17240-1-AP

antibody from Proteintech Group

Targeting: NSUN6 ARL5B-AS1, FLJ23743, NOPD1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

17240-1-AP

Provider

Proteintech Group

Product name

NSUN6 antibody

Antibody type

Polyclonal

Description

KD/KO validated NSUN6 antibody (Cat. #17240-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Integrated machine learning-based RNA sequencing and single-cell analysis reveal RNA methylation regulation patterns in the immune microenvironment of Alzheimer's disease.

Wu S, Guo T, Zheng X, Gu C, Hu Y, Gu X, Zhou X
Neural regeneration research 2026 Aug 1;21(8):3754-3768

---

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging.

Zhou J, Han Y, Ji F, Zhang R, Liang Y, Zhao X, Hou R
Frontiers in genetics 2025;16:1477542

---

Inhibition of NSUN6 protects against intermittent hypoxia-induced oxidative stress and inflammatory response in adipose tissue through suppressing macrophage ferroptosis and M1 polarization.

Wang X, Gong L, Wei C, Zhao Y, Ran L, Li P, Gu W, Wu X, Liang Z, Wang X
Life sciences 2025 Mar 1;364:123433

---

Construction of a Prognostic Model Using RNA Processing Factor Genes and the Key Role of NSUN6 in Glioma Outcomes.

Chen J, Ying C, Gu Z, Zhu B, Wang J, Qian Y, Zheng H, Zhang J, Wang Y
Journal of cellular and molecular medicine 2025 Jun;29(12):e70668

---

MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma.

He M, Li T, Wang A, Liu Y, Wang X, Liu Z, Xie J, Wang Y, Wang Y, Ren Z, Ge S, Yang L, Yuan Y
Cell death and differentiation 2025 Dec;32(12):2412-2426

---

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing.

Zhou J, Zhao D, Li J, Kong D, Li X, Zhang R, Liang Y, Gao X, Qian Y, Wang D, Chen J, Lai L, Han Y, Li Z
eLife 2025 Apr 8;13

---

STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m(5)C methylation of Gpx4 mRNA.

Zhang X, Zhang Y, Li R, Li Y, Wang Q, Wang Y, Chen X, Wang W, Pang E, Li Y, Wang J, Zheng J, Zhang J
Cell reports 2024 Nov 26;43(11):114885

---

RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma.

Han H, Sun Y, Wei W, Huang Z, Cheng M, Qiu H, Wang J, Zheng S, Liu L, Zhang Q, Zhang C, Ma J, Guo S, Wang Z, Li Z, Jiang X, Lin S, Liu Q, Zhang S
iScience 2024 Mar 15;27(3):109327

---

Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

---

NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer.

Yu M, Ni M, Xu F, Liu C, Chen L, Li J, Xia S, Diao Y, Chen J, Zhu J, Wu X, Tang M, Li J, Ke G
Molecular cancer 2024 Jul 5;23(1):139

---

Base-resolution m(5)C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach.

Lu L, Zhang X, Zhou Y, Shi Z, Xie X, Zhang X, Gao L, Fu A, Liu C, He B, Xiong X, Yin Y, Wang Q, Yi C, Li X
Molecular cell 2024 Aug 8;84(15):2984-3000.e8

---

ALYREF promotes the metastasis of nasopharyngeal carcinoma by increasing the stability of NOTCH1 mRNA.

Jin Y, Yao J, Fu J, Huang Q, Luo Y, You Y, Zhang W, Zhong Q, Xia T, Xia L
Cell death & disease 2024 Aug 8;15(8):578

---

Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.

Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457

---

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming.

Yan D, Xie Y, Huang L, Zhang Y, Gu R, Xie H, Huang X, Luo H
Journal of cellular and molecular medicine 2023 Aug;27(16):2398-2411

---

Targeted Quantitative Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Using Stable Isotope-Labeled Peptides.

Qi TF, Liu X, Tang F, Yin J, Yu K, Wang Y
Analytical chemistry 2022 Sep 20;94(37):12559-12564

---

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6.

Selmi T, Hussain S, Dietmann S, Heiß M, Borland K, Flad S, Carter JM, Dennison R, Huang YL, Kellner S, Bornelöv S, Frye M
Nucleic acids research 2021 Jan 25;49(2):1006-1022

---

CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators.

Fang L, Wang W, Li G, Zhang L, Li J, Gan D, Yang J, Tang Y, Ding Z, Zhang M, Zhang W, Deng D, Song Z, Zhu Q, Cui H, Hu Y, Chen W
Molecular systems biology 2020 Nov;16(11):e10025

---

Genome-wide identification of mRNA 5-methylcytosine in mammals.

Huang T, Chen W, Liu J, Gu N, Zhang R
Nature structural & molecular biology 2019 May;26(5):380-388

---

Cytosine-5 RNA methylation links protein synthesis to cell metabolism.

Gkatza NA, Castro C, Harvey RF, Heiß M, Popis MC, Blanco S, Bornelöv S, Sajini AA, Gleeson JG, Griffin JL, West JA, Kellner S, Willis AE, Dietmann S, Frye M
PLoS biology 2019 Jun;17(6):e3000297