Antibody data
- Antibody Data
- Antigen structure
- References [32]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- HPA012657 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA012657, RRID:AB_2299684
- Product name
- Anti-PLA2R1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human PLA2R1, Gene description: phospholipase A2 receptor 1, 180kDa, Alternative Gene Names: CLEC13C, PLA2-R, PLA2G1R, PLA2IR, Validated applications: WB, IHC, Uniprot ID: Q13018, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.2 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Target Antigens of Membranous Nephropathy With Syphilis Infection
Clinicopathologic Features of Antibrush Border Antibody Disease
Combined evaluation of glomerular phospholipase A2 receptor and immunoglobulin G subclass in membranous nephropathy
Measurement of urinary exosomal phospholipase A2 receptor is a sensitive method for diagnosis of PLA2R-associated membranous nephropathy
Segmental Membranous Glomerulopathy in Adults
Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy
C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy
Single-Nephron GFR in Different Glomerular Basement Membrane Stages of Membranous Nephropathy
Complete remission of primary membranous nephropathy following hepatitis E infection
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan
NELL1 is a target antigen in malignancy-associated membranous nephropathy
Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec’s Reference Center
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
Recurrent membranous nephropathy with a possible alteration in the etiology: a case report
Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis
Membranous nephropathy in patients with HIV: a report of 11 cases
Renal Manifestations of Common Variable Immunodeficiency
Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy
Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study
The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action
Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy
PLA2R1 kills cancer cells by inducing mitochondrial stress
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy
Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy
PLA2R Autoantibodies and PLA2R Glomerular Deposits in Membranous Nephropathy
Autoantibodies Specific for the Phospholipase A2 Receptor in Recurrent and De Novo Membranous Nephropathy
Zhang L, Zhang M, Xie Q, Wang Y, Ni Z, Liu S, Zhou W
Kidney International Reports 2024;9(2):401-409
Kidney International Reports 2024;9(2):401-409
Clinicopathologic Features of Antibrush Border Antibody Disease
Murphy J, Caza T, Cassol C, Storey A, Ambruzs J, Boils C, Walker P, Sharma S, Messias N, Hennigar R, Andeen N, VanBeek C, Palmer M, Sankar L, Sanghi P, Dinesh K, Dicker L, Urisman A, Larsen C
Kidney International Reports 2024;9(2):370-382
Kidney International Reports 2024;9(2):370-382
Combined evaluation of glomerular phospholipase A2 receptor and immunoglobulin G subclass in membranous nephropathy
Ueki K, Tsuchimoto A, Matsukuma Y, Ataka E, Okamoto H, Tanaka S, Masutani K, Kitazono T, Nakano T
Clinical Kidney Journal 2024;17(6)
Clinical Kidney Journal 2024;17(6)
Measurement of urinary exosomal phospholipase A2 receptor is a sensitive method for diagnosis of PLA2R-associated membranous nephropathy
Wang B, Fu Y, Xie L, Cao J, Yang M, Li M, Chen T, Zhang X, Luo Q, Lv L, Liu B
Clinical Kidney Journal 2024;17(1)
Clinical Kidney Journal 2024;17(1)
Segmental Membranous Glomerulopathy in Adults
Zhu S, Liu X, Yue S, Luo B, Song Z, Xu X, Wang L, Hou X, Li K, Liang Q, Zhou Z, Chen W, Zheng L
Kidney Diseases 2023;9(6):507-516
Kidney Diseases 2023;9(6):507-516
Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy
Kouri A, Caza T, Beck L, Misurac J, Evans M, Phillips C, Eadon M, Larsen C, Andreoli S, Bu L, Rheault M, Khalid M
Kidney International Reports 2023;8(11):2368-2375
Kidney International Reports 2023;8(11):2368-2375
C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy
Teisseyre M, Beyze A, Perrochia H, Szwarc I, Bourgeois A, Champion C, Chenine L, Serre J, Broner J, Aglae C, Pernin V, Le Quintrec M
Kidney International Reports 2023;8(1):103-114
Kidney International Reports 2023;8(1):103-114
Single-Nephron GFR in Different Glomerular Basement Membrane Stages of Membranous Nephropathy
Okabayashi Y, Tsuboi N, Marumoto H, Sasaki T, Haruhara K, Kanzaki G, Koike K, Ueda H, Shimizu A, Puelles V, D'Agati V, Yokoo T
Kidney360 2023;4(6):e777-e786
Kidney360 2023;4(6):e777-e786
Complete remission of primary membranous nephropathy following hepatitis E infection
Takanohashi S, Sugiura T, Koyano A, Ueno T, Rachi H, Shiratori K, Shimasaki M, Igarashi H, Kitayama Y, Togawa A
CEN Case Reports 2023;12(4):384-389
CEN Case Reports 2023;12(4):384-389
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
Caza T, Storey A, Hassen S, Herzog C, Edmondson R, Arthur J, Kenan D, Larsen C
Kidney International 2023;103(3):593-606
Kidney International 2023;103(3):593-606
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Li Y, Yu J, Wang M, Cui Z, Zhao M
Renal Failure 2022;44(1):304-313
Renal Failure 2022;44(1):304-313
Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan
Iwakura T, Ema C, Isobe S, Fujikura T, Ohashi N, Kato A, Yasuda H
Scientific Reports 2022;12(1)
Scientific Reports 2022;12(1)
NELL1 is a target antigen in malignancy-associated membranous nephropathy
Caza T, Hassen S, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey L, Sharma S, Kenan D, Larsen C
Kidney International 2021;99(4):967-976
Kidney International 2021;99(4):967-976
Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec’s Reference Center
Leclerc S, Benkirane K, Nadeau-Fredette A, Elftouh N, Lafrance J, Pichette V, Royal V, Lamarche C, Laurin L
Canadian Journal of Kidney Health and Disease 2021;8
Canadian Journal of Kidney Health and Disease 2021;8
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
Al-Rabadi L, Caza T, Trivin-Avillach C, Rodan A, Andeen N, Hayashi N, Williams B, Revelo M, Clayton F, Abraham J, Lin E, Liou W, Zou C, Ramkumar N, Cummins T, Wilkey D, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck L
Journal of the American Society of Nephrology 2021;32(7):1666-1681
Journal of the American Society of Nephrology 2021;32(7):1666-1681
Recurrent membranous nephropathy with a possible alteration in the etiology: a case report
Matsumoto A, Matsui I, Mano K, Mizuno H, Katsuma Y, Yasuda S, Shimada K, Inoue K, Oki T, Hanai T, Kojima K, Kaneko T, Isaka Y
BMC Nephrology 2021;22(1)
BMC Nephrology 2021;22(1)
Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
Caza T, Hassen S, Kenan D, Storey A, Arthur J, Herzog C, Edmondson R, Bourne T, Beck L, Larsen C
Kidney360 2021;2(8):1275-1286
Kidney360 2021;2(8):1275-1286
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis
Caza T, Hassen S, Kuperman M, Sharma S, Dvanajscak Z, Arthur J, Edmondson R, Storey A, Herzog C, Kenan D, Larsen C
Kidney International 2021;100(1):171-181
Kidney International 2021;100(1):171-181
Membranous nephropathy in patients with HIV: a report of 11 cases
Charu V, Andeen N, Walavalkar V, Lapasia J, Kim J, Lin A, Sibley R, Higgins J, Troxell M, Kambham N
BMC Nephrology 2020;21(1)
BMC Nephrology 2020;21(1)
Renal Manifestations of Common Variable Immunodeficiency
Caza T, Hassen S, Larsen C
Kidney360 2020;1(6):491-500
Kidney360 2020;1(6):491-500
Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy
Zhang Q, Huang B, Liu X, Liu B, Zhang Y, Zhang Z, Hua J, Fan Y, Hu L, Meng M, Wu M, Wang L, Hu Z, Sun Z
Scientific Reports 2017;7(1)
Scientific Reports 2017;7(1)
Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study
Wang J, Xie Q, Sun Z, Xu N, Li Y, Wang L, Liu S, Xue J, Hao C
BMC Nephrology 2017;18(1)
BMC Nephrology 2017;18(1)
The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action
Griveau A, Devailly G, Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker J, Vindrieux D, Bernard D
Oncogene 2016;35(38):5033-5042
Oncogene 2016;35(38):5033-5042
Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease
Dauvergne M, Moktefi A, Rabant M, Vigneau C, Kofman T, Burtey S, Corpechot C, Stehlé T, Desvaux D, Rioux-Leclercq N, Rouvier P, Knebelmann B, Boffa J, Frouget T, Daugas E, Jablonski M, Dahan K, Brocheriou I, Remy P, Grimbert P, Lang P, Chazouilleres O, Sahali D, Audard V
Medicine 2015;94(30):e1243
Medicine 2015;94(30):e1243
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
Remuzzi G, Iwakura T, Ohashi N, Kato A, Baba S, Yasuda H
PLOS ONE 2015;10(9):e0138841
PLOS ONE 2015;10(9):e0138841
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
Iwakura T, Ohashi N, Kato A, Baba S, Yasuda H, Remuzzi G
PLOS ONE 2015 September;10(9)
PLOS ONE 2015 September;10(9)
Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy
Akiyama S, Akiyama M, Imai E, Ozaki T, Matsuo S, Maruyama S
Clinical and Experimental Nephrology 2014;19(4):653-660
Clinical and Experimental Nephrology 2014;19(4):653-660
PLA2R1 kills cancer cells by inducing mitochondrial stress
Augert A, Vindrieux D, Girard C, Le Calvé B, Gras B, Ferrand M, Bouchet B, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D
Free Radical Biology and Medicine 2013;65
Free Radical Biology and Medicine 2013;65
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy
Svobodova B, Honsova E, Ronco P, Tesar V, Debiec H
Nephrology Dialysis Transplantation 2013;28(7):1839-1844
Nephrology Dialysis Transplantation 2013;28(7):1839-1844
Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy
Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen U, Stahl R
Kidney International 2012;82(7):797-804
Kidney International 2012;82(7):797-804
PLA2R Autoantibodies and PLA2R Glomerular Deposits in Membranous Nephropathy
Debiec H, Ronco P
New England Journal of Medicine 2011;364(7):689-690
New England Journal of Medicine 2011;364(7):689-690
Autoantibodies Specific for the Phospholipase A2 Receptor in Recurrent and De Novo Membranous Nephropathy
Debiec H, Martin L, Jouanneau C, Dautin G, Mesnard L, Rondeau E, Mousson C, Ronco P
American Journal of Transplantation 2011;11(10):2144-2152
American Journal of Transplantation 2011;11(10):2144-2152
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Recombinant expression validation
- Main image
- Experimental details
- Western blot analysis in control (vector only transfected HEK293T lysate) and PLA2R1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY423477).
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human kidney and pancreas tissues using HPA012657 antibody. Corresponding PLA2R1 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol