PA5-38005

antibody from Invitrogen Antibodies

Targeting: CDO1

Western blot (Data presented on provider website)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

PA5-38005

Provider

Invitrogen Antibodies

Product name

CDO1 Polyclonal Antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

A recommended positive control is rat liver tissue lysate.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100 µg

Concentration

1 mg/mL

Storage

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

References

Submitted references

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.

Xu Q, Li Y, Gao X, Kang K, Williams JG, Tong L, Liu J, Ji M, Deterding LJ, Tong X, Locasale JW, Li L, Shats I, Li X
Nature communications 2020 Aug 7;11(1):3978

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Fig. 1 Key SAA metabolic enzymes and HNF4alpha are correlated in liver cancers. a SAA metabolic pathways. MAT1A methionine adenosyltransferase 1A, MAT2A methionine adenosyltransferase 2A, MAT2B methionine adenosyltransferase 2B, GNMT glycine N-methyltransferase, SAHH adenosylhomocysteinase, BHMT betaine-homocysteine S-methyltransferase, CBS cystathionine beta-synthase, CTH/CSE cystathionine gamma-lyase, CDO1 cysteine dioxygenase type 1, CSAD cysteine sulfinic acid decarboxylase. Key SAA enzymes investigated in this study are highlighted in orange. b HNF4alpha is clustered together with key SAA metabolic enzymes in liver cancer patients. The mRNA levels of HNF4alpha-regulated liver functional genes (Red), mesenchymal markers (Blue), and key SAA metabolic enzymes (Orange) from 373 liver cancer patients from the TCGA LIHC dataset were clustered and represented by the heatmap as described in Methods. c Expression of key SAA metabolic enzymes is positively correlated with HNF4alpha expression in liver cancer patients ( n = 371). The pair-wise Pearson correlation coefficient and the corresponding p -value between two genes were calculated using MATLAB. Two outlier samples in which HNF4alpha expression levels were more than 3 interquartile ranges (IQRs) below the first quartile among the 373 samples were removed. d Expression of key SAA metabolic enzymes is negatively correlated with TWIST1 expression in liver cancer patients ( n = 373). e HNF4alpha is clustered together with key SA