 Jun;35(6):1393-1406

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Guo Y, Liu Y, Zhao S, Xu W, Li Y, Zhao P, Wang D, Cheng H, Ke Y, Zhang X
Nature communications 2021 Dec 7;12(1):7094

Proteome characteristics of liver tissue from patients with parenteral nutrition-associated liver disease.

Maitiabola G, Tian F, Sun H, Zhang L, Gao X, Xue B, Wang X
Nutrition & metabolism 2020;17:43

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.

Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672

Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer.

Apaya MK, Hsiao PW, Yang YC, Shyur LF
Cancers 2020 Jan 13;12(1)

Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115

Wu G, Xu Y, Wang Q, Li J, Li L, Han C, Xia Q
European journal of pharmacology 2019 Nov 5;862:172637

Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.

Li X, Li P, Wang L, Zhang M, Gao X
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7005-7015

Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.

Melville D, Gorur A, Schekman R
Molecular biology of the cell 2019 Feb 1;30(3):387-399

Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells.

Li YT, Tian XT, Wu ML, Zheng X, Kong QY, Cheng XX, Zhu GW, Liu J, Li H
International journal of molecular sciences 2018 Mar 29;19(4)

The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death.

Liu G, Wang K, Kuang S, Cao R, Bao L, Liu R, Liu H, Sun C
Cell death & disease 2018 Jun 7;9(6):689

Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity.

Zhang S, Liu H, Li H, Wu M, Yu Y, Li F, Cheng X
RSC advances 2018 Apr 11;8(25):14048-14055

Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.

Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodriquez MI, Longley BJ, Wood GS, Mukhtar H
Antioxidants & redox signaling 2017 Jan 10;26(2):49-69

Differential Proteomic Analysis of Gender-dependent Hepatic Tumorigenesis in Hras12V Transgenic Mice.

Rong Z, Fan T, Li H, Li J, Wang K, Wang X, Dong J, Chen J, Wang F, Wang J, Wang A
Molecular & cellular proteomics : MCP 2017 Aug;16(8):1475-1490

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.

Xia SL, Wu ML, Li H, Wang JH, Chen NN, Chen XY, Kong QY, Sun Z, Liu J
Oncotarget 2015 Mar 20;6(8):5889-902

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

Gericke J, Ittensohn J, Mihály J, Dubrac S, Rühl R
PloS one 2013;8(8):e71244

E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro.

Dallaglio K, Marconi A, Truzzi F, Lotti R, Palazzo E, Petrachi T, Saltari A, Coppini M, Pincelli C
Experimental dermatology 2013 Apr;22(4):255-61

CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.

Chen NN, Li Y, Wu ML, Liu ZL, Fu YS, Kong QY, Chen XY, Li H, Liu J
Experimental dermatology 2012 Jan;21(1):13-8

Identification of potential therapeutic targets in human head & neck squamous cell carcinoma.

Han J, Kioi M, Chu WS, Kasperbauer JL, Strome SE, Puri RK
Head & neck oncology 2009 Jul 14;1:27

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 12348-1-AP(FABP5 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FABP5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FABP5. This antibody recognizes human,mouse,rat antigen. The FABP5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12348-1-AP.pdf

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